Search Results - "Liao, Luciano M"

Pred-hERG: A Novel web-Accessible Computational Tool for Predicting Cardiac Toxicity by Braga, Rodolpho C., Alves, Vinicius M., Silva, Meryck F. B., Muratov, Eugene, Fourches, Denis, Lião, Luciano M., Tropsha, Alexander, Andrade, Carolina H.

“…The blockage of the hERG K+ channels is closely associated with lethal cardiac arrhythmia. The notorious ligand promiscuity of this channel earmarked hERG as…”
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Optimization of carboxymethyl chitosan synthesis using response surface methodology and desirability function by Bukzem, Andrea L., Signini, Roberta, dos Santos, Danilo M., Lião, Luciano M., Ascheri, Diego Palmiro R.

“…In this paper, chitosan was reacted with monochloroacetic acid under alkaline conditions to prepare carboxymethyl chitosan. A 23 full-factorial central…”
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In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design by Porto, William F., Irazazabal, Luz, Alves, Eliane S. F., Ribeiro, Suzana M., Matos, Carolina O., Pires, Állan S., Fensterseifer, Isabel C. M., Miranda, Vivian J., Haney, Evan F., Humblot, Vincent, Torres, Marcelo D. T., Hancock, Robert E. W., Liao, Luciano M., Ladram, Ali, Lu, Timothy K., de la Fuente-Nunez, Cesar, Franco, Octavio L.

“…Plants are extensively used in traditional medicine, and several plant antimicrobial peptides have been described as potential alternatives to conventional…”
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Characterization of the Antimicrobial Peptide Penisin, a Class Ia Novel Lantibiotic from Paenibacillus sp. Strain A3 by Baindara, Piyush, Chaudhry, Vasvi, Mittal, Garima, Liao, Luciano M, Matos, Carolina O, Khatri, Neeraj, Franco, Octavio L, Patil, Prabhu B, Korpole, Suresh

“…Attempts to isolate novel antimicrobial peptides from microbial sources have been on the rise recently, despite their low efficacy in therapeutic applications…”
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Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus by Oliveira, Ruberney S., Biscaia, Stellee M.P., Bellan, Daniel L., Viana, Sthefany R.F., Di-Medeiros Leal, Maria Carolina, Vasconcelos, Ana Flora D., Lião, Luciano M., Trindade, Edvaldo S., Carbonero, Elaine R.

“…•A bioactive fucomannogalactan (FMG-Hm) was isolated from H. marmoreus mushroom.•It consists of α-Galp (1→6) main chain, branched at O-2 by α-Fucp and β-Manp…”
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Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties by Silva, Osmar N., Torres, Marcelo D. T., Cao, Jicong, Alves, Elaine S. F., Rodrigues, Leticia V., Resende, Jarbas M., Lião, Luciano M., Porto, William F., Fensterseifer, Isabel C. M., Lu, Timothy K., Franco, Octavio L., de la Fuente-Nunez, Cesar

“…Novel antibiotics are urgently needed to combat multidrug-resistant pathogens. Venoms represent previously untapped sources of novel drugs. Here we repurposed…”
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Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides by Oshiro, Karen G. N., Freitas, Carlos D. P., Rezende, Samilla B., Orozco, Raquel M. Q., Chan, Lai Y., Lawrence, Nicole, Lião, Luciano M., Macedo, Maria L. R., Craik, David J., Cardoso, Marlon H., Franco, Octávio L.

“…Mastoparans are cationic peptides with multifunctional pharmacological properties. Mastoparan‐R1 and mastoparan‐R4 were computationally designed based on…”
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3‐Halochromones Through Oxidative α‐Halogenation of Enaminones and its Photophysical Investigation: Another Case of Photo‐induced Partially Aromatised Intramolecular Charge Transfer? by Neto, José S. S., Coelho, Filipe T., Doerner, Carlos V., Braga, Antonio L., Lião, Luciano M., Coelho, Felipe L.

“…A versatile synthesis strategy for fluorescent 3‐halo‐4H‐chromen‐4‐one derivatives is reported. The method involves the oxidative α‐halogenation of enaminones…”
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Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide by Irazazabal, Luz N., Porto, William F., Fensterseifer, Isabel C.M., Alves, Eliane S.F., Matos, Carolina O., Menezes, Antônio C.S., Felício, Mário R., Gonçalves, Sónia, Santos, Nuno C., Ribeiro, Suzana M., Humblot, Vincent, Lião, Luciano M., Ladram, Ali, Franco, Octavio L.

“…Antimicrobial peptides (AMPs) are promising candidates for the development of future antibiotics. In an attempt to increase the efficacy of therapeutic AMPs,…”
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Electrochemical determination of carbendazim in grapes and their derivatives by an ionic liquid-modified carbon paste electrode by de Macedo, José Fernando, Alves, Anderson A. C., Sant’Anna, Mércia V. S., Cunha, Frederico G. C., Oliveira, Gerlon de A. R., Lião, Luciano M., Sussuchi, Eliana Midori

“…A novel electrochemical sensor containing an ionic liquid carbon paste electrode was synthesized to determine carbendazim in grape samples. The 2-hydroxy…”
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Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria by Fensterseifer, Isabel C.M., Felício, Mário R., Alves, Eliane S.F., Cardoso, Marlon H., Torres, Marcelo D.T., Matos, Carolina O., Silva, Osmar N., Lu, Timothy K., Freire, Maurício V., Neves, Natan C., Gonçalves, Sónia, Lião, Luciano M., Santos, Nuno C., Porto, William F., de la Fuente-Nunez, Cesar, Franco, Octavio L.

