Search Results - "Liau, B."

Insulator dysfunction and oncogene activation in IDH mutant gliomas by Flavahan, William A., Drier, Yotam, Liau, Brian B., Gillespie, Shawn M., Venteicher, Andrew S., Stemmer-Rachamimov, Anat O., Suvà, Mario L., Bernstein, Bradley E.

“…An epigenetic mechanism in which gain-of-function IDH mutations promote gliomagenesis by disrupting chromosomal topology is presented, with IDH mutations…”
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Mediator kinase inhibition further activates super-enhancer-associated genes in AML by Pelish, Henry E., Liau, Brian B., Nitulescu, Ioana I., Tangpeerachaikul, Anupong, Poss, Zachary C., Da Silva, Diogo H., Caruso, Brittany T., Arefolov, Alexander, Fadeyi, Olugbeminiyi, Christie, Amanda L., Du, Karrie, Banka, Deepti, Schneider, Elisabeth V., Jestel, Anja, Zou, Ge, Si, Chong, Ebmeier, Christopher C., Bronson, Roderick T., Krivtsov, Andrei V., Myers, Andrew G., Kohl, Nancy E., Kung, Andrew L., Armstrong, Scott A., Lemieux, Madeleine E., Taatjes, Dylan J., Shair, Matthew D.

“…A small-molecule inhibitor of the Mediator-associated kinases CDK8 and CDK19 inhibits growth of acute myeloid leukaemia (AML) cells and induces upregulation of…”
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Transcription elongation factors represent in vivo cancer dependencies in glioblastoma by Miller, Tyler E., Liau, Brian B., Wallace, Lisa C., Morton, Andrew R., Xie, Qi, Dixit, Deobrat, Factor, Daniel C., Kim, Leo J. Y., Morrow, James J., Wu, Qiulian, Mack, Stephen C., Hubert, Christopher G., Gillespie, Shawn M., Flavahan, William A., Hoffmann, Thomas, Thummalapalli, Rohit, Hemann, Michael T., Paddison, Patrick J., Horbinski, Craig M., Zuber, Johannes, Scacheri, Peter C., Bernstein, Bradley E., Tesar, Paul J., Rich, Jeremy N.

“…An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell…”
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A Unified Strategy for the Synthesis of 7‑Membered-Ring-Containing Lycopodium Alkaloids by Lee, Amy S, Liau, Brian B, Shair, Matthew D

“…A unique subset of the Lyco­podium alkaloid natural products share a 7-membered-ring substructure and may potentially arise from a common biosynthetic…”
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Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery by Siegenfeld, Allison P., Roseman, Shelby A., Roh, Heejin, Lue, Nicholas Z., Wagen, Corin C., Zhou, Eric, Johnstone, Sarah E., Aryee, Martin J., Liau, Brian B.

“…The genome can be divided into two spatially segregated compartments, A and B, which partition active and inactive chromatin states. While constitutive…”
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Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis by Kato, Shinichiro, Weng, Qing Yu, Insco, Megan L, Chen, Kevin Y, Muralidhar, Sathya, Pozniak, Joanna, Diaz, Joey Mark S, Drier, Yotam, Nguyen, Nhu, Lo, Jennifer A, van Rooijen, Ellen, Kemeny, Lajos V, Zhan, Yao, Feng, Yang, Silkworth, Whitney, Powell, C Thomas, Liau, Brian B, Xiong, Yan, Jin, Jian, Newton-Bishop, Julia, Zon, Leonard I, Bernstein, Bradley E, Fisher, David E

“…Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic…”
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Chromatin complex dependencies reveal targeting opportunities in leukemia by Najm, Fadi J., DeWeirdt, Peter, Moore, Molly M., Bevill, Samantha M., El Farran, Chadi A., Macias, Kevin A., Hegde, Mudra, Waterbury, Amanda L., Liau, Brian B., van Galen, Peter, Doench, John G., Bernstein, Bradley E.

