Search Results - "Liao, Yilie"
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1
Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance
Published in Cell metabolism (06-10-2020)“…The surge in fructose consumption is a major factor behind the rapid rise of nonalcoholic fatty liver disease in modern society. Through flux and genetic…”
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2
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy
Published in EMBO molecular medicine (07-12-2023)“…Loss of pancreatic beta cells is the central feature of all forms of diabetes. Current therapies fail to halt the declined beta cell mass. Thus, strategies to…”
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3
Polyethylene microplastics impede the innate immune response by disrupting the extracellular matrix and signaling transduction
Published in iScience (18-08-2023)“…Microplastics (MPs) can accumulate in animal organs. Numerous studies have linked MPs with immune system. However, the impact of MPs on immune response remains…”
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4
Co‐regulation of hepatic steatosis by ferritinophagy and unsaturated fatty acid supply
Published in Hepatology communications (01-10-2022)“…Both iron overload and iron deficiency have been reported in obesity and metabolic syndromes. Due to the presence of multiple intracellular iron pools and the…”
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5
Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity
Published in Cell reports (Cambridge) (11-02-2020)“…Nutrients stimulate the anabolic synthesis of proteins and lipids, but selective insulin resistance in obesity biases the anabolic program toward lipogenesis…”
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6
Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling
Published in International journal of molecular sciences (24-05-2023)“…Through a comprehensive analysis of the gene expression and dependency in HCC patients and cell lines, LAT1 was identified as the top amino acid transporter…”
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7
Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation
Published in Cell reports (Cambridge) (07-09-2021)“…The principles guiding the diurnal organization of biological pathways remain to be fully elucidated. Here, we perturb the hepatic transcriptome through…”
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The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging
Published in Aging cell (15-10-2024)“…Aging is usually accompanied by excessive body fat gain, leading to increased susceptibility to comorbidities. This study aimed to explore an unexpected…”
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Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency
Published in Aging and disease (01-08-2024)“…Despite decades of research being conducted to understand what physiological deficits in the brain are an underlying basis of psychiatric diseases like…”
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10
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Published in Nature chemical biology (14-11-2024)“…The post-translational modification of intracellular proteins through O-linked β-N-acetylglucosamine (O-GlcNAc) is a conserved regulatory mechanism in…”
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11
Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis
Published in Hepatology (Baltimore, Md.) (01-12-2023)“…SLC25A47 was initially identified as a mitochondrial HCC-downregulated carrier protein, but its physiological functions and transport substrates are unknown…”
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12
Global determination of reaction rates and lipid turnover kinetics in Mus musculus
Published in Cell metabolism (04-04-2023)“…Metabolism is fundamental to life, but measuring metabolic reaction rates remains challenging. Here, we applied C13 fluxomics to monitor the metabolism of…”
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13
Oncogenic lncRNA LINC00973 promotes Warburg effect by enhancing LDHA enzyme activity
Published in Science bulletin (Beijing) (15-07-2021)“…Through a large-scale functional screening, we identified a long non-coding RNA LINC00973 that is highly expressed in many types of human cancers and can…”
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