Search Results - "Liang, Lingli"

DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons by Zhao, Jian-Yuan, Liang, Lingli, Gu, Xiyao, Li, Zhisong, Wu, Shaogen, Sun, Linlin, Atianjoh, Fidelis E., Feng, Jian, Mo, Kai, Jia, Shushan, Lutz, Brianna Marie, Bekker, Alex, Nestler, Eric J., Tao, Yuan-Xiang

“…Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA…”
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A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression by Du, Shibin, Wu, Shaogen, Feng, Xiaozhou, Wang, Bing, Xia, Shangzhou, Liang, Lingli, Zhang, Li, Govindarajalu, Gokulapriya, Bunk, Alexander, Kadakia, Feni, Mao, Qingxiang, Guo, Xinying, Zhao, Hui, Berkman, Tolga, Liu, Tong, Li, Hong, Stillman, Jordan, Bekker, Alex, Davidson, Steve, Tao, Yuan-Xiang

“…Maladaptive changes of nerve injury-associated genes in dorsal root ganglia (DRGs) are critical for neuropathic pain genesis. Emerging evidence supports the…”
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A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons by Zhao, Xiuli, Tang, Zongxiang, Zhang, Hongkang, Atianjoh, Fidelis E, Zhao, Jian-Yuan, Liang, Lingli, Wang, Wei, Guan, Xiaowei, Kao, Sheng-Chin, Tiwari, Vinod, Gao, Yong-Jing, Hoffman, Paul N, Cui, Hengmi, Li, Min, Dong, Xinzhong, Tao, Yuan-Xiang

“…Zhao and colleagues find that neuropathic pain is accompanied by an increase in the expression of an antisense long noncoding RNA (lncRNA) that downregulates…”
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Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain by Cui, Lian, Miao, Xuerong, Liang, Lingli, Abdus-Saboor, Ishmail, Olson, William, Fleming, Michael S., Ma, Minghong, Tao, Yuan-Xiang, Luo, Wenqin

“…The gate control theory (GCT) of pain proposes that pain- and touch-sensing neurons antagonize each other through spinal cord dorsal horn (DH) gating neurons…”
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Dorsal root ganglion transcriptome analysis following peripheral nerve injury in mice by Wu, Shaogen, Marie Lutz, Brianna, Miao, Xuerong, Liang, Lingli, Mo, Kai, Chang, Yun-Juan, Du, Peicheng, Soteropoulos, Patricia, Tian, Bin, Kaufman, Andrew G., Bekker, Alex, Hu, Yali, Tao, Yuan-Xiang

“…Background Peripheral nerve injury leads to changes in gene expression in primary sensory neurons of the injured dorsal root ganglia. These changes are…”
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Electro-acupuncture Suppresses AXL Expression in Dorsal Root Ganglion Neurons and Enhances Analgesic Effect of AXL Inhibitor in Spinal Nerve Ligation Induced-Neuropathic Pain Rats by Wei, Siqi, Chang, Shuyang, Dong, Yue, Xu, Linping, Yuan, Xiaocui, Jia, Hong, Zhang, Jun, Liang, Lingli

“…Electro-acupuncture (EA) has been used for clinic analgesia for many years. However, its mechanisms are not fully understood. We recently reported that AXL, a…”
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CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons by Yang, Yong, Wen, Jing, Zheng, Bixin, Wu, Shaogen, Mao, Qingxiang, Liang, Lingli, Li, Zhisong, Bachmann, Thomas, Bekker, Alex, Tao, Yuan-Xiang

“…Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is…”
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mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury by Liang, Lingli, Tao, Bo, Fan, Longchang, Yaster, Myron, Zhang, Yi, Tao, Yuan-Xiang

“…Abstract Protein translation controlled through activation of mammalian target of rapamycin (mTOR) participates in many physiological and pathological…”
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Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia by Xu, Ji-Tian, Zhao, Jian-Yuan, Zhao, Xiuli, Ligons, Davinna, Tiwari, Vinod, Atianjoh, Fidelis E, Lee, Chun-Yi, Liang, Lingli, Zang, Weidong, Njoku, Dolores, Raja, Srinivasa N, Yaster, Myron, Tao, Yuan-Xiang

“…The development of opioid-induced analgesic tolerance and hyperalgesia is a clinical challenge for managing chronic pain. Adaptive changes in protein…”
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Author Correction: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons by Zhao, Jian-Yuan, Liang, Lingli, Gu, Xiyao, Li, Zhisong, Wu, Shaogen, Sun, Linlin, Atianjoh, Fidelis E., Feng, Jian, Mo, Kai, Jia, Shushan, Lutz, Brianna Marie, Bekker, Alex, Nestler, Eric J., Tao, Yuan-Xiang

