Search Results - "Liang, Shenghui"
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1
PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system
Published in Nature communications (13-07-2024)“…Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from…”
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2
In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development
Published in eLife (29-01-2019)“…How pancreatic β-cells acquire function in vivo is a long-standing mystery due to the lack of technology to visualize β-cell function in living animals. Here,…”
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3
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory
Published in PLoS genetics (01-01-2018)“…Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon…”
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4
Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture
Published in Scientific reports (01-06-2023)“…The generation of functional β-cells from human pluripotent stem cells (hPSCs) for cell replacement therapy and disease modeling of diabetes is being…”
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5
Morphology of Inclusions and Its Refinement Mechanism in the New P91 Heat-Resistant Pipeline Steel
Published in Metals (Basel ) (01-10-2022)“…A new type of P91 heat-resistant pipeline steel ingot was prepared by feeding Al twisted wire into a steel melt through a multi-point regional micro-supply…”
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6
Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type
Published in Frontiers in genetics (10-02-2020)“…Alport syndrome is a hereditary progressive chronic kidney disease caused by mutations in type IV collagen genes . X-linked Alport syndrome (XLAS) is caused by…”
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7
In vivo Imaging of Calcium Activities from Pancreatic β-cells in Zebrafish Embryos Using Spinning-disc Confocal and Two-photon Light-sheet Microscopy
Published in Bio-protocol (05-12-2021)“…Visualizing the function of pancreatic β-cells has been a long-sought goal for β-cell researchers. Unlike imaging of β-cells in mammalian species with…”
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8
Role of epithelial sodium channels (ENaCs) in endothelial function
Published in Journal of cell science (01-01-2015)“…An increasing number of mechano-sensitive ion channels in endothelial cells (ECs) have been identified in response to blood flow and hydrostatic pressure…”
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9
L-type calcium current in right ventricular outflow tract myocytes of rabbit heart
Published in Science China. Life sciences (2012)“…The mechanism of idiopathic ventricular tachycardia originating from the right ventricular outflow tract (RVOT) is not clear. Many clinical reports have…”
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10
Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic β-cells by activating Phospholipase C signal pathway in diabetic mice
Published in Biochemical and biophysical research communications (10-12-2021)“…In early stage of diabetes, insulin secretion from pancreatic β-cells is increased to deal with the elevated blood glucose. Previous studies have reported that…”
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11
Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide
Published in Oncogene (01-05-2018)“…Warburg effect has been recognized as a hallmark of cancer cells for many years, but its modulation mechanism remains a great focus. Our current study found a…”
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12
Role of epithelial Na+ channels in endothelial function
Published in Journal of cell science (15-01-2016)“…An increasing number of mechano-sensitive ion channels in endothelial cells have been identified in response to blood flow and hydrostatic pressure. However,…”
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13
Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes
Published in Nature communications (14-08-2014)“…Reperfusion-induced ventricular fibrillation (VF) severely threatens the lives of post-myocardial infarction patients. Carbon monoxide (CO)—produced by haem…”
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14
The Effects of Puerarin on Rat Ventricular Myocytes and the Potential Mechanism
Published in Scientific reports (20-10-2016)“…Puerarin, a known isoflavone, is commonly found as a Chinese herb medicine. It is widely used in China to treat cardiac diseases such as angina, cardiac…”
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15
Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system
Published in Cell reports methods (22-05-2023)“…Orbital shaker-based suspension culture systems have been in widespread use for differentiating human pluripotent stem cell (hPSC)-derived pancreatic…”
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16
Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters
Published in Journal of visualized experiments (23-06-2023)“…Differentiation of human pluripotent stem cells (hPSCs) into insulin-secreting beta cells provides material for investigating beta cell function and diabetes…”
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17
CRL4 antagonizes SCF.sup.Fbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory
Published in PLoS genetics (25-01-2018)“…Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon…”
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Journal Article -
18
In vivo imaging of [beta]-cell function reveals glucose-mediated heterogeneity of [beta]-cell functional development
Published in eLife (29-01-2019)“…How pancreatic [beta]-cells acquire function in vivo is a long-standing mystery due to the lack of technology to visualize [beta]-cell function in living…”
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19
Quantitative Analysis of Paleoatmospheric CO2 Level Based on Stomatal Characters of Fossil Ginkgo from Jurassic to Cretaceous in China
Published in Acta geologica Sinica (Beijing) (01-12-2007)“…A better theoretical and practical understanding of the linkage between paleo-CO2 and climate during geological history is important to enhance the sustainable…”
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