Search Results - "Lian, Zhe"

Tissue‐Resident Memory CD8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjögren's Syndrome by Gao, Cai‐Yue, Yao, Yuan, Li, Liang, Yang, Shu‐Han, Chu, Hui, Tsuneyama, Koichi, Li, Xiao‐Mei, Gershwin, M. Eric, Lian, Zhe‐Xiong

“…Objective Although a role for CD4+ T cells in the pathogenesis of Sjögren's syndrome (SS) has been documented, the pathogenic significance of CD8+ T cells is…”
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Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review by Ma, Wen-Tao, Chang, Christopher, Gershwin, M. Eric, Lian, Zhe-Xiong

“…The etiology of autoimmune diseases is due to a combination of genetic predisposition and environmental factors that alter the expression of immune regulatory…”
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Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect by Tang, Wei, Zhao, Zhibin, Chong, Yuanyuan, Wu, Chengfan, Liu, Qingzhi, Yang, Jingbo, Zhou, Rongbin, Lian, Zhe-Xiong, Liang, Gaolin

“…Many chronic liver diseases will advance to hepatic fibrosis and, if without timely intervention, liver cirrhosis or even hepatocellular carcinoma…”
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[2,2] Paracyclophanes-based double helicates for constructing artificial light-harvesting systems and white LED device by Lian, Zhe, He, Jing, Liu, Lin, Fan, Yanqing, Chen, Xuebo, Jiang, Hua

“…The construction of efficient artificial light-harvesting systems (ALHSs) is of vital importance in utilizing solar energy. Herein, we report the non-covalent…”
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Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy by Shen, Song, Li, Hong-Jun, Chen, Kai-Ge, Wang, Yu-Cai, Yang, Xian-Zhu, Lian, Zhe-Xiong, Du, Jin-Zhi, Wang, Jun

“…Chemoimmunotherapy, which combines chemotherapeutics with immune-modulating agents, represents an appealing approach for improving cancer therapy. To optimize…”
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Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer by Yin, Tingting, Zhao, Zhi-Bin, Guo, Jing, Wang, Tianchen, Yang, Jing-Bo, Wang, Chao, Long, Jie, Ma, Shisong, Huang, Qiang, Zhang, Kaiguang, Ma, Xiaopeng, Liu, Chenhai, Liu, Suling, Lian, Zhe-Xiong, Yang, Zhenye

“…The Aurora A inhibitor alisertib shows encouraging activities in clinical trials against advanced breast cancer. However, it remains unclear whether and how…”
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IL-17 constrains natural killer cell activity by restraining IL-15–driven cell maturation via SOCS3 by Wang, Xuefu, Sun, Rui, Hao, Xiaolei, Lian, Zhe-Xiong, Wei, Haiming, Tian, Zhigang

“…Increasing evidence demonstrates that IL-17A promotes tumorigenesis, metastasis, and viral infection. Natural killer (NK) cells are critical for defending…”
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Spontaneous development of an autoimmune hepatitis – primary biliary cholangitis overlap syndrome in dnTGFβRII Aire−/− mice by Long, Jie, Yang, Si‐Yu, Huang, Meng‐Xing, Luo, Pan‐Yue, Li, Liang, Tsuneyama, Koichi, Ansari, Aftab A, Lu, Ling, Gershwin, M Eric, Lian, Zhe‐Xiong, Zhao, Zhi‐Bin

“…Autoimmune regulator (Aire) and TGF‐β signaling play important roles in central tolerance and peripheral tolerance, respectively, by eliminating or suppressing…”
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OMIP 071: A 31‐Parameter Flow Cytometry Panel for In‐Depth Immunophenotyping of Human T‐Cell Subsets Using Surface Markers by Wang, Song‐Rong, Zhong, Na, Zhang, Xin‐Mei, Zhao, Zhi‐Bin, Balderas, Robert, Li, Liang, Lian, Zhe‐Xiong

“…Dissecting the functional diversity of T cells is critical in elucidating mechanisms and in developing therapies for various diseases. Here, we designed a…”
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Nanosized Carbon Macrocycles Based on a Planar Chiral Pseudo Meta‐[2.2]Paracyclophane by He, Jing, Yu, Mohan, Pang, Maofu, Fan, Yanqing, Lian, Zhe, Wang, Ying, Wang, Wenguang, Liu, Yajun, Jiang, Hua

“…Structural designs combining cycloparaphenylenes (CPPs) backbone with planar chiral [2.2]paracyclophane ([2.2]PCP) lead to optical‐active chiral macrocycles…”
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Immunobiology of T Cells in Sjögren’s Syndrome by Yao, Yuan, Ma, Jin-Fen, Chang, Christopher, Xu, Ting, Gao, Cai-Yue, Gershwin, M. Eric, Lian, Zhe-Xiong

