Search Results - "Liashkovich, Ivan"

A two-phase response of endothelial cells to hydrostatic pressure by Prystopiuk, Valeria, Fels, Benedikt, Simon, Caroline Sophie, Liashkovich, Ivan, Pasrednik, Dzmitry, Kronlage, Cornelius, Wedlich-Söldner, Roland, Oberleithner, Hans, Fels, Johannes

“…The vascular endothelium is exposed to three types of mechanical forces: blood flow-mediated shear stress, vessel diameter-dependent wall tension and…”
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Membrane assembly of Shiga toxin glycosphingolipid receptors and toxin refractiveness of MDCK II epithelial cells by Legros, Nadine, Pohlentz, Gottfried, Steil, Daniel, Kouzel, Ivan U., Liashkovich, Ivan, Mellmann, Alexander, Karch, Helge, Müthing, Johannes

“…Shiga toxins (Stxs) are the major virulence factors of Stx-producing Escherichia coli (STEC), which cause hemorrhagic colitis and severe extraintestinal…”
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RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells by Kouzel, Ivan U., Kehl, Alexander, Berger, Petya, Liashkovich, Ivan, Steil, Daniel, Makalowski, Wojciech, Suzuki, Yutaka, Pohlentz, Gottfried, Karch, Helge, Mellmann, Alexander, Müthing, Johannes

“…The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal…”
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Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes by Bestembayeva, Aizhan, Kramer, Armin, Labokha, Aksana A., Osmanović, Dino, Liashkovich, Ivan, Orlova, Elena V., Ford, Ian J., Charras, Guillaume, Fassati, Ariberto, Hoogenboom, Bart W.

“…Stiffness topography with sharp atomic force microscopy tips can be used to generate nanoscale cross-sections of nuclear pore complexes, and suggests that the…”
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Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier by Liashkovich, Ivan, Pasrednik, Dzmitry, Prystopiuk, Valeria, Rosso, Gonzalo, Oberleithner, Hans, Shahin, Victor

“…Existence of a selective nucleocytoplasmic permeability barrier is attributed to Phenylalanine-Glycine rich proteins (FG-nups) within the central channel of…”
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Membrane potential depolarization decreases the stiffness of vascular endothelial cells by Callies, Chiara, Fels, Johannes, Liashkovich, Ivan, Kliche, Katrin, Jeggle, Pia, Kusche-Vihrog, Kristina, Oberleithner, Hans

“…The stiffness of vascular endothelial cells is crucial to mechanically withstand blood flow and, at the same time, to control deformation-dependent nitric…”
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The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease by Peischard, Stefan, Ho, Huyen Tran, Piccini, Ilaria, Strutz-Seebohm, Nathalie, Röpke, Albrecht, Liashkovich, Ivan, Gosain, Hiteshika, Rieger, Bettina, Klingel, Karin, Eggers, Britta, Marcus, Katrin, Linke, Wolfgang A., Müller, Frank Ulrich, Ludwig, Stephan, Greber, Boris, Busch, Karin, Seebohm, Guiscard

“…A detailed description of pathophysiological effects that viruses exert on their host is still challenging. For the first time, we report a highly controllable…”
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Nano-scale Biophysical and Structural Investigations on Intact and Neuropathic Nerve Fibers by Simultaneous Combination of Atomic Force and Confocal Microscopy by Rosso, Gonzalo, Liashkovich, Ivan, Young, Peter, Shahin, Victor

“…The links between neuropathies of the peripheral nervous system (PNS), including Charcot-Marie-Tooth1A and hereditary neuropathy with liability to pressure…”
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MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells by Keurhorst, Dennis, Liashkovich, Ivan, Frontzek, Fabian, Nitzlaff, Svenja, Hofschröer, Verena, Dreier, Rita, Stock, Christian