“…Infections caused by Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa foremost among them, constitute a major worldwide health problem…”
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A polyalanine peptide derived from polar fish with anti-infectious activities by Cardoso, Marlon H., Ribeiro, Suzana M., Nolasco, Diego O., de la Fuente-Núñez, César, Felício, Mário R., Gonçalves, Sónia, Matos, Carolina O., Liao, Luciano M., Santos, Nuno C., Hancock, Robert E. W., Franco, Octávio L., Migliolo, Ludovico

“…Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising…”
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LQFM289: Electrochemical and Computational Studies of a New Trimetozine Analogue for Anxiety Treatment by Pereira, Jhon K. A, Costa, André G. C, Rodrigues, Edson S. B, Macêdo, Isaac Y. L, Pereira, Marx O. A, Menegatti, Ricardo, de Oliveira, Severino C. B, Guimarães, Freddy, Lião, Luciano M, Sabino, José R, de S. Gil, Eric

“…This study employs electrochemical and Density Functional Theory (DFT) calculation approaches to investigate the potential of a novel analogue of trimetozine…”
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The potential exploitation of the Malay-red apple (Syzygium malaccense) seed as source of a phosphorylated starch by Santos, Giordanna P, Miranda, Bruna M, Di-Medeiros, Maria C B, Almeida, Viviane O, Ferreira, Richard D, Morais, Danilo A B de, Queiroz, Diego L A, Leles, Maria I G, Lião, Luciano M, Fernandes, Kátia F

“…This work presents the characterization of a novel naturally phosphorylated starch extracted from an unconventional and non-utilized source, the seeds of the…”
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Improvement in Solubility-Permeability Interplay of Psoralens from Brosimum gaudichaudii Plant Extract upon Complexation with Hydroxypropyl-β-cyclodextrin by Machado, Rúbia Darc, Silva, Júlio C G, Silva, Luís A D, Oliveira, Gerlon de A R, Lião, Luciano M, Lima, Eliana M, de Morais, Mariana C, da Conceição, Edemilson C, Rezende, Kênnia R

“…Psoralen (PSO) and 5-methoxypsoralen (5-MOP) are widely used drugs in oral photochemotherapy against vitiligo and major bioactive components of root bark…”
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Preclinical pharmacokinetics of a promising antineoplastic prototype piperazine-containing compound (LQFM018) in rats by a new LC-MS/MS bioanalytical method by Rodrigues, Andryne R., Rodrigues, Caroline R., Gomes, Sandro A., Marques, Stefanne M., Naves, Lara M., Pedrino, Gustavo R., de Oliveira-Neto, Jerônimo R., de Carvalho, Flávio S., Cruz, Alessandro, Lião, Luciano M., Menegatti, Ricardo, Carlos da Cunha, Luiz

“…•High throughput and sensitive bioanalytical method for the LQFM018 quantification.•First and reliable determination of main pharmacokinetic LQFM018…”
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Inhibition of Leishmania amazonensis arginase by fucogalactan isolated from Agrocybe aegerita mushroom by Motoshima, Renan Akio, Rosa, Tainara da F., Mendes, Léia da C., Silva, Estefânia Viana da, Viana, Sthefany R.F., Amaral, Bruno Sérgio do, de Souza, Dulce H.F., Lião, Luciano M., Corradi da Silva, Maria de Lourdes, de Sousa, Lorena R.F., Carbonero, Elaine R.

“…•A fucogalactan (FG-Aa) was purified from the medicinal mushroom Agrocybe aegerita.•The fucogalactan was highly branched by non-reducing ends of α-Fucp.•FG-Aa…”
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MECHANOCHEMISTRY APPLIED TO THE SYNTHESIS OF 2-PHENYLIMIDAZO[1,2-α]PYRIDINE AS A TEACHING TOOL FOR GREEN CHEMISTRY by Neto, José, Guimarães, Leonardo Victor, Coelho, Filipe, Lião, Luciano, Coelho, Felipe

“…In the present work, we developed an experimental class for undergraduate students concerning the linear synthesis of 2-phenylimidazo[1,2-α]pyridine through…”
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Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp2)–H Bond Selenylation of Imidazo[2,1‑b]thiazole and Related Structures by Moraes, Cassio A. O., Santos, Rafaely B. C., Cavalcante, Marcos F. O., Guilhermi, Jhefferson S., Ali, Muhammad A., Botteselle, Giancarlo V., Frizon, Tiago E. A., Shah, Muhammad I. A., Lião, Luciano M., Beatriz, Adilson, Saba, Sumbal, Rafique, Jamal

“…Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the synthesis of selenylated imidazo­[2,1-b]­thiazole by using half molar…”
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meso -Tetra-(4-pyridyl)porphyrin/palladium(II) complexes as anticancer agents by Alves, Kamilla M, Honorato, João, Lião, Luciano M, Velozo-Sa, Vivianne S, Guedes, Adriana P M, Dutra, Jocely de L, Ayalla, Alejando P, Ellena, Javier, Batista, Alzir A, Gonçalves, Pablo J

“…This study reports the synthesis, structural characterization and cytotoxic activity of four new palladium/pyridylporphyrin complexes, with the general formula…”
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