Search Results - "Liang, Lu‐Jun"

Chemical Synthesis of Activity‐Based E2‐Ubiquitin Probes for the Structural Analysis of E3 Ligase‐Catalyzed Transthiolation by Liang, Lu‐Jun, Chu, Guo‐Chao, Qu, Qian, Zuo, Chong, Mao, Junxiong, Zheng, Qingyun, Chen, Jingnan, Meng, Xianbin, Jing, Yangwode, Deng, Haiteng, Li, Yi‐Ming, Liu, Lei

“…Activity‐based E2 conjugating enzyme (E2)‐ubiquitin (Ub) probes have recently emerged as effective tools for studying the molecular mechanism of E3 ligase…”
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Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide‐Linked Ub Isomer by Tang, Shan, Liang, Lu‐Jun, Si, Yan‐Yan, Gao, Shuai, Wang, Jia‐Xing, Liang, Jun, Mei, Ziqing, Zheng, Ji‐Shen, Liu, Lei

“…Chemical ubiquitination is an effective approach for accessing structurally defined, atypical ubiquitin (Ub) chains that are difficult to prepare by other…”
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Development and application of ubiquitin-based chemical probes by Sui, Xin, Wang, Yu, Du, Yun-Xiang, Liang, Lu-Jun, Zheng, Qingyun, Li, Yi-Ming, Liu, Lei

“…Protein ubiquitination regulates almost every process in eukaryotic cells. The study of the many enzymes involved in the ubiquitination system and the…”
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Thioester‐Assisted Sortase‐A‐Mediated Ligation by Zuo, Chong, Ding, Ruichao, Wu, Xiangwei, Wang, Yuanxia, Chu, Guo‐Chao, Liang, Lu‐Jun, Ai, Huasong, Tong, Ze‐Bin, Mao, Junxiong, Zheng, Qingyun, Wang, Tian, Li, Zichen, Liu, Lei, Sun, Demeng

“…Sortase A (SrtA)‐mediated ligation, a popular method for protein labeling and semi‐synthesis, is limited by its reversibility and dependence on the LPxTG…”
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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1 by Wu, Xiangwei, Du, Yunxiang, Liang, Lu-Jun, Ding, Ruichao, Zhang, Tianyi, Cai, Hongyi, Tian, Xiaolin, Pan, Man, Liu, Lei

“…Ubiquitination, catalyzed usually by a three-enzyme cascade (E1, E2, E3), regulates various eukaryotic cellular processes. E3 ligases are the most critical…”
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Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time-Resolved Monitoring of Substrate Ubiquitination in Live Cells by Liang, Lu-Jun, Wang, Yu, Hua, Xiao, Yuan, Rujing, Xia, Qiong, Wang, Rongtian, Li, Chuntong, Chu, Guo-Chao, Liu, Lei, Li, Yi-Ming

“…Dynamic monitoring of intracellular ubiquitin (Ub) conjugates is instrumental to understanding the Ub regulatory machinery. Although many biochemical…”
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One-pot ligation strategy for atypical ubiquitin chains synthesis by using the trifluoroacetamidomethyl-protected isopeptide-linked Ub (Tfacm-isoUb) unit by Si, Yan-Yan, Liang, Lu-Jun, Tang, Shan, Qi, Yun-Kun, Huang, Yong, Zheng, Ji-Shen

“…[Display omitted] •A new one-pot ligation approach was developed for the synthesis of atypical Ub chains based on the Tfacm-isoUb building block.•The key…”
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Differences between low and high grade fetal adenocarcinoma of the lung: a clinicopathological and molecular study by Zhang, Jing, Sun, Jian, Liang, Xiao-Long, Lu, Jun-Liang, Luo, Yu-Feng, Liang, Zhi-Yong

“…Fetal adenocarcinoma of the lung (FLAC) is a rare entity of lung cancer. It is classified into low-grade fetal adenocarcinoma (L-FLAC) and high-grade fetal…”
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Bidirectional associations between sensorineural hearing loss and depression and anxiety: a meta-analysis by Zhang, Zhi-Qiang, Li, Jing-Yang, Ge, Si-Tong, Ma, Tian-Yi, Li, Fu-Yao, Lu, Jun-Liang, Si, Shu-Rui, Cui, Zhe-Zhu, Jin, Yu-Lian, Jin, Xiang-Hua

“…Recently, the prevalence of sensorineural hearing loss (SNL) has been increasing, and several studies have suggested that depression, anxiety, and SNL may be…”
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Circulating free DNA in the era of precision oncology:Pre-and post-analytical concerns by Lu, Jun-Liang, Liang, Zhi-Yong

