Search Results - "Licht, Ruud"

Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering by Siddappa, Ramakrishnaiah, Licht, Ruud, van Blitterswijk, Clemens, de Boer, Jan

“…The use of multipotent human mesenchymal stem cells (hMSCs) for tissue engineering has been a subject of extensive research. The donor variation in growth,…”
Get full text

Fiber diameter and texture of electrospun PEOT/PBT scaffolds influence human mesenchymal stem cell proliferation and morphology, and the release of incorporated compounds by Moroni, Lorenzo, Licht, Ruud, de Boer, Jan, de Wijn, Joost R., van Blitterswijk, Clemens A.

“…Electrospinning (ESP) has lately shown a great potential as a novel scaffold fabrication technique for tissue engineering. Scaffolds are produced by spinning a…”
Get full text

cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo by Siddappa, Ramakrishnaiah, Martens, Anton, Doorn, Joyce, Leusink, Anouk, Olivo, Cristina, Licht, Ruud, van Rijn, Linda, Gaspar, Claudia, Fodde, Riccardo, Janssen, Frank, van Blitterswijk, Clemens, de Boer, Jan

“…Tissue engineering of large bone defects is approached through implantation of autologous osteogenic cells, generally referred to as multipotent stromal cells…”
Get full text

Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1 by Mentink, Anouk, Hulsman, Marc, Groen, Nathalie, Licht, Ruud, Dechering, Koen J, van der Stok, Johan, Alves, Hugo A, Dhert, Wouter J, van Someren, Eugene P, Reinders, Marcel J.T, van Blitterswijk, Clemens A, de Boer, Jan

“…Abstract Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone…”
Get full text

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration by Smolders, Lucas A., Meij, Björn P., Riemers, Frank M., Licht, Ruud, Wubbolts, Richard, Heuvel, Douwe, Grinwis, Guy C.M., Vernooij, Hans C.M., Hazewinkel, Herman A.W., Penning, Louis C., Tryfonidou, Marianna A.

“…The notochordal cell (NC) of the nucleus pulposus (NP) is considered a potential NP progenitor cell, and early intervertebral disk (IVD) degeneration involves…”
Get full text

Applicability of a Newly Developed Bioassay for Determining Bioactivity of Anti-Inflammatory Compounds in Release Studies − Celecoxib and Triamcinolone Acetonide Released from Novel PLGA-Based Microspheres by Yang, Hsiao-yin, van Dijk, Maarten, Licht, Ruud, Beekhuizen, Michiel, van Rijen, Mattie, Janstål, Martina Källrot, Öner, F. Cumhur, Dhert, Wouter J. A., Schumann, Detlef, Creemers, Laura B.

“…Purpose : To develop a bio-assay for measuring long-term bioactivity of released anti-inflammatory compounds and to test the bioactivity of celecoxib (CXB) and…”
Get full text

Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells by Yang, Hsiao-yin, Vonk, Lucienne A., Licht, Ruud, van Boxtel, Antonetta M.G., Bekkers, Joris E.J., Kragten, Angela H.M., Hein, San, Varghese, Oommen P., Howard, Kenneth A., Cumhur Öner, F., Dhert, Wouter J.A., Creemers, Laura B.

“…[Display omitted] The application of RNA interference (RNAi) has great therapeutic potential for degenerative diseases of cartilaginous tissues by means of…”
Get full text

The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells by Liu, Jun, Someren, Eugene, Mentink, Anouk, Licht, Ruud, Dechering, Koen, van Blitterswijk, Clemens, de Boer, Jan

“…Human mesenchymal stem cells (hMSCs) are being considered for several areas of clinical therapy, due to their multipotent nature. For instance, osteogenic…”
Get full text

The Effect of a Cyclooxygenase 2 Inhibitor on Early Degenerated Human Nucleus Pulposus Explants by van Dijk, Bart, Potier, Esther, Licht, Ruud, Creemers, Laura, Ito, Keita

“…Study Design Preclinical in vitro culture of human degenerated nucleus pulposus (NP) tissue. Objective Cyclooxygenase 2 inhibitors (e.g., celecoxib) inhibit…”
Get full text

Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis by Berden, Jo H.M, Licht, Ruud, van Bruggen, Mieke C.J, Tax, Wil J.M

“…The cardinal feature of systemic lupus erythematosus is the formation of anti-nuclear antibodies. In recent years, it has become clear that the nucleosome is a…”
Get full text

Inhibition of histone acetylation as a tool in bone tissue engineering by de Boer, Jan, Licht, Ruud, Bongers, Marloes, van der Klundert, Tessa, Arends, Roel, van Blitterswijk, Clemens

“…Our approach to bone tissue engineering is the in vitro expansion and osteogenic differentiation of bone marrow-derived human mesenchymal stem cells (hMSCs)…”
Get more information