Search Results - "Libby, Brian"

Positional Cloning and Characterization of Mei1, a Vertebrate-Specific Gene Required for Normal Meiotic Chromosome Synapsis in Mice by Libby, Brian J., Reinholdt, Laura G., Schimenti, John C.

“…The mouse meiotic mutant Mei1 was isolated in a screen for infertile mice descended from chemically mutagenized embryonic stem cells. Homozygotes of both sexes…”
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Loss of srf-3-encoded Nucleotide Sugar Transporter Activity in Caenorhabditis elegans Alters Surface Antigenicity and Prevents Bacterial Adherence by Jörg Höflich, Patricia Berninsone, Christine Göbel, Maria J. Gravato-Nobre, Brian J. Libby, Creg Darby, Samuel M. Politz, Jonathan Hodgkin, Carlos B. Hirschberg, Ralf Baumeister

“…During the establishment of a bacterial infection, the surface molecules of the host organism are of particular importance, since they mediate the first…”
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Rapid Detection and Molecular Serotyping of Adenovirus by Use of PCR Followed by Electrospray Ionization Mass Spectrometry by Blyn, Lawrence B, Hall, Thomas A, Libby, Brian, Ranken, Raymond, Sampath, Rangarajan, Rudnick, Karl, Moradi, Emily, Desai, Anjali, Metzgar, David, Russell, Kevin L, Freed, Nikki E, Balansay, Melinda, Broderick, Michael P, Osuna, Miguel A, Hofstadler, Steven A, Ecker, David J

“…We have developed a PCR/electrospray ionization mass spectrometry (PCR/ESI-MS) assay for the rapid detection, identification, and serotyping of human…”
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The Mouse Meiotic Mutation mei1 Disrupts Chromosome Synapsis with Sexually Dimorphic Consequences for Meiotic Progression by Libby, Brian J., De La Fuente, Rabindranath, O'Brien, Marilyn J., Wigglesworth, Karen, Cobb, John, Inselman, Amy, Eaker, Shannon, Handel, Mary Ann, Eppig, John J., Schimenti, John C.

“…mei1 (meiosis defective 1) is the first meiotic mutation in mice derived by phenotype-driven mutagenesis. It was isolated by using a novel technology in which…”
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Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry by Eshoo, Mark W, Whitehouse, Chris A, Nalca, Aysegul, Zoll, Scott, Ecker, Joseph A, Hall, Thomas A, Pennella, Thuy-Trang D, Duncan, David D, Desai, Anjali, Moradi, Emily K, Rudnick, Karl, Libby, Brian, Ranken, Raymond, Sampath, Rangarajan, Hofstadler, Steven A, Ecker, David J, Blyn, Lawrence B

“…The genus Orthopoxvirus contains several species of related viruses, including the causative agent of smallpox (Variola virus). In addition to smallpox,…”
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Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist by Liverton, Nigel J, Bednar, Rodney A, Bednar, Bohumil, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Cunningham, Michael, DiLella, Anthony G, Gaul, Stanley L, Libby, Brian E, Lyle, Elizabeth A, Lynch, Joseph J, McCauley, John A, Mosser, Scott D, Nguyen, Kevin T, Stump, Gary L, Sun, Hong, Wang, Hao, Yergey, James, Koblan, Kenneth S

“…The discovery of a novel series of NR2B subtype selective N-methyl-d-aspartate (NMDA) antagonists is reported. Initial optimization of a high-throughput…”
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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase by Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J

“…Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays…”
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Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists by Nguyen, Kevin T., Claiborne, Christopher F., McCauley, John A., Libby, Brian E., Claremon, David A., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Connolly, Thomas M., Condra, Cindra L., Bednar, Bohumil, Stump, Gary L., Lynch, Joseph J., Koblan, Kenneth S., Liverton, Nigel J.

“…A novel series of cyclic benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 29 is orally active in a…”
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Toward the Genetics of Mammalian Reproduction: Induction and Mapping of Gametogenesis Mutants in Mice by WARD, Jeremy O, REINHOLDT, Laura G, SCHIMENTI, John C, HARTFORD, Suzanne A, WILSON, Lawriston A, MUNROE, Robert J, SCHIMENTI, Kerry J, LIBBY, Brian J, O'BRIEN, Marilyn, PENDOLA, Janice K, EPPIG, John

“…The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility. To further the discovery of…”
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Mouse mutants from chemically mutagenized embryonic stem cells by Schimenti, John C, Munroe, Robert J, Bergstrom, Rebecca A, Y Zheng, Qing, Libby, Brian, Smith, Richard, John, Simon W.M, Schimenti, Kerry J, Browning, Victoria L

“…The drive to characterize functions of human genes on a global scale has stimulated interest in large-scale generation of mouse mutants. Conventional germ-cell…”
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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel by Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.