“…Both cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane pH, the Na /H…”
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Impact of the Nuclear Envelope on Malignant Transformation, Motility, and Survival of Lung Cancer Cells by Stefanello, Sílvio Terra, Luchtefeld, Isabelle, Liashkovich, Ivan, Pethö, Zoltan, Azzam, Ihab, Bulk, Etmar, Rosso, Gonzalo, Döhlinger, Lilly, Hesse, Bettina, Oeckinghaus, Andrea, Shahin, Victor

“…Nuclear pore complexes (NPCs) selectively mediate all nucleocytoplasmic transport and engage in fundamental cell‐physiological processes. It is hypothesized…”
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Nuclear Envelope Permeability Barrier as a Fast‐Response Intracellular Mechanostat by Shahin, Victor, Kouzel, Ivan U., Rosso, Gonzalo, Liashkovich, Ivan

“…The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli…”
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Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases by Liashkovich, Ivan, Stefanello, Sílvio Terra, Vidyadharan, Reshma, Haufe, Günter, Erofeev, Alexander, Gorelkin, Peter V., Kolmogorov, Vasilii, Mizdal, Caren Rigon, Dulebo, Alexander, Bulk, Etmar, Kouzel, Ian U., Shahin, Victor

“…Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a…”
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Facilitating plasmid nuclear delivery by interfering with the selective nuclear pore barrier by Azzam, Ihab, Liashkovich, Ivan, Luchtefeld, Isabelle, Kouzel, Ivan U., Shahin, Victor

“…Nuclear pore complexes (NPCs) are sophisticated transporters assembled from diverse proteins termed nucleoporins (Nups). They control all nucleocytoplasmic…”
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Nuclear delivery mechanism of herpes simplex virus type 1 genome by Liashkovich, Ivan, Hafezi, Wali, Kühn, Joachim M, Oberleithner, Hans, Shahin, Victor

“…Herpes simplex virus type 1 (HSV‐1) is a widespread human pathogen infecting more than 80% of the population worldwide. Its replication involves an essential,…”
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Caspase-9-dependent decrease of nuclear pore channel hydrophobicity is accompanied by nuclear envelope leakiness by Kramer, Armin, PhD, Liashkovich, Ivan, PhD, Oberleithner, Hans, PhD, Shahin, Victor, PhD

“…Abstract Advances in nanomedicine require conceptual understanding of physiological processes. Apoptosis is a fundamental physiological process that is…”
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Functional implication of the common evolutionary origin of nuclear pore complex and endomembrane management systems by Liashkovich, Ivan, Shahin, Victor

“…Nuclear pore complexes (NPCs) are the sole gateway between the cytoplasm and the nucleus serving both as stringent permeability barrier and active transporters…”
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Nanomechanics of vascular endothelium by Fels, Johannes, Jeggle, Pia, Liashkovich, Ivan, Peters, Wladimir, Oberleithner, Hans

“…The mechanical characteristics of endothelial cells reveal four distinct compartments, namely glycocalyx, cell cortex, cytoplasm and nucleus. There is…”
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In Situ Investigation of Interrelationships Between Morphology and Biomechanics of Endothelial and Glial Cells and their Nuclei by Rosso, Gonzalo, Liashkovich, Ivan, Shahin, Victor

“…Morphology and biomechanics of cells and nuclei are interlinked with one another and play key roles in fundamental physiological processes. While powerful…”
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Schwann cells and neurite outgrowth from embryonic dorsal root ganglions are highly mechanosensitive by Rosso, Gonzalo, Liashkovich, Ivan, Young, Peter, Röhr, Dominik, Shahin, Victor

“…Abstract Biochemical interactions between Schwann cells (SCs) and their substrate are crucial for the peripheral nervous systems (PNS). They are among the…”
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Atomic Force Microscopy for Structural and Biophysical Investigations on Nuclear Pore Complexes by Liashkovich, Ivan, Rosso, Gonzalo, Shahin, Victor

“…Atomic force microscopy (AFM) enables simultaneous generation of topographical and biophysical maps of surfaces of biological samples at nanoresolution in…”
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