Search Results - "Lidereau, R."

A refined molecular taxonomy of breast cancer by Guedj, M, Marisa, L, de Reynies, A, Orsetti, B, Schiappa, R, Bibeau, F, MacGrogan, G, Lerebours, F, Finetti, P, Longy, M, Bertheau, P, Bertrand, F, Bonnet, F, Martin, A L, Feugeas, J P, Bièche, I, Lehmann-Che, J, Lidereau, R, Birnbaum, D, Bertucci, F, de Thé, H, Theillet, C

“…The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression…”
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Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach by Tozlu, S, Girault, I, Vacher, S, Vendrell, J, Andrieu, C, Spyratos, F, Cohen, P, Lidereau, R, Bieche, I

“…The estrogen receptor alpha (ERα) plays a critical role in the pathogenesis and clinical behavior of breast cancer. To obtain further insights into the…”
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ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels by Rondeau, S, Vacher, S, De Koning, L, Briaux, A, Schnitzler, A, Chemlali, W, Callens, C, Lidereau, R, Bièche, I

“…Background: Ataxia telangiectasia mutated (ATM) is a kinase that has a central role in the maintenance of genomic integrity by activating cell cycle…”
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Screening BRCA1 and BRCA2 unclassified variants for splicing mutations using reverse transcription PCR on patient RNA and an ex vivo assay based on a splicing reporter minigene by Bonnet, C, Krieger, S, Vezain, M, Rousselin, A, Tournier, I, Martins, A, Berthet, P, Chevrier, A, Dugast, C, Layet, V, Rossi, A, Lidereau, R, Frébourg, T, Hardouin, A, Tosi, M

“…Many unclassified variants (UV) of BRCA1 or BRCA2 may have an effect on pre-mRNA splicing. Patient blood samples suitable for RNA extraction are not always…”
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Hedgehog pathway activation in human transitional cell carcinoma of the bladder by Pignot, G, Vieillefond, A, Vacher, S, Zerbib, M, Debre, B, Lidereau, R, Amsellem-Ouazana, D, Bieche, I

“…Background: The Hedgehog (Hh) signalling pathway functions as an organiser in embryonic development. Recent studies have shown constitutive activation of this…”
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Inhibition of the Wnt β-catenin pathway by the WWOX tumor suppressor protein by Bouteille, N, Driouch, K, Hage, P El, Sin, S, Formstecher, E, Camonis, J, Lidereau, R, Lallemand, F

“…The WWOX gene encodes a candidate tumor suppressor protein (WWOX) implicated in a variety of human diseases such as cancer. To better understand the molecular…”
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CXC chemokines located in the 4q21 region are up-regulated in breast cancer by Bièche, Ivan, Chavey, Carine, Andrieu, Catherine, Busson, Muriel, Vacher, Sophie, Le Corre, Ludovic, Guinebretière, Jean-Marc, Burlinchon, Sandrine, Lidereau, Rosette, Lazennec, Gwendal

“…Recent data suggest that chemokines could be essential players in breast carcinogenesis. We previously showed that the CXC chemokine CXCL8 (interleukin-8) was…”
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Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells by BELLAHCENE, A, BACHELIER, R, DETRY, C, LIDEREAU, R, CLEZARDIN, P, CASTRONOVO, V

“…Metastatic breast cancer cells exhibit the selective ability to seed and grow in the skeleton. We and others have previously reported that human breast tumors…”
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Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases by Dziȩgiel, P, Owczarek, T, Plaz̀uk, E, Gomułkiewicz, A, Majchrzak, M, Podhorska-Okołów, M, Driouch, K, Lidereau, R, Ugorski, M

“…Background: It was shown recently on the level of gene expression that UGT8 , coding UDP-galactose:ceramide galactosyltransferase, is one of six genes whose…”
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Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests by Pujol, P., Lyonnet, D. Stoppa, Frebourg, T., Blin, J., Picot, M. C., Lasset, C., Dugast, C., Berthet, P., de Paillerets, B. Bressac, Sobol, H., Grandjouan, S., Soubrier, F., Buecher, B., Guimbaud, R., Lidereau, R., Jonveaux, P., Houdayer, C., Giraud, S., Olschwang, S., Nogue, E., Galibert, V., Bara, C., Nowak, F., Khayat, D., Nogues, C.

