Search Results - "Liang, Tony W."

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index by Desnoyers, Luc R, Vasiljeva, Olga, Richardson, Jennifer H, Yang, Annie, Menendez, Elizabeth E M, Liang, Tony W, Wong, Chihunt, Bessette, Paul H, Kamath, Kathy, Moore, Stephen J, Sagert, Jason G, Hostetter, Daniel R, Han, Fei, Gee, Jason, Flandez, Jeanne, Markham, Kate, Nguyen, Margaret, Krimm, Michael, Wong, Kenneth R, Liu, Shouchun, Daugherty, Patrick S, West, James W, Lowman, Henry B

“…Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing…”
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Development of an Fc-Enhanced Anti―B7-H3 Monoclonal Antibody with Potent Antitumor Activity by LOO, Deryk, ALDERSON, Ralph F, SON, Tom, YAN CHEN, EASTON, Ann N, LI, Jonathan C, RILLEMA, Jill R, LICEA, Monica, FIEGER, Claudia, LIANG, Tony W, MATHER, Jennie P, KOENIG, Scott, CHEN, Francine Z, STEWART, Stanford J, JOHNSON, Syd, BONVINI, Ezio, MOORE, Paul A, LING HUANG, WENJUN ZHANG, GORLATOV, Sergey, BURKE, Steve, CICCARONE, Valentina, HUA LI, YINHUA YANG

“…The goal of this research was to harness a monoclonal antibody (mAb) discovery platform to identify cell-surface antigens highly expressed on cancer and…”
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Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation by Liang, T W, DeMarco, R A, Mrsny, R J, Gurney, A, Gray, A, Hooley, J, Aaron, H L, Huang, A, Klassen, T, Tumas, D B, Fong, S

“…Cell-cell interactions of the mucosal epithelia are important for the maintenance and establishment of epithelial barrier function. During events of…”
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The Coiled-coil Domain of Occludin Can Act to Organize Structural and Functional Elements of the Epithelial Tight Junction by Nusrat, Asma, Chen, Jason A., Foley, Chris S., Liang, Tony W., Tom, Jeffrey, Cromwell, M., Quan, Cliff, Mrsny, Randall J.

“…Occludin is an integral membrane protein that has been suggested to play a role in the organization and dynamic function of the epithelial tight junction (TJ)…”
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Vascular Endothelial-Junctional Adhesion Molecule (VE-JAM)/JAM 2 Interacts with T, NK, and Dendritic Cells Through JAM 3 by Liang, Tony W, Chiu, Henry H, Gurney, Austin, Sidle, Aiko, Tumas, Daniel B, Schow, Peter, Foster, Jessica, Klassen, Toni, Dennis, Kathryn, DeMarco, Richard A, Pham, Thinh, Frantz, Gretchen, Fong, Sherman

“…Screening expressed sequence tag databases for endothelial-specific homologs to human junctional adhesion molecule (JAM) and A33-Ag, we identified a protein of…”
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Neutrophil Transmigration under Shear Flow Conditions In Vitro Is Junctional Adhesion Molecule-C Independent by Sircar, Monica, Bradfield, Paul F, Aurrand-Lions, Michel, Fish, Richard J, Alcaide, Pilar, Yang, Lin, Newton, Gail, Lamont, Deanna, Sehrawat, Seema, Mayadas, Tanya, Liang, Tony W, Parkos, Charles A, Imhof, Beat A, Luscinskas, Francis W

“…Endothelial cell junctional adhesion molecule (JAM)-C has been proposed to regulate neutrophil migration. In the current study, we used function-blocking mAbs…”
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Evidence for cross-reactivity of JAM-C antibodies: implications for cellular localization studies by Betanzos, Abigail, Schnoor, Michael, Severson, Eric A., Liang, Tony W., Parkos, Charles A.

“…Background information. JAM‐C (junctional adhesion molecule C) has been implicated in the regulation of leukocyte migration, cell polarity, spermatogenesis,…”
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CD47 Mediates Post-Adhesive Events Required for Neutrophil Migration across Polarized Intestinal Epithelia by Parkos, Charles A., Colgan, Sean P., Liang, Tony W., Nusrat, Asma, Bacarra, Abraham E., Carnes, Denice K., Madara, James L.