“…Chromatin regulators are frequently mutated in human cancer and are attractive drug targets. They include diverse proteins that share functional domains and…”
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Total Syntheses of HMP-Y1, Hibarimicinone, and HMP-P1 by Liau, Brian B, Milgram, Benjamin C, Shair, Matthew D

“…Total syntheses of HMP-Y1, atrop-HMP-Y1, hibarimicinone, atrop-hibarimicinone, and HMP-P1 are described using a two-directional synthesis strategy. A novel…”
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RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation by Xie, Qi, Wu, Qiulian, Kim, Leo, Miller, Tyler E, Liau, Brian B, Mack, Stephen C, Yang, Kailin, Factor, Daniel C, Fang, Xiaoguang, Huang, Zhi, Zhou, Wenchao, Alazem, Kareem, Wang, Xiuxing, Bernstein, Bradley E, Bao, Shideng, Rich, Jeremy N

“…Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor-initiating cells (BTICs), also known as cancer stem cells. NOTCH signaling has been…”
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Shotgun Glycomics Identifies Tumor-Associated Glycan Ligands Bound by an Ovarian Carcinoma-Specific Monoclonal Antibody by Liau, B., Tan, B., Teo, G., Zhang, P., Choo, A., Rudd, P. M.

“…Cancers display distinctive carbohydrate molecules (glycans) on their surface proteins and lipids. mAb A4, an in-house generated monoclonal IgM antibody, is…”
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Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery by Ngan, Kevin Chun-Ho, Hoenig, Samuel M, Kwok, Hui Si, Lue, Nicholas Z, Gosavi, Pallavi M, Tanner, David A, Garcia, Emma M, Lee, Ceejay, Liau, Brian B

“…Allostery enables dynamic control of protein function. A paradigmatic example is the tightly orchestrated process of DNA methylation maintenance. Despite the…”
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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML by Vinyard, Michael E., Su, Cindy, Siegenfeld, Allison P., Waterbury, Amanda L., Freedy, Allyson M., Gosavi, Pallavi M., Park, Yongho, Kwan, Eugene E., Senzer, Benjamin D., Doench, John G., Bauer, Daniel E., Pinello, Luca, Liau, Brian B.

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Base editor screens for in situ mutational scanning at scale by Lue, Nicholas Z., Liau, Brian B.

“…A fundamental challenge in biology is understanding the molecular details of protein function. How mutations alter protein activity, regulation, and response…”
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Discovering new biology with drug-resistance alleles by Freedy, Allyson M., Liau, Brian B.

“…Small molecule drugs form the backbone of modern medicine’s therapeutic arsenal. Often less appreciated is the role that small molecules have had in advancing…”
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Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance by Liau, Brian B., Sievers, Cem, Donohue, Laura K., Gillespie, Shawn M., Flavahan, William A., Miller, Tyler E., Venteicher, Andrew S., Hebert, Christine H., Carey, Christopher D., Rodig, Scott J., Shareef, Sarah J., Najm, Fadi J., van Galen, Peter, Wakimoto, Hiroaki, Cahill, Daniel P., Rich, Jeremy N., Aster, Jon C., Suvà, Mario L., Patel, Anoop P., Bernstein, Bradley E.

“…Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by stem-like cancer cells refractory to existing therapies. Understanding the…”
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Base editor scanning charts the DNMT3A activity landscape by Lue, Nicholas Z., Garcia, Emma M., Ngan, Kevin C., Lee, Ceejay, Doench, John G., Liau, Brian B.

“…DNA methylation is critical for regulating gene expression, necessitating its accurate placement by enzymes such as the DNA methyltransferase DNMT3A…”
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Amniotic membrane graft for primary pterygium: comparison with conjunctival autograft and topical mitomycin C treatment by Ma, David Hui-Kang, See, Lai-Chu, Liau, Su-Bin, Tsai, Ray Jui-Fang

“…AIM To study the efficacy and safety of amniotic membrane graft as an adjunctive therapy after removal of primary pterygium, and to compare the clinical…”
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Computing Optimal Max-Min Fair Resource Allocation for Elastic Flows by Nace, D., Doan, N.-L., Gourdin, E., Liau, B.

“…In this paper, we consider the max-min fair resource allocation problem as applied to elastic flows. We are interested in computing the optimal max-min fair…”
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Uncovering the Cellular Target of Agelastatin A by Park, Yongho, Liau, Brian B

“…McClary et al. (2017) identify the eukaryotic ribosome as a cellular target of agelastatin A, resolving the long-standing mystery surrounding the cytotoxic…”
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Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma by Kwok, Hui Si, Freedy, Allyson M., Siegenfeld, Allison P., Morriss, Julia W., Waterbury, Amanda L., Kissler, Stephen M., Liau, Brian B.

“…Drug addiction, a phenomenon where cancer cells paradoxically depend on continuous drug treatment for survival, has uncovered cell signaling mechanisms and…”
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