“…Based on nationwide data from the French national cancer institute (INCa), we analyzed the evolution of cancer genetics consultations and testing over time,…”
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Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP by Di Benedetto, M., Bièche, I., Deshayes, F., Vacher, S., Nouet, S., Collura, V., Seitz, I., Louis, S., Pineau, P., Amsellem-Ouazana, D., Couraud, P.O., Strosberg, A.D., Stoppa-Lyonnet, D., Lidereau, R., Nahmias, C.

“…The Mitochondrial Tumor suppressor 1 ( MTUS1) gene is a newly identified candidate tumor suppressor gene at chromosomal position 8p22. We report here that…”
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VEGF overexpression in clinically localized prostate tumors and neuropilin‐1 overexpression in metastatic forms by Latil, A., Bièche, I., Pesche, S., Valéri, A., Fournier, G., Cussenot, O., Lidereau, R.

“…Studies comparing tumor neovascularity with pathological findings suggest that angiogenesis contributes to the pathogenesis of prostate cancer. We have…”
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Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays by Bièche, I, Olivi, M, Noguès, C, Vidaud, M, Lidereau, R

“…The CCND1 gene, a key cell-cycle regulator, is often altered in breast cancer, but the mechanisms underlying CCND1 dysregulation and the clinical significance…”
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Rare germline large rearrangements in the BRCA1/2 genes and eight candidate genes in 472 patients with breast cancer predisposition by Rouleau, E., Jesson, B., Briaux, A., Nogues, C., Chabaud, V., Demange, L., Sokolowska, J., Coulet, F., Barouk-Simonet, E., Bignon, Y. J., Bonnet, F., Bourdon, V., Bronner, M., Caputo, S., Castera, L., Delnatte, C., Delvincourt, C., Fournier, J., Hardouin, A., Muller, D., Peyrat, J. P., Toulas, C., Uhrhammer, N., Vidal, V., Stoppa-Lyonnet, D., Bieche, I., Lidereau, R.

“…Hereditary breast cancers account for up to 5–10 % of breast cancers and a majority are related to the BRCA1 and BRCA2 genes. However, many families with…”
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First large rearrangement in the MUTYH gene and attenuated familial adenomatous polyposis syndrome by Rouleau, E, Zattara, H, Lefol, C, Noguchi, T, Briaux, A, Buecher, B, Bourdon, V, Sobol, H, Lidereau, R, Olschwang, S

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115 A Diagnostic Genetic Test for the Physical Mapping of Germline Rearrangements in the Susceptibility Breast Cancer Genes BRCA1 and BRCA2 by Ceppi, M, Cheeseman, K, Rouleau, E, Thomas, A, Briaux, A, Lefol, C, Walrafen, P, Bensimon, A, Conseiller, E, Lidereau, R

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Significant contribution of germline BRCA2 rearrangements in male breast cancer families by TOURNIER, Isabelle, BRESSAC-DE PAILLERETS, Brigitte, LORTHOLARY, Alain, CHAPPUIS, Pierre, BOURDON, Violaine, BONADONA, Valérie, MAUGARD, Christine, GILBERT, Brigitte, NOGUES, Catherine, FREBOURG, Thierry, TOSI, Mario, SOBOL, Hagay, STOPPA-LYONNET, Dominique, LIDEREAU, Rosette, BARROIS, Michel, MAZOYER, Sylvie, COULET, Florence, HARDOUIN, Agnès, CHOMPRET, Agnès

“…Although screening for large deletions or duplications of the BRCA1 gene is becoming a routine component of the molecular diagnosis of familial breast cancer,…”
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Molecular alterations in sporadic breast cancer by Lerebours, F., Lidereau, R.

“…Breast cancer is a genetic disease. Like other human cancers, it is thought to occur as the result of progressive accumulation of genetic aberrations. These…”
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KRAS mutation status in colorectal cancer to predict response to EGFR targeted therapies: the need for a more precise definition by Rouleau, E, Spyratos, F, Dieumegard, B, Guinebretière, J M, Lidereau, R, Bièche, I

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Oligonucleotide microarray analysis of estrogen receptor α-positive postmenopausal breast carcinomas: identification of HRPAP20 and TIMELESS as outstanding candidate markers to predict the response to tamoxifen by Tozlu-Kara, S, Roux, V, Andrieu, C, Vendrell, J, Vacher, S, Lazar, V, Spyratos, F, Tubiana-Hulin, M, Cohen, P, Dessen, P, Lidereau, R, Bièche, I

“…AbstractThe estrogen receptor α (ERα) status of breast tumors is used to identify patients who may respond to endocrine agents such as tamoxifen. However, ERα…”
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