“…Transepithelial migration of neutrophils (PMN) is a defining characteristic of active inflammatory states of mucosal surfaces. The process of PMN…”
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Functional Mapping of CD11b/CD18 Epitopes Important in Neutrophil-Epithelial Interactions: A Central Role of the I Domain by Balsam, Leora B, Liang, Tony W, Parkos, Charles A

“…In the intestine, lung, and urinary tract, neutrophil (polymorphonuclear leukocyte, PMN) transepithelial migration is dependent on the leukocyte beta2 integrin…”
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Abstract 1832: Development of a splicing modulator-based ADC payload class with immune stimulatory properties for cancer therapy by Mitra, Satyajit K., Jammalamadaka, Vasu, Kang, Jeffrey, Losic, Teodora, Tuffy, Greg, Liang, Tony W., Tipton, Kim, Lopez, Adriana, Savage, Scott, Monteith, William, Haskins, William E., Jurica, Melissa S., Satyal, Sanjeev, Do, Mary

“…Background: Thailanstatins are naturally occurring anti-proliferative compounds that target spliceosomes and modulate pre-mRNA splicing. Alterations in…”
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Abstract 4570: Development of a proteolytically activatable EGFR Probody for cancer therapy by Desnoyers, Luc R., Yang, Annie, Liang, Tony W., Moore, Stephen, Sagert, Jason, Hostetter, Daniel R., Menendez, Elizabeth, Han, Fei, Krimm, Michael, Wong, Ken, Richardson, Jennifer, West, Jim W., Liu, Shouchun, Vasiljeva, Olga, Lowman, Henry B.

“…Antibodies directed to specific disease-related antigens have proven to be very successful therapeutics for a variety of disease indications. In spite of their…”
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Glycosylation of CD44v6: Role of Sialyl Lewis a in Late Events During Neutrophil Transepithelial Migration by Brazil, Jennifer Catherine, Kolegraff, Keli N, Lee, Winston Y, Liang, Tony W, Nusrat, Asma, Parkos, Charles A, Louis, Nancy A

“…Transepithelial migration (TEM) of large numbers of neutrophils (PMN) is a histopathological hallmark of many mucosal inflammatory diseases, yet the mechanisms…”
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Cell-Specific Peptide Binding by Human Neutrophils by Mazzucchelli, Luca, Burritt, James B., Jesaitis, Algirdas J., Nusrat, Asma, Liang, Tony W., Gewirtz, Andrew T., Schnell, Frederick J., Parkos, Charles A.

“…Analysis of peptide binding to human neutrophils (PMN) using phage display techniques has revealed cell-specific motifs reactive with the PMN surface. Phage…”
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Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils by Parkos, C A, Colgan, S P, Diamond, M S, Nusrat, A, Liang, T W, Springer, T A, Madara, J L

“…Epithelial dysfunction and patient symptoms in inflammatory intestinal diseases such as ulcerative colitis and Crohn's disease correlate with migration of…”
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Neutrophil transepithelial migration: regulation at the apical epithelial surface by Fc-mediated events by Reaves, T A, Colgan, S P, Selvaraj, P, Pochet, M M, Walsh, S, Nusrat, A, Liang, T W, Madara, J L, Parkos, C A

“…Neutrophil (PMN) transepithelial migration is a major effector of epithelial defense in inflammatory diseases involving mucosal surfaces. However, major…”
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Unmasking of intestinal epithelial lateral membrane β1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv-mediated invasion by Yersinia pseudotuberculosis by MCCORMICK, B. A, NUSRAT, A, PARKOS, C. A, D'ANDREA, L, HOFMAN, P. M, CARNES, D, LIANG, T. W, MADARA, J. L

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Non-serum-dependent chemotactic factors produced by Candida albicans stimulate chemotaxis by binding to the formyl peptide receptor on neutrophils and to an unknown receptor on macrophages by EDENS, H. A, PARKOS, C. A, LIANG, T. W, JESAITIS, A. J, CUTLER, J. E, MIETTINEN, H. M

“…Serum-free culture filtrates of six Candida species and Saccharomyces cerevisiae were found to contain chemoattractants for human polymorphonuclear leukocytes…”
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Non-Serum-Dependent Chemotactic Factors Produced byCandida albicans Stimulate Chemotaxis by Binding to the Formyl Peptide Receptor on Neutrophils and to an Unknown Receptor on Macrophages by Heather A. Edens, Charles A. Parkos, Tony W. Liang, Algirdas J. Jesaitis, Jim E. Cutler, Heini M. Miettinen

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cell-specific peptide binding by human neutrophils by MAZZUCCHELLI, L, BURRITT, J. B, JESAITIS, A. J, NUSRAT, A, LIANG, T. W, GEWIRTZ, A. T, SCHNELL, F. J, PARKOS, C. A

“…Analysis of peptide binding to human neutrophils (PMN) using phage display techniques has revealed cell-specific motifs reactive with the PMN surface. Phage…”
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