Search Results - "Lichti, Cheryl F."

Crinophagic granules in pancreatic β cells contribute to mouse autoimmune diabetes by diversifying pathogenic epitope repertoire by Hu, Hao, Vomund, Anthony N., Peterson, Orion J., Srivastava, Neetu, Li, Tiandao, Kain, Lisa, Beatty, Wandy L., Zhang, Bo, Hsieh, Chyi-Song, Teyton, Luc, Lichti, Cheryl F., Unanue, Emil R., Wan, Xiaoxiao

“…Autoimmune attack toward pancreatic β cells causes permanent loss of glucose homeostasis in type 1 diabetes (T1D). Insulin secretory granules store and secrete…”
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Genomic impact of transient low-dose decitabine treatment on primary AML cells by Klco, Jeffery M., Spencer, David H., Lamprecht, Tamara L., Sarkaria, Shawn M., Wylie, Todd, Magrini, Vincent, Hundal, Jasreet, Walker, Jason, Varghese, Nobish, Erdmann-Gilmore, Petra, Lichti, Cheryl F., Meyer, Matthew R., Townsend, R. Reid, Wilson, Richard K., Mardis, Elaine R., Ley, Timothy J.

“…Acute myeloid leukemia (AML) is characterized by dysregulated gene expression and abnormal patterns of DNA methylation; the relationship between these events…”
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Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence by Fentress, Sarah J, Behnke, Michael S, Dunay, Ildiko R, Mashayekhi, Mona, Rommereim, Leah M, Fox, Barbara A, Bzik, David J, Taylor, Gregory A, Turk, Benjamin E, Lichti, Cheryl F, Townsend, R Reid, Qiu, Wei, Hui, Raymond, Beatty, Wandy L, Sibley, L David

“…Macrophages are specialized to detect and destroy intracellular microbes and yet a number of pathogens have evolved to exploit this hostile niche. Here we…”
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PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease by Hsu, Wei-Chun J., Wildburger, Norelle C., Haidacher, Sigmund J., Nenov, Miroslav N., Folorunso, Oluwarotimi, Singh, Aditya K., Chesson, Brent C., Franklin, Whitney F., Cortez, Ibdanelo, Sadygov, Rovshan G., Dineley, Kelly T., Rudra, Jay S., Taglialatela, Giulio, Lichti, Cheryl F., Denner, Larry, Laezza, Fernanda

“…Cognitive impairment in humans with Alzheimer's disease (AD) and in animal models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor…”
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Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load by Nanaware, Padma P., Khan, Zohaib N., Clement, Cristina C., Shetty, Madhur, Mota, Ines, Seltzer, Ethan S., Dzieciatkowska, Monika, Gamboni, Fabia, D’Alessandro, Angelo, Ng, Charles, Nagayama, Manabu, Lichti, Cheryl F., Soni, Rajesh K., Jacob B. Geri, Matei, Irina, Lyden, David, Longman, Randy, Lu, Theresa T., Wan, Xiaoxiao, Unanue, Emil R., Stern, Lawrence J., Santambrogio, Laura

“…The lymphatic fluid is the conduit by which part of the tissue “omics” is transported to the draining lymph node for immunosurveillance. Following cannulation…”
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Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway by Scala, Federico, Nenov, Miroslav N., Crofton, Elizabeth J., Singh, Aditya K., Folorunso, Oluwarotimi, Zhang, Yafang, Chesson, Brent C., Wildburger, Norelle C., James, Thomas F., Alshammari, Musaad A., Alshammari, Tahani K., Elfrink, Hannah, Grassi, Claudio, Kasper, James M., Smith, Ashley E., Hommel, Jonathan D., Lichti, Cheryl F., Rudra, Jai S., D’Ascenzo, Marcello, Green, Thomas A., Laezza, Fernanda

“…Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes underlying excitability that are still poorly understood. Here, we…”
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The Haemophilus influenzae HMW1C protein is a glycosyltransferase that transfers hexose residues to asparagine sites in the HMW1 adhesin by Grass, Susan, Lichti, Cheryl F, Townsend, R Reid, Gross, Julia, St Geme, 3rd, Joseph W

“…The Haemophilus influenzae HMW1 adhesin is a high-molecular weight protein that is secreted by the bacterial two-partner secretion pathway and mediates…”
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ESI–MS/MS and MALDI-IMS Localization Reveal Alterations in Phosphatidic Acid, Diacylglycerol, and DHA in Glioma Stem Cell Xenografts by Wildburger, Norelle C., Wood, Paul L., Gumin, Joy, Lichti, Cheryl F., Emmett, Mark R., Lang, Frederick F., Nilsson, Carol L.