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain by Mao, Qingxiang, Tian, Lixia, Wei, Jianxiong, Zhou, Xiaoqiong, Cheng, Hong, Zhu, Xuan, Li, Xiang, Gao, Zihao, Zhang, Xi, Liang, Lingli

“…The microtubule-stabilizing drug paclitaxel (PTX) is a chemotherapeutic agent widely prescribed for the treatment of various tumor types. The main adverse…”
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Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons by Liang, Lingli, Fan, Longchang, Tao, Bo, Yaster, Myron, Tao, Yuan-Xiang

“…Voltage-gated sodium channels (Nav) are essential for the generation and conduction of action potentials. Peripheral inflammation increases the expression of…”
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Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn by Liu, Siyi, Yang, Shuting, Zhu, Xuan, Li, Xiang, Zhang, Xi, Zhou, Xiaoqiong, Cheng, Hong, Huo, Fu-Quan, Mao, Qingxiang, Liang, Lingli

“…Inflammation and nerve injury promote astrocyte activation, which regulates the development and resolution of pain, in the spinal dorsal horn. APOE regulates…”
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Short-term pre- and post-Operative Stress Prolongs Incision-Induced Pain Hypersensitivity without Changing Basal Pain Perception by Cao, Jing, Wang, Po-Kai, Tiwari, Vinod, Liang, Lingli, Lutz, Brianna Marie, Shieh, Kun-Ruey, Zang, Wei-Dong, Kaufman, Andrew G., Bekker, Alex, Gao, Xiao-Qun, Tao, Yuan-Xiang

“…Background Chronic stress has been reported to increase basal pain sensitivity and/or exacerbate existing persistent pain. However, most surgical patients have…”
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Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain by Cui, Lian, Miao, Xuerong, Liang, Lingli, Abdus-Saboor, Ishmail, Olson, William, Fleming, Michael S., Ma, Minghong, Tao, Yuan-Xiang, Luo, Wenqin

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AXL signaling in primary sensory neurons contributes to chronic compression of dorsal root ganglion-induced neuropathic pain in rats by Liang, Lingli, Zhang, Jun, Tian, Lixia, Wang, Shuo, Xu, Linping, Wang, Yingxuan, Guo-Shuai, Qingying, Dong, Yue, Chen, Yu, Jia, Hong, Yang, Xuewei, Yuan, Chunmei

“…Low back pain is a chronic, highly prevalent, and hard-to-treat condition in the elderly. Clinical studies indicate that AXL, which belongs to the tyrosine…”
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The upregulation of EGFR in the dorsal root ganglion contributes to chronic compression of dorsal root ganglions-induced neuropathic pain in rats by Wang, Shuo, Liu, Siyi, Xu, Linping, Zhu, Xuan, Liu, Wanyuan, Tian, Lixia, Chen, Yu, Wang, Yuying, Nagendra, Borra V Padma, Jia, Shushan, Liang, Lingli, Huo, Fu-Quan

“…The epidermal growth factor receptor (EGFR) located in dorsal root ganglion has been found as a new target for chronic pain treatment. However, it is not clear…”
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G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury by Liang, Lingli, Zhao, Jian-Yuan, Gu, Xiyao, Wu, Shaogen, Mo, Kai, Xiong, Ming, Marie Lutz, Brianna, Bekker, Alex, Tao, Yuan-Xiang

“…Neuropathic pain, a distressing and debilitating disorder, is still poorly managed in clinic. Opioids, like morphine, remain the mainstay of prescribed…”
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Role of MicroRNA-143 in Nerve Injury-Induced Upregulation of Dnmt3a Expression in Primary Sensory Neurons by Xu, Bo, Cao, Jing, Zhang, Jun, Jia, Shushan, Wu, Shaogen, Mo, Kai, Wei, Guihua, Liang, Lingli, Miao, Xuerong, Bekker, Alex, Tao, Yuan-Xiang

“…Peripheral nerve injury increased the expression of the DNA methyltransferase 3A ( ) mRNA and its encoding Dnmt3a protein in injured dorsal root ganglia (DRG)…”
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Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development by Liu, Huahua, Zhou, Rui, Li, Shanshan, Dong, Jinling, Fang, Yuan, Luo, Yuru, Su, Hongyu, Lai, Baochang, Liang, Lingli, Zhang, Donghong, Zhang, Yanmin, Shyy, John Y-J., Zhou, Bin, Yuan, Zuyi, Wang, Yidong

“…Epigenetic regulation of heart development remains incompletely understood. Here we show that LSD1, a histone demethylase, plays a crucial role in regulating…”
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