Search Results - "Liao, Warren S"

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells by Lu, Zhen, Luo, Robert Z, Lu, Yiling, Zhang, Xuhui, Yu, Qinghua, Khare, Shilpi, Kondo, Seiji, Kondo, Yasuko, Yu, Yinhua, Mills, Gordon B, Liao, Warren S-L, Bast, Jr, Robert C

“…The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce autophagy and regulate its outcome in human cancers are poorly understood…”
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Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy by Chen, Min‐Yu, Liao, Warren S.‐L., Lu, Zhen, Bornmann, William G., Hennessey, Violeta, Washington, Michele N., Rosner, Gary L., Yu, Yinhua, Ahmed, Ahmed Ashour, Bast, Robert C.

“…BACKGROUND: Epigenetic therapy has had a significant impact on the management of hematologic malignancies, but its role in the treatment of ovarian cancer…”
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Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 by Mandal, Pijus K, Gao, Fengqin, Lu, Zhen, Ren, Zhiyong, Ramesh, Rajagopal, Birtwistle, J. Sanderson, Kaluarachchi, Kumaralal K, Chen, Xiaomin, Bast, Robert C, Liao, Warren S, McMurray, John S

“…Signal transducer and activator of transcription 3 (Stat3), a target for anticancer drug design, is activated by recruitment to phosphotyrosine residues on…”
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Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3 by Mandal, Pijus K, Liao, Warren S.-L, McMurray, John S

“…The synthesis of prodrugs targeted to the SH2 domain of Stat3 is reported. Using a convergent strategy, the pivaloyloxymethyl phosphonodiester of…”
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Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer by Feng, Weiwei, Lu, Zhen, Luo, Robert Z., Zhang, Xiaohong, Seto, Edward, Liao, Warren S.‐L., Yu, Yinhua

“…ARHI is a maternally imprinted tumor suppressor gene that is expressed in normal breast and ovarian epithelial cells but not in most breast and ovarian…”
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Homocysteine Inhibits Arterial Endothelial Cell Growth Through Transcriptional Downregulation of Fibroblast Growth Factor-2 Involving G Protein and DNA Methylation by Chang, Po-Yuan, Lu, Shao-Chun, Lee, Chii-Ming, Chen, Yi-Jie, Dugan, Tracey A, Huang, Wen-Huei, Chang, Shwu-Fen, Liao, Warren S.L, Chen, Chu-Huang, Lee, Yuan-Teh

“…Homocysteine (Hcy) contributes to atherogenesis and angiostasis by altering the phenotype of arterial endothelial cells (ECs). The present study was aimed at…”
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Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells by Shackleford, Terry J, Zhang, Qingxiu, Tian, Ling, Vu, Thuy T, Korapati, Anita L, Baumgartner, Angela M, Le, Xiao-Feng, Liao, Warren S, Claret, Francois X

“…The c-Jun coactivator, Jun activation-domain binding protein 1 (Jab1) also known as the fifth component of the COP9 signalosome complex (CSN5), is a novel…”
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MEKK3 expression correlates with nuclear factor κ B activity and with expression of antiapoptotic genes in serous ovarian carcinoma by Samanta, Ajoy K., Huang, Helen J., Le, Xiao‐Feng, Mao, Weiqun, Lu, Karen H., Bast, Robert C., Liao, Warren S.‐L.

“…BACKGROUND: Constitutively activated nuclear factor κ B (NFκB) contributes to the development of cancer by regulating the expression of genes involved in cell…”
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Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3) by Mandal, Pijus K., Ren, Zhiyong, Chen, Xiaomin, Kaluarachchi, Kumar, Liao, Warren S.-L., McMurray, John S.

