Search Results - "Liao, You"
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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output
Published in Cell (01-10-2020)“…Mitochondria, which play central roles in immunometabolic diseases, have their own genome. However, the functions of mitochondria-located noncoding RNAs are…”
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miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program
Published in Nature communications (05-10-2015)“…Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key…”
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Fetal bovine serum albumin inhibits antimicrobial peptide activity and binds drug only in complex with α1-antitrypsin
Published in Scientific reports (14-01-2021)“…Several antimicrobial peptides (AMPs) have been developed for the treatment of infections caused by antibiotic-resistant microbes, but their applications are…”
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The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice
Published in PLoS genetics (22-05-2019)“…N6-Methyladenosine (m6A) RNA methylation plays important roles during development in different species. However, knowledge of m6A RNA methylation in monocots…”
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Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching
Published in Nature biotechnology (01-09-2013)“…Overexpression of a microRNA in rice increases yield, suggesting new routes to crop improvement. Increasing grain yields is a major focus of crop breeders…”
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Red blood cell distribution width: A severity indicator in patients with COVID‐19
Published in Journal of medical virology (01-05-2022)“…Red blood cell distribution width (RDW) was frequently assessed in COVID‐19 infection and reported to be associated with adverse outcomes. However, there was…”
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Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
Published in Nature communications (16-01-2023)“…Emerging evidence shows that the biomechanical environment is required to support cancer stem cells (CSCs), which play a crucial role in drug resistance…”
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8
Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination
Published in Cell research (01-05-2014)“…DNA double-strand breaks (DSBs) are highly cytotoxic lesions and pose a major threat to genome stability if not properly repaired. We and others have…”
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Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
Published in Scientific reports (01-04-2021)“…Acinetobacter baumannii -induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates. Antimicrobial peptides…”
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10
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis
Published in Nature medicine (01-12-2008)“…Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening adverse drug reactions characterized by massive epidermal necrosis, in…”
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LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network
Published in Theranostics (01-01-2020)“…The forkhead box A1 (FOXA1) is a crucial transcription factor in initiation and development of breast, lung and prostate cancer. Previous studies about the…”
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12
DDoS-MSCT: A DDoS Attack Detection Method Based on Multiscale Convolution and Transformer
Published in IET information security (17-09-2024)“…Distributed denial-of-service (DDoS) attacks pose a significant threat to network security due to their widespread impact and detrimental consequences…”
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Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease
Published in Human molecular genetics (15-09-2013)“…5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine. While the dynamics of 5-hmC during neurodevelopment have recently been…”
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Genome-wide screening and functional analysis identify a large number of long noncoding RNAs involved in the sexual reproduction of rice
Published in Genome biology (03-12-2014)“…Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes in mammals and plants. However, the systematic examination of…”
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Self-cooling water disinfection reactor with ultraviolet-C light-emitting diodes
Published in Environmental technology (02-10-2023)“…The use of ultraviolet-C (UV-C) light-emitting diodes (LEDs) as a water sterilization light source poses a serious challenge in heat dissipation. High junction…”
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RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity
Published in Biomaterials (01-03-2024)“…The field of RNA therapeutics has been emerging as the third milestone in pharmaceutical drug development. RNA nanoparticles have displayed motile and…”
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The lipid components of high-density lipoproteins (HDL) are essential for the binding and transportation of antimicrobial peptides in human serum
Published in Scientific reports (16-02-2022)“…Antimicrobial peptides (AMPs) have been developed for the treatment of bacterial infections, but their applications are limited to topical infections since…”
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The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration
Published in Cancers (11-12-2019)“…Cigarette smoking is associated with an increased risk of melanoma metastasis. Smokers show higher PD-L1 expression and better responses to PD-1/PD-L1…”
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Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers
Published in PloS one (14-05-2010)“…MicroRNAs (miRNAs) are approximately 22-nt small non-coding regulatory RNAs that have generally been considered to regulate gene expression at the…”
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Defect structure, ferroelectricity and piezoelectricity in Fe/Mn/Cu-doped K0.5Na0.5NbO3 lead-free piezoelectric ceramics
Published in Journal of the European Ceramic Society (01-12-2018)“…For perovskite Pb-based ceramics, outstanding hardening piezoelectric properties can be easily induced by acceptor dopings of Fe, Mn or Cu, but in this work,…”
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