Search Results - "Liang, Sidney"

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans by Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

“…Significant work has been dedicated to the discovery of JAK kinase inhibitors resulting in several compounds entering clinical development and two FDA approved…”
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Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors by Casimiro-Garcia, Agustin, Trujillo, John I, Vajdos, Felix, Juba, Brian, Banker, Mary Ellen, Aulabaugh, Ann, Balbo, Paul, Bauman, Jonathan, Chrencik, Jill, Coe, Jotham W, Czerwinski, Robert, Dowty, Martin, Knafels, John D, Kwon, Soojin, Leung, Louis, Liang, Sidney, Robinson, Ralph P, Telliez, Jean-Baptiste, Unwalla, Ray, Yang, Xin, Thorarensen, Atli

“…Ongoing interest in the discovery of selective JAK3 inhibitors led us to design novel covalent inhibitors that engage the JAK3 residue Cys909 by cyanamide, a…”
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Long-Term Refugee Health: Health Behaviors and Outcomes of Cambodian Refugee and Immigrant Women by Nelson-Peterman, Jerusha L., Toof, Robin, Liang, Sidney L., Grigg-Saito, Dorcas C.

“…Refugees in the United States have high rates of chronic disease. Both long-term effects of the refugee experience and adjustment to the U.S. health…”
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Portal vein tumor thrombus from gastric cancer by Liang Ong, Sidney Ching, Batumaly, Santha Kumari, Jusoh, Suryani Md

“…A 53-year-old woman presented with left-sided abdominal pain, nausea and vomiting for the past 3 months with associated loss of appetite and weight. On…”
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Decreases in Smoking Prevalence in Asian Communities Served by the Racial and Ethnic Approaches to Community Health (REACH) Project by YOULIAN LIAO, TSOH, Janice Y, GILES, Wayne H, CHEN, Roxana, FOO, Mary Anne, GARVIN, Cheza C, GRIGG-SAITO, Dorcas, LIANG, Sidney, MCPHEE, Stephen, NGUYEN, Tung T, TRAN, Jacqueline H

“…We examined trends in smoking prevalence from 2002 through 2006 in 4 Asian communities served by the Racial and Ethnic Approaches to Community Health (REACH)…”
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Oxidative C−C Bond-Forming Reaction of Electron-Rich Alkylbenzyl Ether with Trimethylvinyloxysilane by Ying, Bai-Ping, Trogden, Bridget G, Kohlman, Daniel T, Liang, Sidney X, Xu, Yao-Chang

“…Treatment of an electron-rich benzyl ether with DDQ at ambient temperature followed by addition of a silyl enol ether undergoes a C−C bond-forming reaction to…”
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Tertiary Pentyl Groups Enhance Salen Titanium Catalyst for Highly Enantioselective Trimethylsilylcyanation of Aldehydes by Liang, Sidney, Bu, Xiu R

“…tert-Pentyl groups are recognized to be highly effective steric groups that can enhance enantioselectivity of salen titanium complexes when they are used in…”
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PDE-10A inhibitors as insulin secretagogues by Cantin, Louis-David, Magnuson, Steven, Gunn, David, Barucci, Nicole, Breuhaus, Marina, Bullock, William H., Burke, Jennifer, Claus, Thomas H., Daly, Michelle, DeCarr, Lynn, Gore-Willse, Ann, Hoover-Litty, Helana, Kumarasinghe, Ellalahewage S., Li, Yaxin, Liang, Sidney X., Livingston, James N., Lowinger, Timothy, MacDougall, Margit, Ogutu, Herbert O., Olague, Alan, Ott-Morgan, Ronda, Schoenleber, Robert W., Tersteegen, Adrian, Wickens, Philip, Zhang, Zhonghua, Zhu, Jian, Zhu, Lei, Sweet, Laurel J.

“…A series of quinoline-based PDE-10A inhibitors was determined to cause insulin secretion in vitro. Optimized compounds were evaluated in vivo where…”
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Unsymmetric chiral salen Schiff bases: A new chiral ligand pool from bis-schiff bases containing two different salicylaldehyde units by Lopez, Jose, Liang, Sidney, Bu, Xiu R.