“…Signal transducer and activator of transcription 3 (Stat3) transmits signals from growth factors and interleukin-6 family cytokines by binding to their…”
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Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation by Lu, Jonathan, Jiang, Wei, Yang, Jun-Hai, Chang, Po-Yuan, Walterscheid, Jeffrey P, Chen, Hsin-Hung, Marcelli, Marco, Tang, Daming, Lee, Yuan-Teh, Liao, Warren S L, Yang, Chao-Yuh, Chen, Chu-Huang

“…Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation Jonathan Lu 1 , Wei…”
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ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins by Huang, Shaoyi, Chang, In Soon, Lin, Wenbo, Ye, Wenduo, Luo, Robert Z, Lu, Zhen, Lu, Yiling, Zhang, Ke, Liao, Warren S-L, Tao, Tao, Bast, Jr, Robert C, Chen, Xiaomin, Yu, Yinhua

“…ARHI (aplasia Ras homologue member I; also known as DIRAS3) is an imprinted tumour suppressor gene, the expression of which is lost in the majority of breast…”
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A ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells by NISHIMOTO, Arata, YINHUA YU, LUO, Robert Z, ZHEN LU, XIANG MAO, ZHIYONG REN, WATOWICH, Stephanie S, MILLS, Gordon B, LIAO, Warren S.-L, XIAOMIN CHEN, BAST, Robert C

“…A Ras homologue member I (ARHI) is a novel imprinted tumor suppressor gene whose expression is frequently lost in breast and ovarian cancers. This small…”
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Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer by ZHEN LU, LUO, Robert Z, YINHUA YU, BAST, Robert C, HONGQI PENG, ROSEN, Daniel G, NEELY ATKINSON, E, WARNEKE, Carla, MAOSHENG HUANG, NISHMOTO, Arata, JINSONG LIU, LIAR, Warren S-L

“…Purpose: ARHI expression is lost or markedly down-regulated in the majority of ovarian cancers. The mechanism by which ARHI is down-regulated in ovarian…”
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DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells by Lu, Zhen, Baquero, Maria T, Yang, Hailing, Yang, Maojie, Reger, Albert S, Kim, Choel, Levine, Douglas A, Clarke, Charlotte H, Liao, Warren S-L, Bast Jr, Robert C

“…DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at physiological levels inhibits…”
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A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis by Auzenne, Edmond J, Klostergaard, Jim, Mandal, Pijus K, Liao, Warren S, Lu, Zhen, Gao, Fengqin, Bast, Jr, Robert C, Robertson, Fredika M, McMurray, John S

“…Signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a number of human cancers and cancer cell lines. Via its Src homology…”
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ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers by LUO, Robert Z, XIANJUN FANG, MARQUEZ, Rebecca, LIU, Shu-Ying, MILLS, Gordon B, LIAO, Warren S.-L, YINHUA YU, BAST, Robert C

“…Our group recently identified Ras homolog member I (ARHI), a novel maternally imprinted tumor suppressor gene that encodes a 26 kDa GTP-binding protein with…”
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Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain by McMurray, John S, Mandal, Pijus K, Liao, Warren S, Ren, Zhiyong, Chen, Xiaomin

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The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain by McMurray, John S., Mandal, Pijus K., Liao, Warren S., Klostergaard, Jim, Robertson, Fredika M.

“…Herein we review our progress on the development of phosphopeptide-based prodrugs targeting the SH2 domain of STAT3 to prevent recruitment to cytokine and…”
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The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation by Reddy, Shrikanth A.G, Lin, Yu-Feng, Huang, Helen J, Samanta, Ajoy K, Liao, Warren S.-L

“…Interleukin-1 (IL-1) binds to its type I receptors (IL-1R), which in complex with IL-1R accessory protein (IL-1R AcP) induces various intracellular signaling…”
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Transcription Factor AP-2 Functions as a Repressor That Contributes to the Liver-specific Expression of Serum Amyloid A1 Gene by Ren, Yongsheng, Liao, Warren S.-L.

“…We previously identified transcription factor AP-2 as the nuclear factor that interacts with the tissue-specific repressor element in the rat serum amyloid A1…”
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