Search Results - "Liang, Yaxuan"

Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb by Mathiyalagan, Prabhu, Liang, Yaxuan, Kim, David, Misener, Sol, Thorne, Tina, Kamide, Christine E, Klyachko, Ekaterina, Losordo, Douglas W, Hajjar, Roger J, Sahoo, Susmita

“…RATIONALE:Paracrine secretions seem to mediate therapeutic effects of human CD34 stem cells locally transplanted in patients with myocardial and critical limb…”
Get full text

New Therapeutics for Extracellular Vesicles: Delivering CRISPR for Cancer Treatment by Yan, Biying, Liang, Yaxuan

“…Cancers are defined by genetic defects, which underlines the prospect of using gene therapy in patient care. During the past decade, CRISPR technology has…”
Get full text

Experimental, Systems, and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell–Derived Exosomes From Pediatric Patients by Agarwal, Udit, George, Alex, Bhutani, Srishti, Ghosh-Choudhary, Shohini, Maxwell, Joshua T, Brown, Milton E, Mehta, Yash, Platt, Manu O, Liang, Yaxuan, Sahoo, Susmita, Davis, Michael E

“…RATIONALE:Studies have demonstrated that exosomes can repair cardiac tissue post–myocardial infarction and recapitulate the benefits of cellular therapy…”
Get full text

Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy by Liang, Yaxuan, Lehrich, Brandon M., Zheng, Siyang, Lu, Mengrou

“…Extracellular vesicles (EVs) are released by many cell types and distributed within various biofluids. EVs have a lipid membrane‐confined structure that allows…”
Get full text

Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media by Lehrich, Brandon M, Liang, Yaxuan, Khosravi, Pooya, Federoff, Howard J, Fiandaca, Massimo S

“…It is known that culture media (CM) promotes cellular growth, adhesion, and protects explanted primary brain cells from in vitro stresses. The fetal bovine…”
Get full text

Exosomes Explosion for Cardiac Resuscitation by Liang, Yaxuan, PhD, Sahoo, Susmita, PhD

“…Collectively, cell therapy approaches have been shown over the last decade, to augment cardiac function by multiple means, such as reducing fibrosis,…”
Get full text

miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy by Oh, Jae Gyun, Watanabe, Shin, Lee, Ahyoung, Gorski, Przemek A, Lee, Philyoung, Jeong, Dongtak, Liang, Lifan, Liang, Yaxuan, Baccarini, Alessia, Sahoo, Susmita, Brown, Brian D, Hajjar, Roger J, Kho, Changwon

“…RATIONALE:Abnormal SUMOylation has emerged as a characteristic of heart failure (HF) pathology. Previously, we found reduced SUMO1 (small ubiquitin-like…”
Get full text

Complex N-Linked Glycans Serve as a Determinant for Exosome/Microvesicle Cargo Recruitment by Liang, Yaxuan, Eng, William S., Colquhoun, David R., Dinglasan, Rhoel R., Graham, David R., Mahal, Lara K.

“…Exosomes, also known as microvesicles (EMVs), are nano-sized membranous particles secreted from nearly all mammalian cell types. These nanoparticles play…”
Get full text

Foetal bovine serum influence on in vitro extracellular vesicle analyses by Lehrich, Brandon M., Liang, Yaxuan, Fiandaca, Massimo S.

“…Currently, there exist vastly heterogeneous cell culture conditions for EV production and isolation (Consortium, 2017). [...]there is a current need to define…”
Get full text

AAV-Containing Exosomes as a Novel Vector for Improved Gene Delivery to Lung Cancer Cells by Liu, Bin, Li, Zhiqing, Huang, Shi, Yan, Biying, He, Shan, Chen, Fengyuan, Liang, Yaxuan

“…Lung carcinoma is the most common type of cancer and the leading cause of cancer-related death worldwide. Among the numerous therapeutic strategies for the…”
Get full text

Competition between FLS and DFR regulates the distribution of flavonols and proanthocyanidins in Rubus chingii Hu by Lei, Ting, Huang, Jun, Ruan, Haixiang, Qian, Wei, Fang, Zhou, Gu, Chunyang, Zhang, Niuniu, Liang, Yaxuan, Wang, Ziyun, Gao, Liping, Wang, Yunsheng

“…Hu is a berry plant of the genus of the Rosaceae family, which has high nutritional and medicinal value and is rich in flavonoids. Flavonol synthase (FLS) and…”
Get full text

Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode by Agrawal, Praveen, Kurcon, Tomasz, Pilobello, Kanoelani T., Rakusa, John F., Koppolu, Sujeethraj, Liu, Zhongyin, Batista, Bianca S., Enga, William S., Hsu, Ku-Lung, Liang, Yaxuan, Mahal, Lara K.