“…An efficient and facile synthesis of a new class of novel chiral Salen Schiff base ligands has been developed via a stepwise approach. An important feature of…”
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Self-reported health among Cambodians in Lowell, Massachusetts by Koch-Weser, Susan, Liang, Sidney L, Grigg-Saito, Dorcas C

“…National health data reported for Asians in the aggregate present a picture of good health, but significant health disparities exist between Southeast Asian…”
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Imaging features of toxic megacolon by Ong, Sidney Ching Liang, Mohaidin, Nadiah

“…In earlier reviews, mortality rates vary from 19% to 27% with up to fivefold increase in mortality rate in case of perforation.1 2 In 2018, however, Doshi et…”
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Stereoselective, Oxidative C−C Bond Coupling of Naphthopyran Induced by DDQ:  Stereocontrolled Total Synthesis of Deoxyfrenolicin by Xu, Yao-Chang, Kohlman, Dan T, Liang, Sidney X, Erikkson, Chad

“…A formal total synthesis of pyranonaphthoquinone natural product deoxyfrenolicin 1 is described. The key step in the synthesis involves the use of…”
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Incidental discovery of Amyand's hernia by Mohaidin, Nadiah, Ong, Sidney Ching Liang

“…A 58-year-old woman was referred to Hospital Tuanku Ja’afar (Seremban, Malaysia) for contrast-enhanced CT abdomen and pelvis following discovery of a solid…”
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The readily available tert-pentyl group as a most effective simple directing group for asymmetric synthesis: a case study on Salen–Mn(III)-catalyzed epoxidation by Gaquere, Anne, Liang, Sidney, Hsu, Fu-Lian, Bu, Xiu R

“…The tert-pentyl group has been found to produce a pronounced stereodirecting effect, which is manifested in a study on Salen–Mn(III) complexes bearing such…”
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Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists by DEYI ZHANG, KOHLMAN, Dan, NELSON, David L. G, SCHAUS, John M, XU, Yao-Chang, KRUSHINSKI, Joseph, LIANG, Sidney, YING, Bai-Ping, REILLY, John E, DINN, Sean R, WAINSCOTT, David B, NUTTER, Suzanne, GOUGH, Wendy

“…Several fused bicyclic systems have been investigated to serve as the core structure of potent and selective 5-HT1F receptor agonists. Replacement of the…”
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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition by Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

“…PF-06651600, a newly discovered potent JAK3-selective inhibitor, is highly efficacious at inhibiting γc cytokine signaling, which is dependent on both JAK1 and…”
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Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization by Davoren, Jennifer E, Nason, Deane, Coe, Jotham, Dlugolenski, Keith, Helal, Christopher, Harris, Anthony R, LaChapelle, Erik, Liang, Sidney, Liu, Yue, O’Connor, Rebecca, Orozco, Christine C, Rai, Brajesh K, Salafia, Michelle, Samas, Brian, Xu, Wenjian, Kozak, Rouba, Gray, David

“…The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part of 40 years. All known…”
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Improved Synthesis of a Macrocyclic Peptide-Like C5aR Antagonist for Intravenous Applications by Feng, Yiqing, Liang, Sidney, Langille, Jonathan, Pierce, Betsy S., Chung, SeungWon, Szeliga, Jan, Wilcox, Glenn, Simonds, Paul, Farley, Kathleen A., Li, Bryan, Garcia-Irizarry, Carmen, Jones, Peter, Lira, Ricardo

“…A multigram scale synthetic procedure for the preparation of a complex and polar macrocyclic peptidic C5aR antagonist is described. The route was developed…”
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Cyclic Peptide C5aR1 Antagonist Design Using Solution Conformational Analysis Derived from Residual Dipolar Couplings by Farley, Kathleen A., Che, Ye, Lira, Ricardo, Jones, Peter, Papaioannou, Nikolaos, Hayward, Matthew, Flanagan, Mark E., Langille, Jonathan, Liang, Sidney, Pierce, Betsy S., Ciszewski, Gregory, Bonin, Paul, Vincent, Fabien, Ramsey, Simeon, Hepworth, David

“…To gain further insight into the conformational properties of small cyclic peptides that bind to the G-protein coupled receptor C5aR1, we report here for the…”
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N-Methyl-5-tert-butyltryptamine:  A Novel, Highly Potent 5-HT1D Receptor Agonist by Xu, Yao-Chang, Schaus, John M, Walker, Clint, Krushinski, Joe, Adham, Nika, Zgombick, John M, Liang, Sidney X, Kohlman, Dan T, Audia, James E

“…It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N, O, or S) on the 5-substituent of the indole. This has led to the…”
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