Search Results - "Liang, Kun"

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine by Dey, Anwesha, Varelas, Xaralabos, Guan, Kun-Liang

“…The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development, epithelial homeostasis, tissue regeneration, wound…”
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mTOR as a central hub of nutrient signalling and cell growth by Kim, Joungmok, Guan, Kun-Liang

“…The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth…”
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The multifaceted role of autophagy in cancer by Russell, Ryan C, Guan, Kun‐Liang

“…Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular homeostasis. Cellular stress caused by starvation, organelle…”
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mTOR: a pharmacologic target for autophagy regulation by Kim, Young Chul, Guan, Kun-Liang

“…mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of…”
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Interplay between YAP/TAZ and Metabolism by Koo, Ja Hyun, Guan, Kun-Liang

“…Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are two homologous transcriptional coactivators that promote cell…”
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Mechanisms of Hippo pathway regulation by Meng, Zhipeng, Moroishi, Toshiro, Guan, Kun-Liang

“…The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in…”
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The Hippo Pathway: Biology and Pathophysiology by Ma, Shenghong, Meng, Zhipeng, Chen, Rui, Guan, Kun-Liang

“…The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade…”
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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer by Yu, Fa-Xing, Zhao, Bin, Guan, Kun-Liang

“…Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting…”
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The Hippo pathway: regulators and regulations by Yu, Fa-Xing, Guan, Kun-Liang

“…Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The…”
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The Hippo signaling pathway in stem cell biology and cancer by Mo, Jung-Soon, Park, Hyun Woo, Guan, Kun-Liang

“…The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a…”
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The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway by Hong, Wanjin, Guan, Kun-Liang

“…► The Hippo pathway plays a key role in organ size control and dysregulation of the pathway contributes to tumorigenesis. ► The YAP/TAZ transcription…”
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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal by Zhao, Bin, Tumaneng, Karen, Guan, Kun-Liang

“…Precise control of organ size is crucial during animal development and regeneration. In Drosophila and mammals, studies over the past decade have uncovered a…”
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The emerging roles of YAP and TAZ in cancer by Moroishi, Toshiro, Hansen, Carsten Gram, Guan, Kun-Liang

“…YAP and TAZ are the major downstream effectors of the Hippo pathway. This Progress article summarizes the latest findings regarding the biological functions of…”
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Regulation of the Hippo Pathway Transcription Factor TEAD by Lin, Kimberly C., Park, Hyun Woo, Guan, Kun-Liang

“…The TEAD transcription factor family is best known for transcriptional output of the Hippo signaling pathway and has been implicated in processes such as…”
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Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity by Li, Xiaoya, Wang, Tian‐Xiang, Huang, Xinmei, Li, Yue, Sun, Tiange, Zang, Shufei, Guan, Kun‐Liang, Xiong, Yue, Liu, Jun, Yuan, Hai‐Xin

“…Background NASH is one of the fastest growing liver diseases that leads to severe steatosis, inflammation and ultimately liver injury. However, the…”
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AMPK and autophagy in glucose/glycogen metabolism by Ha, Joohun, Guan, Kun-Liang, Kim, Joungmok

“…Glucose/glycogen metabolism is a primary metabolic pathway acting on a variety of cellular needs, such as proliferation, growth, and survival against stresses…”
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YAP and TAZ: a nexus for Hippo signaling and beyond by Hansen, Carsten Gram, Moroishi, Toshiro, Guan, Kun-Liang

“…Highlights • YAP and TAZ are major downstream effectors of the Hippo pathway. • YAP and TAZ function as signaling manifolds in the nucleus and the cytoplasm. •…”
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 by Guan, Kun-Liang, Kim, Joungmok, Kundu, Mondira, Viollet, Benoit

“…A molecular mechanism that links the mTOR and autophagy pathways is now revealed. Depending on nutrient availability, the AMPK and mTOR kinases differentially…”
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Differential regulation of mTORC1 by leucine and glutamine by Jewell, Jenna L., Kim, Young Chul, Russell, Ryan C., Yu, Fa-Xing, Park, Hyun Woo, Plouffe, Steven W., Tagliabracci, Vincent S., Guan, Kun-Liang

“…The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth. Amino acids stimulate…”
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Autophagy regulation by nutrient signaling by Russell, Ryan C, Yuan, Hai-Xin, Guan, Kun-Liang

“…The ability of cells to respond to changes in nutrient availability is essential for the maintenance of metabolic ho- meostasis and viability. One of the key…”
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