“…Cell surface glycans form a critical interface with the biological milieu, informing diverse processes from the inflammatory cascade to cellular migration…”
Get full text

Functional equivalence of stem cell and stem cell‐derived extracellular vesicle transplantation to repair the irradiated brain by Smith, Sarah M., Giedzinski, Erich, Angulo, Maria C., Lui, Tiffany, Lu, Celine, Park, Audrey L., Tang, Sharon, Martirosian, Vahan, Ru, Ning, Chmielewski, Nicole N., Liang, Yaxuan, Baulch, Janet E., Acharya, Munjal M., Limoli, Charles L.

“…Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive…”
Get full text

Response to "Technical approaches to reduce interference of Fetal calf serum derived RNA in the analysis of extracellular vesicle RNA from cultured cells" by Lehrich, Brandon M., Liang, Yaxuan, Fiandaca, Massimo S.

“…[...]these contaminant EVs not only influence the ability to characterize the EVs isolated from conditioned in vitro culture media but also may affect the…”
Get full text

FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair by Mathiyalagan, Prabhu, Adamiak, Marta, Mayourian, Joshua, Sassi, Yassine, Liang, Yaxuan, Agarwal, Neha, Jha, Divya, Zhang, Shihong, Kohlbrenner, Erik, Chepurko, Elena, Chen, Jiqiu, Trivieri, Maria G, Singh, Rajvir, Bouchareb, Rihab, Fish, Kenneth, Ishikawa, Kiyotake, Lebeche, Djamel, Hajjar, Roger J, Sahoo, Susmita

“…BACKGROUND:Despite its functional importance in various fundamental bioprocesses, studies of N-methyladenosine (m6A) in the heart are lacking. Here, we show…”
Get full text

Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart by Li, Xisheng, La Salvia, Sabrina, Liang, Yaxuan, Adamiak, Marta, Kohlbrenner, Erik, Jeong, Dongtak, Chepurko, Elena, Ceholski, Delaine, Lopez-Gordo, Estrella, Yoon, Seonghun, Mathiyalagan, Prabhu, Agarwal, Neha, Jha, Divya, Lodha, Shweta, Daaboul, George, Phan, Anh, Raisinghani, Nikhil, Zhang, Shihong, Zangi, Lior, Gonzalez-Kozlova, Edgar, Dubois, Nicole, Dogra, Navneet, Hajjar, Roger J, Sahoo, Susmita

“…Adeno-associated virus (AAV) has emerged as one of the best tools for cardiac gene delivery due to its cardiotropism, long-term expression, and safety…”
Get full text

Machine learning combined with multi-source data fusion for rapid quality assessment of yellow rice wine with different aging years by Zhang, Zhi-Tong, Li, Yu, Bai, Lei, Chen, Pan, Jiang, Yue, Qi, Yali, Guan, Huanhuan, Liang, Yaxuan, Yuan, Dongping, Lu, Tulin, Yan, Guojun

“…[Display omitted] •The antioxidant capacities of JRW generally increased with the aging times.•24 main aroma compounds were identified in JRW, of which five…”
Get full text

Abstract 10631: Exosome-Encapsulated Adeno-Associated Viruses as a Novel Cardiotropic Vector for Gene Therapy in Heart Failure by La Salvia, Sabrina, Li, Xisheng, Liang, Yaxuan, Adamiak, Marta, Parikh, Mihir, Okoli, Kimberly, Gonzalez-Kozlova, Edgar, Dogra, Navneet, Dubois, Nicole C, Hajjar, Roger J, Sahoo, Susmita

“…Adeno-associated viruses (AAVs) are the vectors of choice for long-term delivery of genes to the heart and due to their safety in clinics. Despite its many…”
Get full text

Abstract 12178: Extracellular Vesicle-Encapsulated AAVs for Therapeutic Gene Delivery to the Heart by La Salvia, Sabrina, Li, Xisheng, Liang, Yaxuan, Adamiak, Marta, Kohlbrenner, Erik, Lopez-Gordo, Estrella, Phan, Anh, Raisinghani, Nikhil, zhang, shihong, Gonzalez Kozlova, Edgar, Dubois, Nicole, Dogra, Navneet, Hajjar, Roger, Sahoo, Susmita

“…BackgroundAdeno-associated virus (AAV) has emerged as one of the best tools for cardiac gene delivery due to its cardiotropism, long-term expression, and…”
Get full text

Abstract MP165: Exosome-mediated Encapsulation Alters AAV Antigenicity and Infectivity: Implications for Gene Delivery in the Heart by Adamiak, Marta, Liang, Yaxuan, Sherman, Cherrie, Lodha, Shweta, Kohlbrenner, Erik, Jeong, Dongtak, Ceholski, Delaine K, Dogra, Navneet, Dubois, Nicole, Hajjar, Roger J, SAHOO, Susmita

“…Abstract only Gene therapy is a promising approach for the treatment of cardiovascular disease. Current strategies for myocardial gene transfer include the use…”
Get full text