“…Glioblastoma (GBM) is the most common adult primary brain tumor. Despite aggressive multimodal therapy, the survival of patients with GBM remains dismal…”
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Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids by MAZUR, Anna, LICHTI, Cheryl F, PRATHER, Paul L, ZIELINSKA, Agnieszka K, BRATTON, Stacie M, GALLUS-ZAWADA, Anna, FINEL, Moshe, MILLER, Grover P, RADOMINSKA-PANDYA, Anna, MORAN, Jeffery H

“…Tetrahydrocannabinol (Δ 9 -THC), the primary psychoactive ingredient in marijuana, is subject to cytochrome P450 oxidation and subsequent…”
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Identification of spliced peptides in pancreatic islets uncovers errors leading to false assignments by Lichti, Cheryl F.

“…Proteasomal spliced peptides (PSPs) have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as…”
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Dynamic proteomics of nucleus accumbens in response to acute psychological stress in environmentally enriched and isolated rats by Fan, Xiuzhen, Li, Dingge, Lichti, Cheryl F, Green, Thomas A

“…Our prior research has shown that environmental enrichment (i.e. rats reared in an environment with novel objects, social contact with conspecifics) produces a…”
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Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy by Marozkina, Nadzeya V., Yemen, Sean, Borowitz, Molly, Liu, Lei, Plapp, Melissa, Sun, Fei, Islam, Rafique, Erdmann-Gilmore, Petra, Townsend, R. Reid, Lichti, Cheryl F., Mantri, Sneha, Clapp, Phillip W., Randell, Scott H., Gaston, Benjamin, Zaman, Khalequz, Stamler, Jonathan S.

“…The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating agents can cause full maturation of the abnormal gene product ΔF508…”
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Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example by Lichti, Cheryl F., Wan, Xiaoxiao

“…In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by…”
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Single point mutations result in the miss-sorting of Glut4 to a novel membrane compartment associated with stress granule proteins by Song, XiaoMei, Lichti, Cheryl F, Townsend, R Reid, Mueckler, Mike

“…Insulin increases cellular glucose uptake and metabolism in the postprandial state by acutely stimulating the translocation of the Glut4 glucose transporter…”
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MHC-II neoantigens shape tumour immunity and response to immunotherapy by Alspach, Elise, Lussier, Danielle M., Miceli, Alexander P., Kizhvatov, Ilya, DuPage, Michel, Luoma, Adrienne M., Meng, Wei, Lichti, Cheryl F., Esaulova, Ekaterina, Vomund, Anthony N., Runci, Daniele, Ward, Jeffrey P., Gubin, Matthew M., Medrano, Ruan F. V., Arthur, Cora D., White, J. Michael, Sheehan, Kathleen C. F., Chen, Alex, Wucherpfennig, Kai W., Jacks, Tyler, Unanue, Emil R., Artyomov, Maxim N., Schreiber, Robert D.

“…The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting 1 . Immunotherapies such as…”
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Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens by Lichti, Cheryl F, Fan, Xiuzhen, English, Robert D, Zhang, Yafang, Li, Dingge, Kong, Fanping, Sinha, Mala, Andersen, Clark R, Spratt, Heidi, Luxon, Bruce A, Green, Thomas A

“…Prior research demonstrated that environmental enrichment creates individual differences in behavior leading to a protective addiction phenotype in rats…”
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The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides by Wan, Xiaoxiao, Vomund, Anthony N., Peterson, Orion J., Chervonsky, Alexander V., Lichti, Cheryl F., Unanue, Emil R.

“…The nature of autoantigens that trigger autoimmune diseases has been much discussed, but direct biochemical identification is lacking for most. Addressing this…”
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Recent advances in immunopeptidomic-based tumor neoantigen discovery by Meng, Wei, Schreiber, Robert D, Lichti, Cheryl F

“…The role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we…”
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Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases by Zielinska, Agnieszka, Lichti, Cheryl F, Bratton, Stacie, Mitchell, Neil C, Gallus-Zawada, Anna, Le, Vi-Huyen, Finel, Moshe, Miller, Grover P, Radominska-Pandya, Anna, Moran, Jeffery H

“…Our understanding of human phase II metabolic pathways which facilitate detoxification and excretion of warfarin (Coumadin) is limited. The goal of this study…”
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Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4‐hydroxynonenal by Ayyadevara, Srinivas, Engle, Mark R., Singh, Sharda P., Dandapat, Abhijit, Lichti, Cheryl F., Beneš, Helen, Shmookler Reis, Robert J., Liebau, Eva, Zimniak, Piotr

“…Summary Caenorhabditis elegans expresses a glutathione transferase (GST) belonging to the Pi class, for which we propose the name CeGSTP2‐2. CeGSTP2‐2 (the…”
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