Search Results - "Libby, Andrew"

Nuclear receptors in the kidney during health and disease by Libby, Andrew E., Jones, Bryce, Lopez-Santiago, Isabel, Rowland, Emma, Levi, Moshe

“…Over the last 30 years, nuclear receptors (NRs) have been increasingly recognized as key modulators of systemic homeostasis and as contributing factors in many…”
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Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome by Libby, Andrew E., Bales, Elise, Orlicky, David J., McManaman, James L.

“…Perilipin-2 (PLIN2) is a constitutively associated cytoplasmic lipid droplet coat protein that has been implicated in fatty liver formation in non-alcoholic…”
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Learning the ABCs of ATP release by Libby, Andrew E., Jones, Bryce, Levi, Moshe

“…ATP plays important roles outside the cell, but the mechanism by which it is arrives in the extracellular environment is not clear. Dunn et al. now show that…”
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Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions by Orlicky, David J., Libby, Andrew E., Bales, Elise S., McMahan, Rachel H., Monks, Jenifer, Rosa, Francisco G., McManaman, James L.

“…Key points Wild‐type mice and mice with hepatocyte‐specific or whole‐body deletions of perilipin‐2 (Plin2) were used to define hepatocyte and extra‐hepatocyte…”
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Advances in fluorescence microscopy techniques to study kidney function by Ranjit, Suman, Lanzanò, Luca, Libby, Andrew E., Gratton, Enrico, Levi, Moshe

“…Fluorescence microscopy, in particular immunofluorescence microscopy, has been used extensively for the assessment of kidney function and pathology for both…”
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Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature by Libby, Andrew E., Bales, Elise S., Monks, Jenifer, Orlicky, David J., McManaman, James L.

“…Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets. In the current study,…”
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Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice by Takahashi, Shogo, Luo, Yuhuan, Ranjit, Suman, Xie, Cen, Libby, Andrew E., Orlicky, David J., Dvornikov, Alexander, Wang, Xiaoxin X., Myakala, Komuraiah, Jones, Bryce A., Bhasin, Kanchan, Wang, Dong, McManaman, James L., Krausz, Kristopher W., Gratton, Enrico, Ir, Diana, Robertson, Charles E., Frank, Daniel N., Gonzalez, Frank J., Levi, Moshe

“…Nonalcoholic fatty liver disease is a rapidly rising problem in the 21st century and is a leading cause of chronic liver disease that can lead to end-stage…”
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The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice by Wang, Xiaoxin X., Xie, Cen, Libby, Andrew E., Ranjit, Suman, Levi, Jonathan, Myakala, Komuraiah, Bhasin, Kanchan, Jones, Bryce A., Orlicky, David J., Takahashi, Shogo, Dvornikov, Alexander, Kleiner, David E., Hewitt, Stephen M., Adorini, Luciano, Kopp, Jeffrey B., Krausz, Kristopher W., Rosenberg, Avi, McManaman, James L., Robertson, Charles E., Ir, Diana, Frank, Daniel N., Luo, Yuhuan, Gonzalez, Frank J., Gratton, Enrico, Levi, Moshe

“…Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the US, partly due to the increasing incidence of metabolic syndrome, obesity,…”
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Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney by Wang, Xiaoxin X, Myakala, Komuraiah, Libby, Andrew E, Krawczyk, Ewa, Panov, Julia, Jones, Bryce A, Bhasin, Kanchan, Shults, Nataliia, Qi, Yue, Krausz, Kristopher W, Zerfas, Patricia M, Takahashi, Shogo, Daneshpajouhnejad, Parnaz, Titievsky, Avi, Taranenko, Elizaveta, Billon, Cyrielle, Chatterjee, Arindam, Elgendy, Bahaa, Walker, John K, Albanese, Chris, Kopp, Jeffrey B, Rosenberg, Avi Z, Gonzalez, Frank J, Guha, Udayan, Brodsky, Leonid, Burris, Thomas P, Levi, Moshe

“…A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging, per se, concurrent metabolic syndrome and hypertension,…”
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Lipoprotein lipase is an important modulator of lipid uptake and storage in hypothalamic neurons by Libby, Andrew E., Wang, Hong, Mittal, Richa, Sungelo, Mitchell, Potma, Eric, Eckel, Robert H.

