Search Results - "Liberman, C"

Blast-induced cochlear synaptopathy in chinchillas by Hickman, T. T., Smalt, C., Bobrow, J., Quatieri, T., Liberman, M. C.

“…When exposed to continuous high-level noise, cochlear neurons are more susceptible to damage than hair cells (HCs): exposures causing temporary threshold…”
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Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells by Liberman, Ana C, Budziñski, Maia L, Sokn, Clara, Gobbini, Romina Paula, Steininger, Anja, Arzt, Eduardo

“…Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory…”
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Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear by Wu, P.Z., Liberman, L.D., Bennett, K., de Gruttola, V., O'Malley, J.T., Liberman, M.C.

“…•Hair-cell and auditory-nerve loss were quantified in 20 “normal” humans 0–86 yrs.•Age-related loss of nerve fibers exceeded the rate of hair cell loss by…”
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RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity by Druker, Jimena, Liberman, Ana C., Antunica-Noguerol, María, Gerez, Juan, Paez-Pereda, Marcelo, Rein, Theo, Iñiguez-Lluhí, Jorge A., Holsboer, Florian, Arzt, Eduardo

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51 by Antunica-Noguerol, M, Budziñski, M L, Druker, J, Gassen, N C, Sokn, M C, Senin, S, Aprile-Garcia, F, Holsboer, F, Rein, T, Liberman, A C, Arzt, E

“…FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of…”
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Stress, alcohol and infection during early development: A brief review of common outcomes and mechanisms by Surkin, P. N., Brenhouse, H., Deak, T., Liberman, A. C., Lasaga, M.

“…Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or…”
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Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function by Aprile-Garcia, Fernando, Metzger, Michael W, Paez-Pereda, Marcelo, Stadler, Herbert, Acuña, Matías, Liberman, Ana C, Senin, Sergio A, Gerez, Juan, Hoijman, Esteban, Refojo, Damian, Mitkovski, Mišo, Panhuysen, Markus, Stühmer, Walter, Holsboer, Florian, Deussing, Jan M, Arzt, Eduardo

“…The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg)…”
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Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells by Liberman, Ana C, Antunica-Noguerol, Maria, Ferraz-de-Paula, Viviane, Palermo-Neto, Joao, Castro, Carla N, Druker, Jimena, Holsboer, Florian, Perone, Marcelo J, Gerlo, Sarah, De Bosscher, Karolien, Haegeman, Guy, Arzt, Eduardo

“…Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating…”
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activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction by Liberman, Ana C, Refojo, Damian, Druker, Jimena, Toscano, Marta, Rein, Theo, Holsboer, Florian, Arzt, Eduardo

“…Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including activating protein (AP)-1, NF-κB, and NFAT. GCs…”
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Otoacoustic emissions without somatic motility: Can stereocilia mechanics drive the mammalian cochlea? by LIBERMAN, M. C, JIAN ZUO, GUINAN, J. J

“…Distortion product otoacoustic emissions (DPOAEs) evoked by low-level tones are a sensitive indicator of outer hair cell (OHC) function. High-level DPOAEs are…”
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Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing by Hickman, Tyler T, Liberman, M Charles, Jacob, Michele H

“…Normal hearing requires proper differentiation of afferent ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) that carry…”
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Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype by Liberman, M C, Tartaglini, E, Fleming, J C, Neufeld, E J

“…Mutations in the gene coding for the high-affinity thiamine transporter Slc19a2 underlie the clinical syndrome known as thiamine-responsive megaloblastic…”
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Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta) by Valero, M.D., Burton, J.A., Hauser, S.N., Hackett, T.A., Ramachandran, R., Liberman, M.C.

“…Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate…”
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SUMO regulation of FKBP51 activity and the stress response by Gobbini, Romina P, Velardo, Vanina Giselle, Sokn, Clara, Liberman, Ana C, Arzt, Eduardo

“…Glucocorticoids (GCs) actions are mostly mediated by the GC receptor (GR), a member of the nuclear receptor superfamily. Alterations of the GR activity have…”
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Antimasking effects of the olivocochlear reflex. II. Enhancement of auditory-nerve response to masked tones by Kawase, T, Delgutte, B, Liberman, M C

“…1. The antimasking effects of olivocochlear (OC) efferent feedback were studied in anesthetized or decerebrate cats by comparing responses of single…”
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Intracellular Molecular Signaling by Liberman, Ana C., Druker, Jimena, Garcia, Fernando Aprile, Holsboer, Florian, Arzt, Eduardo

“…The molecular interaction between hormonal and cytokine signals is crucial for providing specificity to their actions and represents a key step for…”
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Antimasking effects of the olivocochlear reflex. I. Enhancement of compound action potentials to masked tones by Kawase, T, Liberman, M C

“…1. The effects of olivocochlear (OC) feedback on signal processing in the cochlea were studied by comparing responses seen with and without a contralateral…”
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Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity by Budziñski, Maia L., Sokn, Clara, Gobbini, Romina, Ugo, Belén, Antunica-Noguerol, María, Senin, Sergio, Bajaj, Thomas, Gassen, Nils C., Rein, Theo, Schmidt, Mathias V., Binder, Elisabeth B., Arzt, Eduardo, Liberman, Ana C.

“…FKBP51 is an important inhibitor of the glucocorticoid receptor (GR) signaling. High FKBP51 levels are associated to stress-related disorders, which are linked…”
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Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing by Geerardyn, Alexander, Zhu, MengYu, Wu, Peizhe, O'Malley, Jennifer T., Nadol, Joseph B., Liberman, M. Charles, Nakajima, Hideko Heidi, Verhaert, Nicolas, Quesnel, Alicia M.

“…•After cochlear implantation via cochleostomy, intracochlear fibrosis and neoossification appear at anatomical locations that could impact normal inner ear…”
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Circulating iodide concentrations during and after pregnancy by LIBERMAN, C. S, PINO, S. C, SHIH LIEH FANG, BRAVERMAN, L. E, EMERSON, C. H

“…Early, indirect studies suggested that an important aspect of thyroid economy during pregnancy was a decline in plasma or serum inorganic iodide (PII)…”
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