“…Cancer treatment has entered the era of precision medicine, where knowledge of a patient's genetic profile is used to facilitate early diagnosis, drug…”
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Copper-Catalyzed/Promoted Cross-coupling of gem-Diborylalkanes with Nonactivated Primary Alkyl Halides: An Alternative Route to Alkylboronic Esters by Zhang, Zhen-Qi, Yang, Chu-Ting, Liang, Lu-Jun, Xiao, Bin, Lu, Xi, Liu, Jing-Hui, Sun, Yan-Yan, Marder, Todd B., Fu, Yao

“…The first copper-catalyzed/promoted sp3-C Suzuki–Miyaura coupling reaction of gem-diborylalkanes with nonactivated electrophilic reagents is reported. Not only…”
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Efficacy and safety of tarcrolimus cream 0.1% in the treatment of vitiligo by Xu, Ai-E., Zhang, Di-Min, Wei, Xiao-Dong, Huang, Bo, Lu, Liang-Jun

“…Background  Vitiligo is an acquired, pigmentary skin disorder which is disfiguring and difficult to treat. Phototherapy and application of topical…”
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Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide‐Linked Ub Isomer by Tang, Shan, Liang, Lu‐Jun, Si, Yan‐Yan, Gao, Shuai, Wang, Jia‐Xing, Liang, Jun, Mei, Ziqing, Zheng, Ji‐Shen, Liu, Lei

“…Chemical ubiquitination is an effective approach for accessing structurally defined, atypical ubiquitin (Ub) chains that are difficult to prepare by other…”
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Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin by Tan, Xiang-Long, Pan, Man, Zheng, Yong, Gao, Shuai, Liang, Lu-Jun, Li, Yi-Ming

“…Phosphorylation of S403 or S407 of the autophagic receptor protein p62 has recently been discovered to enhance the binding of p62 with ubiquitinated protein…”
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Chemical tools for E3 ubiquitin ligase study by Jing, Yangwode, Zuo, Chong, Du, Yun-Xiang, Mao, Junxiong, Ding, Ruichao, Zhang, Jiachen, Liang, Lu-Jun, Qu, Qian

“…E3 ubiquitin ligases catalyze the final step of ubiquitylation, a crucial post-translational modification involved in almost every process in eukaryotic cells…”
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Biochemical properties of K11,48-branched ubiquitin chains by Liang, Lu-Jun, Si, Yanyan, Tang, Shan, Huang, Dongliang, Wang, Zhipeng A., Tian, Changlin, Zheng, Ji-Shen

“…[Display omitted] The affinities of chemically synthetic linkage- and length-defined K11,48-branched ubiquitin chains binding to ubiquitin receptor S5a were…”
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Genomic profiling in amyloid light-chain amyloidosis reveals mutation profiles associated with overall survival by Huang, Xu-Fei, Jian, Sun, Lu, Jun-Liang, Shen, Kai-Ni, Feng, Jun, Zhang, Cong-Li, Tian, Zhuang, Wang, Jia-Li, Lei, Wan-Jun, Cao, Xin-Xin, Zhou, Dao-bin, Liang, Zhi-Yong, Li, Jian

“…Background: Amyloid light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibres derived from immunoglobulin that can lead to…”
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Thioester‐Assisted Sortase‐A‐Mediated Ligation by Zuo, Chong, Ding, Ruichao, Wu, Xiangwei, Wang, Yuanxia, Chu, Guo‐Chao, Liang, Lu‐Jun, Ai, Huasong, Tong, Ze‐Bin, Mao, Junxiong, Zheng, Qingyun, Wang, Tian, Li, Zichen, Liu, Lei, Sun, Demeng

“…Sortase A (SrtA)‐mediated ligation, a popular method for protein labeling and semi‐synthesis, is limited by its reversibility and dependence on the LPxTG…”
Get full text

Chemical Synthesis of Activity‐Based E2‐Ubiquitin Probes for the Structural Analysis of E3 Ligase‐Catalyzed Transthiolation by Liang, Lu‐Jun, Chu, Guo‐Chao, Qu, Qian, Zuo, Chong, Mao, Junxiong, Zheng, Qingyun, Chen, Jingnan, Meng, Xianbin, Jing, Yangwode, Deng, Haiteng, Li, Yi‐Ming, Liu, Lei

“…Activity‐based E2 conjugating enzyme (E2)‐ubiquitin (Ub) probes have recently emerged as effective tools for studying the molecular mechanism of E3 ligase…”
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Liquid film dryout model for predicting critical heat flux in annular two-phase flow by Jiao, Bo, Qiu, Li-min, Lu, Jun-liang, Gan, Zhi-hua

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