Search Results - "Lichtman, Aron H"

Endocannabinoids Shape Accumbal Encoding of Cue-Motivated Behavior via CB1 Receptor Activation in the Ventral Tegmentum by Oleson, Erik B., Beckert, Michael V., Morra, Joshua T., Lansink, Carien S., Cachope, Roger, Abdullah, Rehab A., Loriaux, Amy L., Schetters, Dustin, Pattij, Tommy, Roitman, Mitchell F., Lichtman, Aron H., Cheer, Joseph F.

“…Transient increases in nucleus accumbens (NAc) dopamine concentration are observed when animals are presented with motivationally salient stimuli and are…”
Get full text

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory by Hait, Nitai C, Wise, Laura E, Allegood, Jeremy C, O'Brien, Megan, Avni, Dorit, Reeves, Thomas M, Knapp, Pamela E, Lu, Junyan, Luo, Cheng, Miles, Michael F, Milstien, Sheldon, Lichtman, Aron H, Spiegel, Sarah

“…Fingolimod is a sphingosine-1 phosphate (S1P) receptor modulator and an immune modulator in use as a treatment for the remitting-relapsing form of multiple…”
Get full text

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse by Toma, Wisam, Kyte, S. Lauren, Bagdas, Deniz, Alkhlaif, Yasmin, Alsharari, Shakir D., Lichtman, Aron H., Chen, Zhi-Jian, Del Fabbro, Egidio, Bigbee, John W., Gewirtz, David A., Damaj, M. Imad

“…Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer…”
Get full text

Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects by Kinsey, Steven G, Wise, Laura E, Ramesh, Divya, Abdullah, Rehab, Selley, Dana E, Cravatt, Benjamin F, Lichtman, Aron H

“…The monoacylglycerol lipase (MAGL) inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) produces…”
Get more information

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects by Cravatt, Benjamin F, Long, Jonathan Z, Li, Weiwei, Booker, Lamont, Burston, James J, Kinsey, Steven G, Schlosburg, Joel E, Pavón, Franciso J, Serrano, Antonia M, Selley, Dana E, Parsons, Loren H, Lichtman, Aron H

“…2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated…”
Get full text

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system by Kinsey, Steven G, Schlosburg, Joel E, Thomas, Elizabeth A, Cravatt, Benjamin F, Nomura, Daniel K, Selley, Dana E, Long, Jonathan Z, Sim-Selley, Laura J, Booker, Lamont, Liu, Qing-song, Blankman, Jacqueline L, Ramesh, Divya, Lichtman, Aron H, Nguyen, Peter T, Burston, James J, Pan, Bin

“…Scholsburg and colleagues show that prolonged inactivation of monoacylglycerol lipase, the principal degradative enzyme for the endocannabinoid…”
Get full text

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function by Cabral, Guy A., Rogers, Thomas J., Lichtman, Aron H.

“…Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in…”
Get full text

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators by Tseng, Chih-Chung, Baillie, Gemma, Donvito, Giulia, Mustafa, Mohammed A, Juola, Sophie E, Zanato, Chiara, Massarenti, Chiara, Dall’Angelo, Sergio, Harrison, William T. A, Lichtman, Aron H, Ross, Ruth A, Zanda, Matteo, Greig, Iain R

“…The first generation of CB1 positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs…”
Get full text

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain by Bagdas, Deniz, Wilkerson, Jenny L, Kulkarni, Abhijit, Toma, Wisam, AlSharari, Shakir, Gul, Zulfiye, Lichtman, Aron H, Papke, Roger L, Thakur, Ganesh A, Damaj, M Imad

“…Background and Purpose Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic…”
Get full text

Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy by Curry, Zachary A, Wilkerson, Jenny L, Bagdas, Deniz, Kyte, S Lauren, Patel, Nipa, Donvito, Giulia, Mustafa, Mohammed A, Poklis, Justin L, Niphakis, Micah J, Hsu, Ku-Lung, Cravatt, Benjamin F, Gewirtz, David A, Damaj, M Imad, Lichtman, Aron H

“…Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic pain side effects often persist long after treatment has ended…”
Get more information

Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice by Ignatowska-Jankowska, Bogna, Wilkerson, Jenny L, Mustafa, Mohammed, Abdullah, Rehab, Niphakis, Micah, Wiley, Jenny L, Cravatt, Benjamin F, Lichtman, Aron H

“…The endogenous cannabinoid 2-arachidonoylglycerol (2-AG) plays an important role in a variety of physiologic processes, but its rapid breakdown by…”
Get more information

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice by Yadav-Samudrala, Barkha J, Dodson, Hailey, Ramineni, Shreya, Kim, Elizabeth, Poklis, Justin L, Lu, Dai, Ignatowska-Jankowska, Bogna M, Lichtman, Aron H, Fitting, Sylvia

“…The cannabinoid receptor type 1 (CB1R) is a promising therapeutic target for various neurodegenerative diseases, including HIV-1-associated neurocognitive…”
Get full text

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo by Long, Jonathan Z, Nomura, Daniel K, Vann, Robert E, Walentiny, D. Matthew, Booker, Lamont, Jin, Xin, Burston, James J, Sim-Selley, Laura J, Lichtman, Aron H, Wiley, Jenny L, Cravatt, Benjamin F

“…Δ⁹-Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct cannabinoid receptor (CB1) agonists produce a number of…”
Get full text

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action by Viader, Andreu, Blankman, Jacqueline L., Zhong, Peng, Liu, Xiaojie, Schlosburg, Joel E., Joslyn, Christopher M., Liu, Qing-Song, Tomarchio, Aaron J., Lichtman, Aron H., Selley, Dana E., Sim-Selley, Laura J., Cravatt, Benjamin F.

“…The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG…”
Get full text

The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice by Wilkerson, Jenny L., Ghosh, Sudeshna, Mustafa, Mohammed, Abdullah, Rehab A., Niphakis, Micah J., Cabrera, Roberto, Maldonado, Rafael L., Cravatt, Benjamin F., Lichtman, Aron H.

“…Although opioids are highly efficacious analgesics, their abuse potential and other untoward side effects diminish their therapeutic utility. The addition of…”
Get full text

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice by Fitting, Sylvia, Ignatowska-Jankowska, Bogna M, Bull, Cecilia, Skoff, Robert P, Lichtman, Aron H, Wise, Laura E, Fox, Michael A, Su, Jianmin, Medina, Alexandre E, Krahe, Thomas E, Knapp, Pamela E, Guido, William, Hauser, Kurt F

“…Background Human immunodeficiency virus (HIV) associated neurocognitive disorders (HAND), including memory dysfunction, continue to be a major clinical…”
Get full text

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model by Ghosh, Sudeshna, Wise, Laura E., Chen, Yugang, Gujjar, Ramesh, Mahadevan, Anu, Cravatt, Benjamin F., Lichtman, Aron H.

“…The present study tested whether the selective monoacylglycerol lipase (MAGL) inhibitor JZL184 would reduce allodynia and paw edema in the carrageenan test…”
Get full text

GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration by Hermes, Douglas J., Yadav-Samudrala, Barkha J., Xu, Changqing, Paniccia, Jacqueline E., Meeker, Rick B., Armstrong, Michael L., Reisdorph, Nichole, Cravatt, Benjamin F., Mackie, Ken, Lichtman, Aron H., Ignatowska-Jankowska, Bogna M., Lysle, Donald T., Fitting, Sylvia

“…Human immunodeficiency virus type 1 (HIV-1) is known to provoke microglial immune responses which likely play a paramount role in the development of chronic…”
Get full text

C57BL/6 substrain differences in formalin-induced pain-like behavioral responses by Ulker, Esad, Caillaud, Martial, Patel, Trusha, White, Alyssa, Rashid, Danyal, Alqasem, Mashael, Lichtman, Aron H., Bryant, Camron D., Damaj, M. Imad

“…Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs,…”
Get full text

Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS by Hermes, Douglas J., Xu, Changqing, Poklis, Justin L., Niphakis, Micah J., Cravatt, Benjamin F., Mackie, Ken, Lichtman, Aron H., Ignatowska-Jankowska, Bogna M., Fitting, Sylvia

“…The HIV-1 transactivator of transcription (Tat) is a neurotoxin involved in the pathogenesis of HIV-1 associated neurocognitive disorders (HAND). The…”
Get full text