Search Results - "Liang, Qiansheng"

The binding and mechanism of a positive allosteric modulator of Kv3 channels by Liang, Qiansheng, Chi, Gamma, Cirqueira, Leonardo, Zhi, Lianteng, Marasco, Agostino, Pilati, Nadia, Gunthorpe, Martin J., Alvaro, Giuseppe, Large, Charles H., Sauer, David B., Treptow, Werner, Covarrubias, Manuel

“…Small-molecule modulators of diverse voltage-gated K + (Kv) channels may help treat a wide range of neurological disorders. However, developing effective…”
Get full text

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain by Chi, Gamma, Liang, Qiansheng, Sridhar, Akshay, Cowgill, John B., Sader, Kasim, Radjainia, Mazdak, Qian, Pu, Castro-Hartmann, Pablo, Venkaya, Shayla, Singh, Nanki Kaur, McKinley, Gavin, Fernandez-Cid, Alejandra, Mukhopadhyay, Shubhashish M. M., Burgess-Brown, Nicola A., Delemotte, Lucie, Covarrubias, Manuel, Dürr, Katharina L.

“…Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in…”
Get full text

Novel Activation of Voltage-gated K+ Channels by Sevoflurane by Barber, Annika F., Liang, Qiansheng, Covarrubias, Manuel

“…Voltage-gated ion channels are modulated by halogenated inhaled general anesthetics, but the underlying molecular mechanisms are not understood. Alkanols and…”
Get full text

Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action by Liang, Qiansheng, Anderson, Warren D, Jones, Shelly T, Souza, Caio S, Hosoume, Juliana M, Treptow, Werner, Covarrubias, Manuel

“…Inhalational general anesthesia results from the poorly understood interactions of haloethers with multiple protein targets, which prominently includes ion…”
Get full text

Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition by Woll, Kellie A, Weiser, Brian P, Liang, Qiansheng, Meng, Tao, McKinstry-Wu, Andrew, Pinch, Benika, Dailey, William P, Gao, Wei Dong, Covarrubias, Manuel, Eckenhoff, Roderic G

“…Propofol is a widely used intravenous general anesthetic. We synthesized 2-fluoro-1,3-diisopropylbenzene, a compound that we call “fropofol”, to directly…”
Get full text

Tanshinone IIA Selectively Enhances Hyperpolarization-Activated Cyclic Nucleotide–Modulated (HCN) Channel Instantaneous Current by Liang, Qiansheng, Yang, Le, Wang, Zhaohua, Huang, Sufang, Li, Shusheng, Yang, Guangtian

“…Tanshinone IIA, one of the main active components from the Chinese herb Danshen, is widely used to treat cardiovascular diseases in Asian countries, especially…”
Get full text

Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway by Yang, Le, Zou, Xiaojing, Liang, Qiansheng, Chen, Hao, Feng, Jun, Yan, Li, Wang, Zhaohua, Zhou, Daixing, Li, Shusheng, Yao, Shanglong, Zheng, Zhi

Get full text

Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics by Yang, Elaine, Zhi, Lianteng, Liang, Qiansheng, Covarrubias, Manuel

“…Voltage-gated ion channels (VGICs) of excitable tissues are emerging as targets likely involved in both the therapeutic and toxic effects of inhaled and…”
Get more information

A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction by Clatot, Jerome, Currin, Christopher B, Liang, Qiansheng, Pipatpolkai, Tanadet, Massey, Shavonne L, Helbig, Ingo, Delemotte, Lucie, Vogels, Tim P, Covarrubias, Manuel, Goldberg, Ethan M

“…De novo heterozygous variants in encoding the voltage-gated potassium (K ) channel subunit Kv3.2 are a recently described cause of developmental and epileptic…”
Get full text

PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity‐dependent manner by Zemel, Benjamin M., Zhi, Lianteng, Brown, Eric V., Tymanskyj, Stephen R., Liang, Qiansheng, Covarrubias, Manuel

“…The voltage‐gated potassium channel Kv3.4 is a crucial regulator of nociceptive signaling in the dorsal root ganglion (DRG) and the dorsal horn of the spinal…”
Get full text

A New Class of Positive Gating Modulators of hKv3.2 Channels: Insights into the Mechanism of Action by Liang, Qiansheng, Alvaro, Giuseppe, Large, Charles, Covarrubias, Manuel

Get full text

Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels by Bu, Weiming, Liang, Qiansheng, Zhi, Lianteng, Maciunas, Lina, Loll, Patrick J., Eckenhoff, Roderic G., Covarrubias, Manuel

“…Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is…”
Get full text

Sevoflurane: A Potent General Anesthetic Enhancer of Kv Channel Activation by Barber, Annika F., Liang, Qiansheng, Covarrubias, Manuel

Get full text

Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation by Woll, Kellie A, Peng, Wesley, Liang, Qiansheng, Zhi, Lianteng, Jacobs, Jack A, Maciunas, Lina, Bhanu, Natarajan, Garcia, Benjamin A, Covarrubias, Manuel, Loll, Patrick J, Dailey, William P, Eckenhoff, Roderic G

“…Sevoflurane is a commonly used inhaled general anesthetic. Despite this, its mechanism of action remains largely elusive. Compared to other anesthetics,…”
Get full text

Molecular Mapping of General Anesthetic Sites in a Voltage-Gated Ion Channel by Barber, Annika F., Liang, Qiansheng, Amaral, Cristiano, Treptow, Werner, Covarrubias, Manuel

“…Several voltage-gated ion channels are modulated by clinically relevant doses of general anesthetics. However, the structural basis of this modulation is not…”
Get full text

Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy by Feng, Huijie, Clatot, Jerome, Kaneko, Keisuke, Flores-Mendez, Marco, Wengert, Eric R., Koutcher, Carly, Hoddeson, Emily, Lopez, Emily, Lee, Demetrius, Arias, Leroy, Liang, Qiansheng, Zhang, Xiaohong, Somarowthu, Ala, Covarrubias, Manuel, Gunthorpe, Martin J., Large, Charles H., Akizu, Naiara, Goldberg, Ethan M.

“…The recurrent variant KCNC1-p.Arg320His causes progressive myoclonus epilepsy (EPM) type 7, defined by progressive myoclonus, epilepsy, and ataxia, and is…”
Get full text

Changes of c-fos and c-jun mRNA Expression in Angiotensin Ⅱ-induced Cardiomyocyte Hypertrophy and Effects of Sodium Tanshinone Ⅱ A Sulfonate by Daixing ZHOU, Qiansheng LIANG, Xuexin HE, Chengye ZHAN

“…R5; Summary: The changes of proto-oncogene c-fos and c-jun mRNA expression in angiotensin Ⅱ (Ang Ⅱ)-induced hypertrophy and effects of sodium tanshinone Ⅱ A…”
Get full text

Novel Modulation of a Kv1.2 Chimera by Volatile Anesthetics by Liang, Qiansheng, Barber, Annika F., Souza, Caio S., Treptow, Werner, Covarrubias, Manuel

Get full text

Propagation and Electrical Impedance Changes due to Ischemia, Hypoxia and Reperfusion in Mouse Hearts by Qiansheng Liang, Sohn, K., Punske, B.B.

“…The purpose of this study is to quantitatively characterize major electrical markers of cardiac ischemia in normal mouse hearts to establish a set of baseline…”
Get full text

Comparison of arrhythmias among different left ventricular geometric patterns in essential hypertension by Zheng, Z, Zhou, R, Liang, Q

“…The differences of arrhythmias among distinct left ventricular geometric patterns in the patients with essential hypertension were studied. 179 patients with…”
Get full text