Search Results - "Liddle, C."

Prospective data collection of off-label use of rituximab in Australian public hospitals by O'Connor, K., Liddle, C.

“…Background Rituximab is a chimeric, anti‐CD20 monoclonal antibody registered for the treatment of B‐cell malignancies and refractory rheumatoid arthritis in…”
Get full text

Histone Modifications in Papillomavirus Virion Minichromosomes by Porter, Samuel S, Liddle, Jennifer C, Browne, Kristen, Pastrana, Diana V, Garcia, Benjamin A, Buck, Christopher B, Weitzman, Matthew D, McBride, Alison A

“…An unusual feature of papillomaviruses is that their genomes are packaged into virions along with host histones. Viral minichromosomes were visualized as…”
Get full text

Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases by Booth, D R, Ding, N, Parnell, G P, Shahijanian, F, Coulter, S, Schibeci, S D, Atkins, A R, Stewart, G J, Evans, R M, Downes, M, Liddle, C

“…The vitamin D receptor (VDR) is a ligand-activated transcription factor that regulates gene expression in many cell types, including immune cells. It requires…”
Get full text

The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones by Liu, Wallace H, Roemer, Sarah C, Zhou, Yeyun, Shen, Zih-Jie, Dennehey, Briana K, Balsbaugh, Jeremy L, Liddle, Jennifer C, Nemkov, Travis, Ahn, Natalie G, Hansen, Kirk C, Tyler, Jessica K, Churchill, Mair Ea

“…The histone chaperone Chromatin Assembly Factor 1 (CAF-1) deposits tetrameric (H3/H4) histones onto newly-synthesized DNA during DNA replication. To understand…”
Get full text

A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B by El Sharkawy, R., Thabet, K., Lampertico, P., Petta, S., Mangia, A., Berg, T., Metwally, M., Bayoumi, A., Boonstra, A., Brouwer, W. P., Smedile, A., Abate, M. L., Loglio, A., Douglas, M. W., Khan, A., Santoro, R., Fischer, J., Leeming, D. J., Liddle, C., George, J., Eslam, M.

“…Summary Background Host genetic modifiers of the natural history of chronic hepatitis B (CHB) remain poorly understood. Recently, a genome‐wide association…”
Get full text

Inflammation and Altered Drug Clearance in Cancer: Transcriptional Repression of a Human CYP3A4 Transgene in Tumor-bearing Mice by Robertson, GR, Liddle, C, Clarke, SJ

“…A tumor‐associated inflammatory response has recently been found to contribute to the considerable interindividual variability in cytotoxic drug clearance seen…”
Get full text

The Okur-Chung Neurodevelopmental Syndrome Mutation CK2K198R Leads to a Rewiring of Kinase Specificity by Caefer, Danielle M., Phan, Nhat Q., Liddle, Jennifer C., Balsbaugh, Jeremy L., O’Shea, Joseph P., Tzingounis, Anastasios V., Schwartz, Daniel

“…Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of protein kinase CK2…”
Get full text

IFNL3/4 genotype is associated with altered immune cell populations in peripheral blood in chronic hepatitis C infection by O'Connor, K S, Read, S A, Wang, M, Schibeci, S, Eslam, M, Ong, A, Weltman, M D, Douglas, M W, Mazzola, A, Craxì, A, Petta, S, Stewart, G J, Liddle, C, George, J, Ahlenstiel, G, Booth, D R

“…Single-nucleotide polymorphisms near the interferon lambda 3 ( IFNL3 ) gene predict outcomes to infection and anti-viral treatment in hepatitis C virus (HCV)…”
Get full text

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis by Weltman, Martin D., Farrell, Geoffrey C., Hall, Pauline, Ingelman‐Sundberg, Magnus, Liddle, Christopher

“…Nonalcoholic steatohepatitis (NASH) has multiple etiologic associations, but the pathogenesis is poorly understood. Cytochrome P450 (CYP) 2E1 is induced in the…”
Get full text

Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent by O'Connor, K S, Parnell, G, Patrick, E, Ahlenstiel, G, Suppiah, V, van der Poorten, D, Read, S A, Leung, R, Douglas, M W, Yang, J YH, Stewart, G J, Liddle, C, George, J, Booth, D R

“…The IFNL3 genotype predicts the clearance of hepatitis C virus (HCV), spontaneously and with interferon (IFN)-based therapy. The responder genotype is…”
Get full text

Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation by Weltman, MD, Farrell, GC, Liddle, C

“…BACKGROUND & AIMS: Nonalcoholic steatohepatitis is morphologically identical to alcoholic hepatitis and has multiple etiologic associations and an unknown…”
Get full text

Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? by Hilmer, S. N., Seale, J. P., Le Couteur, D. G., Crampton, R., Liddle, C.

“…Aims: To assess ability of interns immediately before starting clinical practice in New South Wales (NSW) teaching hospitals to prescribe medications safely…”
Get full text

Proximity labeling reveals new functional relationships between meiotic recombination proteins in S. cerevisiae by Voelkel-Meiman, Karen, Liddle, Jennifer C, Balsbaugh, Jeremy L, MacQueen, Amy J

“…Several protein ensembles facilitate crossover recombination and the associated assembly of synaptonemal complex (SC) during meiosis. In yeast,…”
Get full text

Separate and interactive regulation of cytochrome P450 3a4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes by LIDDLE, C, GOODWIN, B. J, GEORGE, J, TAPNER, M, FARRELL, G. C

“…CYP3A4, the predominant cytochrome P450 expressed in human liver, is responsible for the metabolism of endogenous steroids and many drugs. On the basis of…”
Get full text

Dynamics of Protein Kinases: Insights from Nuclear Magnetic Resonance by Xiao, Yao, Liddle, Jennifer C, Pardi, Arthur, Ahn, Natalie G

“…Protein kinases are ubiquitous enzymes with critical roles in cellular processes and pathology. As a result, researchers have studied their activity and…”
Get full text

Voriconazole toxicity related to polymorphisms in CYP2C19 by Suan, D., O'Connor, K., Booth, D. R., Liddle, C., Stewart, G. J.

Get full text

Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies by Sharma, R, Kacevska, M, London, R, Clarke, S J, Liddle, C, Robertson, G

“…There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance…”
Get full text

A critical evaluation of the fish early-life stage toxicity test for engineered nanomaterials: experimental modifications and recommendations by Shaw, Benjamin J., Liddle, Corin C., Windeatt, Kirsten M., Handy, Richard D.

“…There are concerns that regulatory toxicity tests are not fit for purpose for engineered nanomaterials (ENMs) or need modifications. The aim of the current…”
Get full text

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2 by Pegram, Laurel M., Liddle, Jennifer C., Xiao, Yao, Hoh, Maria, Rudolph, Johannes, Iverson, Dylan B., Vigers, Guy P., Smith, Darin, Zhang, Hailong, Wang, Weiru, Moffat, John G., Ahn, Natalie G.

“…Conformational selection by small molecules expands inhibitory possibilities for protein kinases. Nuclear magnetic resonance (NMR) measurements of the…”
Get full text

Heat‐induced structural and chemical changes to a computationally designed miniprotein by Dudley, Joshua A., Park, Sojeong, Cho, Oliver, Wells, Nicholas G. M., MacDonald, Meagan E., Blejec, Katerina M., Fetene, Emmanuel, Zanderigo, Eric, Houliston, Scott, Liddle, Jennifer C., Dashnaw, Chad M., Sabo, T. Michael, Shaw, Bryan F., Balsbaugh, Jeremy L., Rocklin, Gabriel J., Smith, Colin A.

“…The de novo design of miniprotein inhibitors has recently emerged as a new technology to create proteins that bind with high affinity to specific therapeutic…”
Get full text