“…A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The…”
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Orally Efficacious NR2B-Selective NMDA Receptor Antagonists by Claiborne, Christopher F, McCauley, John A, Libby, Brian E, Curtis, Neil R, Diggle, Helen J, Kulagowski, Janusz J, Michelson, Stuart R, Anderson, Kenneth D, Claremon, David A, Freidinger, Roger M, Bednar, Rodney A, Mosser, Scott D, Gaul, Stanley L, Connolly, Thomas M, Condra, Cindra L, Bednar, Bohumil, Stump, Gary L, Lynch, Joseph J, Macaulay, Alison, Wafford, Keith A, Koblan, Kenneth S, Liverton, Nigel J

“…A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a…”
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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide by Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh

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Microdroplet-based PCR enrichment for large-scale targeted sequencing by Link, Darren R, Frazer, Kelly A, Tewhey, Ryan, Warner, Jason B, Nakano, Masakazu, Libby, Brian, Medkova, Martina, David, Patricia H, Kotsopoulos, Steve K, Samuels, Michael L, Hutchison, J Brian, Larson, Jonathan W, Topol, Eric J, Weiner, Michael P, Harismendy, Olivier, Olson, Jeff

“…In many sequencing applications, it is sufficient to sequence selected portions of a genome rather than the complete genome. Tewhey et al . describe an…”
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Toward the Genetics of Mammalian Reproduction: Induction and Mapping of Gametogenesis Mutants in Mice1 by Ward, Jeremy O, Reinholdt, Laura G, Hartford, Suzanne A, Wilson, Lawriston A, Munroe, Robert J, Schimenti, Kerry J, Libby, Brian J, O’Brien, Marilyn, Pendola, Janice K, Eppig, John, Schimenti, John C

“…The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility. To further the discovery of…”
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Cyclopentene Synthesis from 1,3-Dienes via Base-Induced Ring Contraction of 3,6-Dihydro-2H-thiopyrans:  Studies on Diastereoselection and Mechanism by Larsen, Scott D, Fisher, Peter V, Libby, Brian E, Jensen, Randy M, Mizsak, Stephen A, Watt, William, Ronk, Warren R, Hill, Scott T

“…An investigation of the scope and mechanism of a new synthesis of cyclopentenes from 3,6-dihydro-2H-thiopyrans is described. Alkyl halides substituted with an…”
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Global surveillance of emerging Influenza virus genotypes by mass spectrometry by Sampath, Rangarajan, Russell, Kevin L, Massire, Christian, Eshoo, Mark W, Harpin, Vanessa, Blyn, Lawrence B, Melton, Rachael, Ivy, Cristina, Pennella, Thuy, Li, Feng, Levene, Harold, Hall, Thomas A, Libby, Brian, Fan, Nancy, Walcott, Demetrius J, Ranken, Raymond, Pear, Michael, Schink, Amy, Gutierrez, Jose, Drader, Jared, Moore, David, Metzgar, David, Addington, Lynda, Rothman, Richard, Gaydos, Charlotte A, Yang, Samuel, St George, Kirsten, Fuschino, Meghan E, Dean, Amy B, Stallknecht, David E, Goekjian, Ginger, Yingst, Samuel, Monteville, Marshall, Saad, Magdi D, Whitehouse, Chris A, Baldwin, Carson, Rudnick, Karl H, Hofstadler, Steven A, Lemon, Stanley M, Ecker, David J

“…Effective influenza surveillance requires new methods capable of rapid and inexpensive genomic analysis of evolving viral species for pandemic preparedness, to…”
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Rapid Identification and Strain-Typing of Respiratory Pathogens for Epidemic Surveillance by Ecker, David J., Sampath, Rangarajan, Blyn, Lawrence B., Eshoo, Mark W., Ivy, Cristina, Ecker, Joseph A., Libby, Brian, Samant, Vivek, Sannes-Lowery, Kristin A., Melton, Rachael E., Russell, Kevin, Freed, Nikki, Barrozo, Chris, Wu, Jianguo, Rudnick, Karl, Desai, Anjali, Moradi, Emily, Knize, Duane J., Robbins, David W., Hannis, James C., Harrell, Patina M., Massire, Christian, Hall, Thomas A., Jiang, Yun, Ranken, Raymond, Drader, Jared J., White, Neill, McNeil, John A., Crooke, Stanley T., Hofstadler, Steven A., Falkow, Stanley

“…Epidemic respiratory infections are responsible for extensive morbidity and mortality within both military and civilian populations. We describe a…”
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TIGER: the universal biosensor by Hofstadler, Steven A., Sampath, Rangarajan, Blyn, Lawrence B., Eshoo, Mark W., Hall, Thomas A., Jiang, Yun, Drader, Jared J., Hannis, James C., Sannes-Lowery, Kristin A., Cummins, Lendell L., Libby, Brian, Walcott, Demetrius J., Schink, Amy, Massire, Christian, Ranken, Raymond, Gutierrez, Jose, Manalili, Sheri, Ivy, Cristina, Melton, Rachael, Levene, Harold, Barrett-Wilt, Greg, Li, Feng, Zapp, Vanessa, White, Neill, Samant, Vivek, McNeil, John A., Knize, Duane, Robbins, David, Rudnick, Karl, Desai, Anjali, Moradi, Emily, Ecker, David J.

“…In this work, we describe a strategy for the detection and characterization of microorganisms associated with a potential biological warfare attack or a…”
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Making His Mark by Brian, Libby

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