Search Results - "Liang, Zhongqin"

Resveratrol, a potential radiation sensitizer for glioma stem cells both in vitro and in vivo by Wang, Long, Long, Linmei, Wang, Wenjuan, Liang, Zhongqin

“…Glioblastoma is a malignant human cancer that confers a dismal prognosis. Ionizing radiation (IR) is applied as the standard treatment for malignant gliomas…”
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Curcumin promotes differentiation of glioma‐initiating cells by inducing autophagy by Zhuang, Wenzhuo, Long, Linmei, Zheng, Bingxin, Ji, Wenjun, Yang, Neng, Zhang, Qingqing, Liang, Zhongqin

“…Glioblastoma (GBM) is a highly aggressive brain tumor characterized by increased proliferation and resistance to chemotherapy and radiotherapy. Recently, a…”
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Induction of autophagy promotes differentiation of glioma‐initiating cells and their radiosensitivity by Zhuang, Wenzhuo, Li, Bingzong, Long, Linmei, Chen, Liesong, Huang, Qiang, Liang, Zhongqin

“…Glioblastoma (GBM) is a highly aggressive brain tumor characterized by increased proliferation and resistance to chemotherapy and radiotherapy. Recently, the…”
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The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells by Li, Jun, Qin, Zhenghong, Liang, Zhongqin

“…Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced…”
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Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC by Wang, Wenjuan, Xiong, Yajie, Ding, Xinyuan, Wang, Long, Zhao, Yifan, Fei, Yao, Zhu, Ying, Shen, Xiao, Tan, Caihong, Liang, Zhongqin

“…Ionizing radiation (IR) is one of the major clinical therapies of cancer, although it increases the epithelial-mesenchymal transition (EMT) of non-small cell…”
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Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells by TAN, CAIHONG, QIAN, XIAOQIANG, JIA, RONGDI, WU, MIN, LIANG, ZHONGQIN

“…Non-small cell lung carcinoma (NSCLC) is one of the most refractory cancers in the clinic; it is insensitive to chemotherapy and is usually excised. However,…”
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Parkinson's disease involves autophagy and abnormal distribution of cathepsin L by Li, Lingyun, Wang, Xiaoxia, Fei, Xifeng, Xia, Liping, Qin, Zhenghong, Liang, Zhongqin

“…▶ Abnormal distribution of cathepsin L is observed in substantia nigral of patients with Parkinson's disease. ▶ 6-OHDA induces nuclear traslocation of…”
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Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms by Zhao, Yifan, Shen, Xiao, Zhu, Ying, Wang, Anqi, Xiong, Yajie, Wang, Long, Fei, Yao, Wang, Yan, Wang, Wenjuan, Lin, Fang, Liang, Zhongqin

“…Cathepsin L (CTSL) is a cysteine protease known to have important roles in regulating cancer cellular resistance to chemotherapy. However mechanism underlying…”
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NF-κB is involved in the regulation of autophagy in mutant p53 cells in response to ionizing radiation by Zhu, Ying, Zuo, Wenqing, Shen, Xiao, Liu, Yali, Zhao, Yifan, Xiong, Yajie, Cao, Huimin, Wang, Yan, Liang, Zhongqin

“…Chemotherapy and ionizing radiation (IR) can induce autophagy in tumor cells. Here, we report that the level of autophagy in tumor cells was related to the…”
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Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells by Xiang, Bei, Fei, Xifeng, Zhuang, Wenzhuo, Fang, Yun, Qin, Zhenghong, Liang, Zhongqin

“…Abstract Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this…”
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Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3β/CUX1 pathway by Fei, Yao, Xiong, Yajie, Shen, Xiao, Zhao, Yifan, Zhu, Ying, Wang, Long, Liang, Zhongqin

“…Cathepsin L (CTSL) is a lysosomal cysteine protease overexpressed and secreted by tumor cells. Our previous study found that CTSL was involved in ionizing…”
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B-Myb participated in ionizing radiation-induced apoptosis and cell cycle arrest in human glioma cells by Shen, Xiao, Cao, Huimin, Zhu, Ying, Zhao, Yifan, Liu, Yali, Zuo, Wenqing, Lin, Fang, Liang, Zhongqin

“…As a common treatment of human glioma, ionizing radiation (IR) was reported to result in cell cycle arrest. However, the mechanisms underlying IR-induced…”
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Clk1‐regulated aerobic glycolysis is involved in glioma chemoresistance by Zhang, Li, Yang, Huicui, Zhang, Wenbin, Liang, Zhongqin, Huang, Qiang, Xu, Guoqiang, Zhen, Xuechu, Zheng, Long Tai

“…Chemoresistance remains a major challenge for the treatment of glioma. In this study, we investigated the role of Clock 1 (Clk1), which encodes an enzyme that…”
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Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro by Wang, Wenjuan, Long, Linmei, Wang, Long, Tan, Caihong, Fei, Xifeng, Chen, Leisong, Huang, Qiang, Liang, Zhongqin

“…Highlights • Expressions of Cathepsin L and CD133 were correlated with human glioma malignancy. • Knockdown of Cathepsin L leads to radiosensitization in GSCs…”
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Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells by Fei, Yao, Xiong, Yajie, Zhao, Yifan, Wang, Wenjuan, Han, Meilin, Wang, Long, Tan, Caihong, Liang, Zhongqin

“…Abstract Curcumin can be used to prevent and treat cancer. However, its exact underlying molecular mechanisms remain poorly understood. Cathepsin L, a…”
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Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-β-mediated epithelial-mesenchymal transition by ZHANG, QINGQING, HAN, MEILING, WANG, WENJUAN, SONG, YUNZHEN, CHEN, GANG, WANG, ZHONG, LIANG, ZHONGQIN

“…Cathepsin L, a lysosomal acid cysteine protease, was found to be overexpressed in several types of human carcinomas. However, its functional roles in tumor…”
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K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway by Wang, Long, Zhao, Yifan, Xiong, Yajie, Wang, Wenjuan, Fei, Yao, Tan, Caihong, Liang, Zhongqin

“…K-ras mutation is involved in cancer progression including invasion and migration, but the underlying mechanism is not yet clear. Cathepsin L is a lysosomal…”
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Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH-SY5Y cells exposed to 6-hydroxydopamine by Li, Lingyun, Gao, Luyan, Song, Yunzhen, Qin, Zheng-Hong, Liang, Zhongqin

“…Autophagy and apoptosis are common responses to pathological damage in the process of Parkinson's disease (PD), and lysosome dysfunction may contribute to the…”
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Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells by Xiong, Yajie, Ji, Wenjun, Fei, Yao, Zhao, Yifan, Wang, Long, Wang, Wenjuan, Han, Meilin, Tan, Caihong, Fei, Xifeng, Huang, Qiang, Liang, Zhongqin

“…An important therapeutic method of glioblastoma, the most common primary brain tumor, is radiotherapy. However, several studies reported recently that…”
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The role of autophagy in sensitizing malignant glioma cells to radiation therapy by Zhuang, Wenzhuo, Qin, Zhenghong, Liang, Zhongqin

“…Malignant gliomas represent the majority of primary brain tumors. The current standard treatments for malignant gliomas include surgical resection, radiation…”
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