Search Results - "Liao, Jason"

Dynamic RMST curves for survival analysis in clinical trials by Liao, Jason J Z, Liu, G Frank, Wu, Wen-Chi

“…The data from immuno-oncology (IO) therapy trials often show delayed effects, cure rate, crossing hazards, or some mixture of these phenomena. Thus, the…”
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A gated group sequential design for seamless Phase II/III trial with subpopulation selection by Miao, Guanhong, Liao, Jason J Z, Yang, Jing, Anderson, Keaven

“…Due to the high cost and high failure rate of Phase III trials where a classical group sequential design (GSD) is usually used, seamless Phase II/III designs…”
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A hybrid design for dose‐finding oncology clinical trials by Liao, Jason J. Z., Zhou, Feng, Zhou, Heng, Petruzzelli, Lilli, Hou, Kevin, Asatiani, Ekaterine

“…Identifying the maximum tolerated dose (MTD) and recommending a Phase II dose for an investigational treatment is crucial in cancer drug development. A…”
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A flexible parametric survival model for fitting time to event data in clinical trials by Liao, Jason J.Z., Liu, Guanghan Frank

“…Time‐to‐event data are common in clinical trials to evaluate survival benefit of a new drug, biological product, or device. The commonly used parametric models…”
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Optical I/O Technology for Tera-Scale Computing by Young, I.A., Mohammed, E., Liao, J.T.S., Kern, A.M., Palermo, S., Block, B.A., Reshotko, M.R., Chang, P.L.D.

“…This paper describes both a near term and a long term optical interconnect solution, the first based on a packaging architecture and the second based on a…”
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Three steps toward dose optimization for oncology dose finding by Liao, Jason J.Z., Asatiani, Ekaterine, Liu, Qingyang, Hou, Kevin

“…Traditional dose selection for oncology registration trials typically employs a one- or two-step single maximum tolerated dose (MTD) approach. However, this…”
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Approximate confidence limit for the reference scaled bioequivalence with a parallel design by Liao, Jason J.Z., Li, Yifang

“…The reference scaled bioequivalence has been proposed with many successful applications for the highly variable products. The statistical properties for the…”
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Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages by Linton, Samuel S, Abraham, Thomas, Liao, Jason, Clawson, Gary A, Butler, Peter J, Fox, Todd, Kester, Mark, Matters, Gail L

“…Pancreatic ductal adenocarcinoma (PDAC) tumor growth is enhanced by tumor-associated macrophages (TAMs), yet the mechanisms by which tumor cells and TAMs…”
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Mixture survival trees for cancer risk classification by Jia, Beilin, Zeng, Donglin, Liao, Jason J. Z., Liu, Guanghan F., Tan, Xianming, Diao, Guoqing, Ibrahim, Joseph G.

“…In oncology studies, it is important to understand and characterize disease heterogeneity among patients so that patients can be classified into different risk…”
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Analysis of time-to-event data using a flexible mixture model under a constraint of proportional hazards by Liu, Guanghan Frank, Liao, Jason J. Z.

“…Cox proportional hazards (PH) model evaluates the effects of interested covariates under PH assumption without specified the baseline hazard. In clinical trial…”
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Inferring latent heterogeneity using many feature variables supervised by survival outcome by Jia, Beilin, Zeng, Donglin, Liao, Jason J. Z., Liu, Guanghan F., Tan, Xianming, Diao, Guoqing, Ibrahim, Joseph G.

“…In cancer studies, it is important to understand disease heterogeneity among patients so that precision medicine can particularly target high‐risk patients at…”
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Incidental Internal Mammary Lymph Nodes Visualized on Screening Breast MRI by Mack, Meghan, Chetlen, Alison, Liao, Jason

“…The frequency of visualization and size of internal mammary lymph nodes in women undergoing high-risk screening breast MRI is unknown. When these nodes are…”
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Sample size allocation in multiregional equivalence studies by Liao, Jason J.Z., Yu, Ziji, Li, Yulan

“…With the increasing globalization of drug development, the multiregional clinical trial (MRCT) has gained extensive use. The data from MRCTs could be accepted…”
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New insight into Epstein-Barr virus infection using models of stratified epithelium by Hayman, Ian R, Temple, Rachel M, Burgess, Cole K, Ferguson, Mary, Liao, Jason, Meyers, Craig, Sample, Clare E

“…Epstein-Barr virus (EBV) is a ubiquitous human pathogen that is transmitted in saliva. EBV transits through the oral epithelium to infect B cells, where it…”
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Comparability of critical quality attributes for establishing biosimilarity by Liao, Jason J.Z., Darken, Patrick F.

“…To develop a biosimilar product, it is essential to demonstrate the biosimilarity between the proposed biosimilar product and the reference product first in…”
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Using artificial intelligence tools in answering important clinical questions: The KEYNOTE-183 multiple myeloma experience by Liao, Jason J.Z., Farooqui, Mohammed Z.H., Marinello, Patricia, Hartzel, Jonathan, Anderson, Keaven, Ma, Junshui, Gause, Christine K.

“…The phase III, randomized, active-controlled, multicenter, open-label KEYNOTE-183 study (NCT02576977) evaluating pomalidomide and low dose dexamethasone…”
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The effects of reduced nicotine content cigarettes on biomarkers of nicotine and toxicant exposure, smoking behavior and psychiatric symptoms in smokers with mood or anxiety disorders: A double-blind randomized trial by Foulds, Jonathan, Veldheer, Susan, Pachas, Gladys, Hrabovsky, Shari, Hameed, Ahmad, Allen, Sophia I, Cather, Corinne, Azzouz, Nour, Yingst, Jessica, Hammett, Erin, Modesto, Jennifer, Krebs, Nicolle M, Lester, Courtney, Trushin, Neil, Reinhart, Lisa, Wasserman, Emily, Zhu, Junjia, Liao, Jason, Muscat, Joshua E, Richie, Jr, John P, Evins, A Eden

“…The U.S. Food and Drug Administration and the government of New Zealand have proposed a reduction of the nicotine content in cigarettes to very low levels…”
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Ethnic sensitivity analyses of pharmacokinetics, efficacy and safety in polycythemia vera treatment with ropeginterferon alfa-2b by Qin, Albert, Wu, Daoxiang, Liao, Jason, Xie, Shuping, Chen, Haoqi, Gao, Yucheng, Cui, Jie, Su, Xia, Miyachi, Narihisa, Sato, Toshiaki, Li, Yaning, Zhang, Jingjing, Shen, Weihong, Wang, Wei

“…Ropeginterferon alfa-2b (Ropeg) is approved for the treatment of adults with polycythemia vera (PV). This report aims to analyze the ethnic sensitivity of…”
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Design and Implementation of an IoT Acoustic-Controlled Pillow for Sleep Health Monitoring by Liao, Jason K., Lai, Chun Yin, Chan, Chetwyn Che Hin, Mung, Steve W. Y.

“…This letter introduces an Internet of Things (IoT) acoustic-controlled pillow to reduce environmental noise, monitor snoring, and mitigate insomnia symptoms…”
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Details of the Collagen and Elastin Architecture in the Human Limbal Conjunctiva, Tenon's Capsule and Sclera Revealed by Two-Photon Excited Fluorescence Microscopy by Park, Choul Yong, Marando, Catherine M, Liao, Jason A, Lee, Jimmy K, Kwon, Jiwon, Chuck, Roy S

“…To investigate the architecture and distribution of collagen and elastin in human limbal conjunctiva, Tenon's capsule, and sclera. The limbal conjunctiva,…”
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