“…LPL is the rate-limiting enzyme for uptake of TG-derived FFA in peripheral tissues, and the enzyme is expressed in the brain and CNS. We previously created a…”
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Effects of follicle-stimulating hormone on energy balance and tissue metabolic health after loss of ovarian function by Libby, Andrew E, Solt, Claudia M, Jackman, Matthew R, Sherk, Vanessa D, Foright, Rebecca M, Johnson, Ginger C, Nguyen, Thi-Tina, Breit, Matthew J, Hulett, Nicholas, Rudolph, Michael C, Roberson, Paul A, Wellberg, Elizabeth A, Jambal, Purevsuren, Scalzo, Rebecca L, Higgins, Janine, Kumar, T Rajendra, Wierman, Margaret E, Pan, Zhaoxing, Shankar, Kartik, Klemm, Dwight J, Moreau, Kerrie L, Kohrt, Wendy M, MacLean, Paul S

“…Loss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E ),…”
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Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice by Gavin, Kathleen M, Sullivan, Timothy M, Maltzahn, Joanne K, Jackman, Matthew R, Libby, Andrew E, MacLean, Paul S, Kohrt, Wendy M, Majka, Susan M, Klemm, Dwight J

“…A subpopulation of adipocytes in the major adipose depots of mice is produced from hematopoietic stem cells rather than mesenchymal progenitors that are the…”
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Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice by Kurtz, Ryan, Libby, Andrew, Jones, Bryce A, Myakala, Komuraiah, Wang, Xiaoxin, Lee, Yichien, Knoer, Grace, Lo Cascio, Julia N, McCormack, Michaela, Nguyen, Grace, Choos, Elijah N D, Rodriguez, Olga, Rosenberg, Avi Z, Ranjit, Suman, Albanese, Christopher, Levi, Moshe, Ecelbarger, Carolyn M, Shepard, Blythe D

“…Sodium-glucose co-transporters (SGLTs) serve to reabsorb glucose in the kidney. Recently, these transporters, mainly SGLT2, have emerged as new therapeutic…”
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Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland by Monks, Jenifer, Orlicky, David J, Libby, Andrew E, Dzieciatkowska, Monica, Ladinsky, Mark S, McManaman, James L

“…Secretory epithelial cells (sMEC) in mammary glands of lactating animals secrete lipids by a novel apocrine mechanism in which cytoplasmic lipid droplets (LD)…”
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Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers by Liggett, Jedson R, Kang, Jiman, Ranjit, Suman, Rodriguez, Olga, Loh, Katrina, Patil, Digvijay, Cui, Yuki, Duttargi, Anju, Nguyen, Sang, He, Britney, Lee, Yichien, Oza, Kesha, Frank, Brett S, Kwon, DongHyang, Li, Heng-Hong, Kallakury, Bhaskar, Libby, Andrew, Levi, Moshe, Robson, Simon C, Fishbein, Thomas M, Cui, Wanxing, Albanese, Chris, Khan, Khalid, Kroemer, Alexander

“…Type 1 Natural Killer T-cells (NKT1 cells) play a critical role in mediating hepatic ischemia-reperfusion injury (IRI). Although hepatic steatosis is a major…”
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Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency by Gadek, Katherine E, Wang, Hong, Hall, Monica N, Sungello, Mitchell, Libby, Andrew, MacLaskey, Drew, Eckel, Robert H, Olwin, Bradley B

“…Excessive circulating triglycerides due to reduction or loss of lipoprotein lipase activity contribute to hypertriglyceridemia and increased risk for…”
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Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction by Monks, Jenifer, Orlicky, David J., Stefanski, Adrianne L., Libby, Andrew E., Bales, Elise S., Rudolph, Michael C., Johnson, Ginger C., Sherk, Vanessa D., Jackman, Matthew R., Williamson, Kayla, Carlson, Nichole E., MacLean, Paul S., McManaman, James L.

“…Background/Objectives The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother’s dietary choices…”
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Neuronal Lipoprotein Lipase Deficiency Alters Neuronal Function and Hepatic Metabolism by Bruce, Kimberley D, Dobrinskikh, Evgenia, Wang, Hong, Rudenko, Ivan, Gao, Hong, Libby, Andrew E, Gorkhali, Sachi, Yu, Tian, Zsombok, Andrea, Eckel, Robert H

“…The autonomic regulation of hepatic metabolism offers a novel target for the treatment of non-alcoholic fatty liver disease (NAFLD). However, the molecular…”
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27558 Obeticholic acid (OCALIVA ®) protects against 2,8-dihydroxyadenine nephropathy in mice by Jones, Bryce, Benitez, Carlos, Cruz, Idalia, Myakala, Komuraiah, Wang, Xiaoxin, Libby, Andrew, Rowland, Emma, Kurtz, Ryan, Rosenberg, Avi, Levi, Moshe

“…ABSTRACT IMPACT: This work may lead to new treatments for crystalline nephropathies. OBJECTIVES/GOALS: This study investigated obeticholic acid (OCALIVA ®) as…”
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4528 Sirtuin 3 activation as a potential renoprotective therapy in a mouse model of Alport syndrome by Jones, Bryce, Myakala, Komuraiah, Wang, Xiaoxin, Libby, Andrew, Takahashi, Shogo, Bhasin, Kanchan, Ranjit, Suman, Rosenberg, Avi, Levi, Moshe

“…OBJECTIVES/GOALS: Sirtuin 3 (Sirt3), a mitochondrial NAD + -dependent deacetylase, is decreased in diverse models of kidney disease, and Sirt3 activation…”
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