“…Sjögren’s syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis sicca (eye dryness), and other systematic…”
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In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance by Zhang, Yue, Shen, Song, Zhao, Gui, Xu, Cong-Fei, Zhang, Hou-Bing, Luo, Ying-Li, Cao, Zhi-Ting, Shi, Jia, Zhao, Zhi-Bin, Lian, Zhe-Xiong, Wang, Jun

“…Organ transplantation is the only effective method to treat end-stage organ failure. However, it is continuously plagued by immune rejection, which is mostly…”
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Mutations in the notch signalling pathway are associated with enhanced anti‐tumour immunity in colorectal cancer by Wang, Fei, Long, Jie, Li, Liang, Zhao, Zhi‐bin, Wei, Fang, Yao, Yuan, Qiu, Wen‐Jing, Wu, Zi‐Xin, Luo, Qing‐Qing, Liu, Wei, Quan, Yi‐Bo, Lian, Zhe‐Xiong, Cao, Jie

“…The Notch signalling pathway is involved in the development of several cancers, including colorectal cancer (CRC). However, whether mutations in this pathway…”
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Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid by Tsuda, Masanobu, Moritoki, Yuki, Lian, Zhe-Xiong, Zhang, Weici, Yoshida, Katsunori, Wakabayashi, Kanji, Yang, Guo-Xiang, Nakatani, Toshio, Vierling, John, Lindor, Keith, Gershwin, M. Eric, Bowlus, Christopher L.

“…The aim of this study was to determine the safety and potential efficacy of B‐cell depletion with the anti‐CD20 monoclonal antibody rituximab in patients with…”
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Traditional Chinese Medicine and Immune Regulation by Ma, Hong-Di, Deng, Yan-Ru, Tian, Zhigang, Lian, Zhe-Xiong

“…Traditional Chinese medicines (TCMs) have a long history in Asian countries and are traditionally used to prevent and treat a variety of diseases. The rising…”
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Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases by Huang, Chuan, Zhu, Hao-Xian, Yao, Yuan, Bian, Zhen-Hua, Zheng, Yu-Jian, Li, Liang, Moutsopoulos, Haralampos M., Gershwin, M. Eric, Lian, Zhe-Xiong

“…During host immune response, an initial and sufficient activation is required to avoid infection and cancer, yet an excessive activation bears the risk of…”
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Gut microbiota contributes to sexual dimorphism in murine autoimmune cholangitis by Huang, Meng‐Xing, Yang, Si‐Yu, Luo, Pan‐Yue, Long, Jie, Liu, Qing‐Zhi, Wang, Jinjun, He, Yi, Li, Liang, Zhao, Zhi‐Bin, Lian, Zhe‐Xiong

“…The data demonstrated that a transgenic murine model of primary biliary cholangitis (PBC), expressing dominant negative TGF‐β receptor Ⅱ (dnTGFβRⅡ) under the…”
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Efficacy and safety profile of angiotensin receptor neprilysin inhibitors in the management of heart failure: a systematic review and meta-analysis of randomized controlled trials by Gao, Juan, Zhao, Cong, Zhang, Wen-Zhong, Liu, Song, Xin, Hui, Lian, Zhe-Xun

“…Several guidelines have recommended the use of angiotensin receptor neprilysin inhibitors (ARNIs) as replacement for angiotensin-converting enzyme inhibitors…”
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FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor-associated macrophages by Yang, Jing-Bo, Zhao, Zhi-Bin, Liu, Qing-Zhi, Hu, Tai-Dou, Long, Jie, Yan, Kai, Lian, Zhe-Xiong

“…Macrophages are a critical component in host immune responses against tumor. In this work we investigated the role of forkhead box O1 (FoxO1) in the…”
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The challenges of primary biliary cholangitis: What is new and what needs to be done by Terziroli Beretta-Piccoli, Benedetta, Mieli-Vergani, Giorgina, Vergani, Diego, Vierling, John M., Adams, David, Alpini, Gianfranco, Banales, Jesus M., Beuers, Ulrich, Björnsson, Einar, Bowlus, Christopher, Carbone, Marco, Chazouillères, Olivier, Dalekos, George, De Gottardi, Andrea, Harada, Kenichi, Hirschfield, Gideon, Invernizzi, Pietro, Jones, David, Krawitt, Edward, Lanzavecchia, Antonio, Lian, Zhe-Xiong, Ma, Xiong, Manns, Michael, Mavilio, Domenico, Quigley, Eamon MM, Sallusto, Federica, Shimoda, Shinji, Strazzabosco, Mario, Swain, Mark, Tanaka, Atsushi, Trauner, Michael, Tsuneyama, Koichi, Zigmond, Ehud, Gershwin, M. Eric

“…Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive…”
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