Search Results - "Liddiard, Kate"

Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages by Liddiard, Kate, Taylor, Philip R

“…Macrophages are responsive to local tissue signals and alter their phenotypes accordingly. In disease tissues this means that macrophage phenotypes may change…”
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Telomere fusions associate with coding sequence and copy number alterations in CLL by Escudero, Laura, Cleal, Kez, Ashelford, Kevin, Fegan, Chris, Pepper, Chris, Liddiard, Kate, Baird, Duncan M.

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DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase by Liddiard, Kate, Ruis, Brian, Kan, Yinan, Cleal, Kez, Ashelford, Kevin E, Hendrickson, Eric A, Baird, Duncan M

“…Abstract Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have…”
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Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent by Jones, Rhiannon E., Oh, Sehyun, Grimstead, Julia W., Zimbric, Jacob, Roger, Laureline, Heppel, Nicole H., Ashelford, Kevin E., Liddiard, Kate, Hendrickson, Eric A., Baird, Duncan M.

“…Short dysfunctional telomeres are capable of fusion, generating dicentric chromosomes and initiating breakage-fusion-bridge cycles. Cells that escape the…”
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The Induction of Inflammation by Dectin-1 In Vivo Is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis by Rosas, Marcela, Liddiard, Kate, Kimberg, Matti, Faro-Trindade, Ines, McDonald, Jacqueline U, Williams, David L, Brown, Gordon D, Taylor, Philip R

“…Dectin-1 is the archetypal signaling, non-Toll-like pattern recognition receptor that plays a protective role in immune defense to Candida albicans as the…”
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From hemangioblast to hematopoietic stem cell: An endothelial connection? by Jaffredo, Thierry, Nottingham, Wade, Liddiard, Kate, Bollerot, Karine, Pouget, Claire, de Bruijn, Marella

“…The developmental origin of hematopoietic stem cells has been the subject of much research. Now that the developmental link between the hematopoietic system…”
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Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions by Greaves, David R, Häkkinen, Tomi, Lucas, Andrew D, Liddiard, Kate, Jones, Emma, Quinn, Carmel M, Senaratne, Jawaharlal, Green, Fiona R, Tyson, Kerry, Boyle, Joe, Shanahan, Cathy, Weissberg, Peter L, Gordon, Siamon, Ylä-Hertualla, Seppo

“…ABSTRACT—Chemokines are important mediators of macrophage and T-cell recruitment in a number of inflammatory pathologies, and chemokines expressed in…”
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Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter by Liddiard, Kate, Welch, John S, Lozach, Jean, Heinz, Sven, Glass, Christopher K, Greaves, David R

“…Macrophages (Mtheta) play a central role in the innate immune response and in the pathology of chronic inflammatory diseases. Macrophages treated with Th2-type…”
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Shape-shifting macrophages by Liddiard, Kate, Taylor, Philip R

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Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4 by Liddiard, Kate, Ruis, Brian, Takasugi, Taylor, Harvey, Adam, Ashelford, Kevin E, Hendrickson, Eric A, Baird, Duncan M

“…Telomeres shorten with each cell division and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale genomic…”
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TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-dependent Mechanism by Welch, John S., Escoubet-Lozach, Laure, Sykes, David B., Liddiard, Kate, Greaves, David R., Glass, Christopher K.

“…The diverse functions of macrophages as participants in innate and acquired immune responses are regulated by the specific milieu of environmental factors,…”
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Macrophage heterogeneity and acute inflammation by Liddiard, Kate, Rosas, Marcela, Davies, Luke C., Jones, Simon A., Taylor, Philip R.

“…In this Viewpoint, we concentrate on the aspects of macrophage biology that we believe are fundamental for an appropriate contextual understanding of…”
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Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA damage response by Liddiard, Kate, Grimstead, Julia W, Cleal, Kez, Evans, Anna, Baird, Duncan M

“…Identifying attributes that distinguish pre-malignant from senescent cells provides opportunities for targeted disease eradication and revival of anti-tumour…”
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POLQ suppresses genome instability and alterations in DNA repeat tract lengths by Liddiard, Kate, Aston-Evans, Alys N, Cleal, Kez, Hendrickson, Eric A, Baird, Duncan M

“…DNA polymerase theta (POLQ) is a principal component of the alternative non-homologous end-joining (ANHEJ) DNA repair pathway that ligates DNA double-strand…”
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In vivo functional analysis and genetic modification of in vitro‐derived mouse neutrophils by McDonald, Jacqueline U., Cortini, Andrea, Rosas, Marcela, Fossati‐Jimack, Liliane, Ling, Guang Sheng, Lewis, Kimberley J., Dewitt, Sharon, Liddiard, Kate, Brown, Gordon D., Jones, Simon A., Hallett, Maurice B., Botto, Marina, Taylor, Philip R.

“…Mature neutrophils are notoriously short‐lived immune cells that cannot be genetically manipulated. Analysis of gene function therefore requires genetically…”
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Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia by Morgan, Rhys Gareth, Pearn, Lorna, Liddiard, Kate, Hills, Robert, Burnett, Alan, Tonks, Alex, Darley, Richard L

“…Abstract 1573 Wnt proteins are important developmental regulators and are known to play a role in maintenance of hematopoietic stem cells (HSC). Wnt signaling…”
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Alternative Runx1 promoter usage in mouse developmental hematopoiesis by Bee, Thomas, Liddiard, Kate, Swiers, Gemma, Bickley, Sorrel R.B., Vink, Chris S., Jarratt, Andrew, Hughes, Jim R., Medvinsky, Alexander, de Bruijn, Marella F.T.R.

“…The interest in stem cell based therapies has emphasized the importance of understanding the cellular and molecular mechanisms by which stem cells are…”
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The role and uses of antibodies in COVID-19 infections: a living review by Scourfield, D Oliver, Reed, Sophie G, Quastel, Max, Alderson, Jennifer, Bart, Valentina M T, Teijeira Crespo, Alicia, Jones, Ruth, Pring, Ellie, Richter, Felix Clemens, Burnell, Stephanie E A

“…Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current…”
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Mucosal immune responses in COVID19 - a living review by Pearson, Claire F, Jeffery, Rebecca, Thornton, Emily E

“…COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many…”
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T cell phenotypes in COVID-19 - a living review by Hanna, Stephanie J, Codd, Amy S, Gea-Mallorqui, Ester, Scourfield, D Oliver, Richter, Felix C, Ladell, Kristin, Borsa, Mariana, Compeer, Ewoud B, Moon, Owen R, Galloway, Sarah A E, Dimonte, Sandra, Capitani, Lorenzo, Shepherd, Freya R, Wilson, Joseph D, Uhl, Lion F K, Gallimore, Awen M, Milicic, Anita

“…COVID-19 is characterized by profound lymphopenia in the peripheral blood, and the remaining T cells display altered phenotypes, characterized by a spectrum of…”
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