Search Results - "Liberti, Sascha E."

Instability throughout the Saccharomyces cerevisiae genome resulting from Pms1 endonuclease deficiency by Lujan, Scott A, Garbacz, Marta A, Liberti, Sascha E, Burkholder, Adam B, Kunkel, Thomas A

“…Abstract The endonuclease activity of Pms1 directs mismatch repair by generating a nick in the newly replicated DNA strand. Inactivating Pms2, the human…”
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Stalled replication forks generate a distinct mutational signature in yeast by Larsen, Nicolai B., Liberti, Sascha E., Vogel, Ivan, Jørgensen, Signe W., Hickson, Ian D., Mankouri, Hocine W.

“…Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in…”
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Esc2 promotes telomere stability in response to DNA replication stress by Jørgensen, Signe W, Liberti, Sascha E, Larsen, Nicolai B, Lisby, Michael, Mankouri, Hocine W, Hickson, Ian D

“…Abstract Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form…”
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Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae by St Charles, Jordan A., Liberti, Sascha E., Williams, Jessica S., Lujan, Scott A., Kunkel, Thomas A.

“…•The base selectivity of the major replicases in vivo is higher than measured in vitro.•A variable balance between proofreading and MMR underlies replication…”
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Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro by Liu, Dekang, Frederiksen, Jane H, Liberti, Sascha E, Lützen, Anne, Keijzers, Guido, Pena-Diaz, Javier, Rasmussen, Lene Juel

“…DNA mismatch repair (MMR) is a highly-conserved DNA repair mechanism, whose primary role is to remove DNA replication errors preventing them from manifesting…”
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Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α by Liberti, Sascha E., Larrea, Andres A., Kunkel, Thomas A.

“…► Exo1 preferentially excises lagging strand replication errors during MMR. ► Exo1 more efficiently repairs Pol α replication errors compared to Pol δ errors…”
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Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks by Liberti, Sascha E., Andersen, Sofie D., Wang, Jing, May, Alfred, Miron, Simona, Perderiset, Mylene, Keijzers, Guido, Nielsen, Finn C., Charbonnier, Jean-Baptiste, Bohr, Vilhelm A., Rasmussen, Lene J.

“…Human exonuclease 1 (hEXO1) is implicated in DNA metabolism, including replication, recombination and repair, substantiated by its interactions with PCNA, DNA…”
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