Search Results - "Lian, Kon Oi"

Stratification of follicular thyroid tumours using data‐independent acquisition proteomics and a comprehensive thyroid tissue spectral library by Sun, Yaoting, Li, Lu, Zhou, Yan, Ge, Weigang, Wang, He, Wu, Runxin, Liu, Wei, Chen, Hao, Xiao, Qi, Cai, Xue, Dong, Zhen, Zhang, Fangfei, Xiao, Junhong, Wang, Guangzhi, He, Yi, Gao, Jinlong, Kon, Oi Lian, Iyer, Narayanan Gopalakrishna, Guan, Haixia, Teng, Xiaodong, Zhu, Yi, Zhao, Yongfu, Guo, Tiannan

“…Thyroid nodules occur in about 60% of the population. A major challenge in thyroid nodule diagnosis is to distinguish between follicular adenoma (FA) and…”
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Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift by Park, Jung Eun, Dutta, Bamaprasad, Tse, Shun Wilford, Gupta, Nikhil, Tan, Chee Fan, Low, Jee Keem, Yeoh, Kheng Wei, Kon, Oi Lian, Tam, James P., Sze, Siu Kwan

“…Developing tumors rapidly outgrow their oxygen supply and are subject to hypoxia, which stimulates hypersecretion of tumor-derived exosomes that promote…”
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FAT10 Plays a Role in the Regulation of Chromosomal Stability by Ren, Jianwei, Kan, Alison, Leong, Siew Hong, Ooi, London L.P.J., Jeang, Kuan-Teh, Chong, Samuel S., Kon, Oi Lian, Lee, Caroline G.L.

“…Aneuploidy is a key process in tumorigenesis. Dysfunction of the mitotic spindle checkpoint proteins has been implicated as a cause of aneuploidy in cells. We…”
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Cryopreservation of Neurospheres Derived from Human Glioblastoma Multiforme by Chong, Yuk‐Kien, Toh, Tan‐Boon, Zaiden, Norazean, Poonepalli, Anuradha, Leong, Siew Hong, Ong, Catherine Ee Ling, Yu, Yiting, Tan, Patrick B., See, Siew‐Ju, Ng, Wai‐Hoe, Ng, Ivan, Hande, Manoor P., Kon, Oi Lian, Ang, Beng‐Ti, Tang, Carol

“…Cancer stem cells have been shown to initiate and sustain tumor growth. In many instances, clinical material is limited, compounded by a lack of methods to…”
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Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival by Leong, Siew Hong, Lwin, Kyaw Myo, Lee, Sze Sing, Ng, Wai Har, Ng, Kia Min, Tan, Soo Yong, Ng, Bee Ling, Carter, Nigel P., Tang, Carol, Lian Kon, Oi

“…Chromosomal rearrangements are common in cancer. More than 50% occur in common fragile sites and disrupt tumor suppressors. However, such rearrangements are…”
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Extracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR) by Gallart-Palau, Xavier, Serra, Aida, Wong, Andrew See Weng, Sandin, Sara, Lai, Mitchell K. P., Chen, Christopher P., Kon, Oi Lian, Sze, Siu Kwan

“…Extracellular vesicles (EVs) such as exosomes and microvesicles mediate intercellular communication and regulate a diverse range of crucial biological…”
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Development of a liver‐specific Tet‐off AAV8 vector for improved safety of insulin gene therapy for diabetes by Gan, Shu Uin, Fu, Zhenying, Sia, Kian Chuan, Kon, Oi Lian, Calne, Roy, Lee, Kok Onn

“…Background Diabetes mellitus is caused by a partial or complete lack of insulin production in the body. We have previously shown that a single injection of an…”
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ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis by Chong, Yuk Kien, Sandanaraj, Edwin, Koh, Lynnette W H, Thangaveloo, Moogaambikai, Tan, Melanie S Y, Koh, Geraldene R H, Toh, Tan Boon, Lim, Grace G Y, Holbrook, Joanna D, Kon, Oi Lian, Nadarajah, Mahendran, Ng, Ivan, Ng, Wai Hoe, Tan, Nguan Soon, Lim, Kah Leong, Tang, Carol, Ang, Beng Ti

“…Cell surface sialylation is associated with tumor cell invasiveness in many cancers. Glioblastoma is the most malignant primary brain tumor and is highly…”
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One-Step Procedure for Peptide Extraction from In-Gel Digestion Sample for Mass Spectrometric Analysis by Meng, Wei, Zhang, Huoming, Guo, Tiannan, Pandey, Chhiti, Zhu, Yi, Kon, Oi Lian, Sze, Siu Kwan

“…Protein identification from samples resolved by one-dimensional and two-dimensional gel electrophoresis is highly dependent on the recovery of trypsin-digested…”
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Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene by Ganesan, Kumaresan, Ivanova, Tatiana, Wu, Yonghui, Rajasegaran, Vikneswari, Wu, Jeanie, Lee, Ming Hui, Yu, Kun, Rha, Sun Young, Chung, Hyun Cheol, Ylstra, Bauke, Meijer, Gerrit, Lian, Kon Oi, Grabsch, Heike, Tan, Patrick

“…Elevated expression of the PLA2G2A phospholipase in gastric cancer (GC) is associated with improved patient survival. To elucidate function and regulation of…”
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Artificial intelligence defines protein-based classification of thyroid nodules by Sun, Yaoting, Selvarajan, Sathiyamoorthy, Zang, Zelin, Liu, Wei, Zhu, Yi, Zhang, Hao, Chen, Wanyuan, Chen, Hao, Li, Lu, Cai, Xue, Gao, Huanhuan, Wu, Zhicheng, Zhao, Yongfu, Chen, Lirong, Teng, Xiaodong, Mantoo, Sangeeta, Lim, Tony Kiat-Hon, Hariraman, Bhuvaneswari, Yeow, Serene, Alkaff, Syed Muhammad Fahmy, Lee, Sze Sing, Ruan, Guan, Zhang, Qiushi, Zhu, Tiansheng, Hu, Yifan, Dong, Zhen, Ge, Weigang, Xiao, Qi, Wang, Weibin, Wang, Guangzhi, Xiao, Junhong, He, Yi, Wang, Zhihong, Sun, Wei, Qin, Yuan, Zhu, Jiang, Zheng, Xu, Wang, Linyan, Zheng, Xi, Xu, Kailun, Shao, Yingkuan, Zheng, Shu, Liu, Kexin, Aebersold, Ruedi, Guan, Haixia, Wu, Xiaohong, Luo, Dingcun, Tian, Wen, Li, Stan Ziqing, Kon, Oi Lian, Iyer, Narayanan Gopalakrishna, Guo, Tiannan

“…Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility of developing an…”
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A set of molecular markers predicts chemosensitivity to Mitomycin-C following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis by Shannon, Nicholas Brian, Tan, Joey Wee-Shan, Tan, Hwee Leong, Wang, Weining, Chen, Yudong, Lim, Hui Jun, Tan, Qiu Xuan, Hendrikson, Josephine, Ng, Wai Har, Loo, Li Yang, Skanthakumar, Thakshayeni, Wasudevan, Seettha D., Kon, Oi Lian, Lim, Tony Kiat Hon, Tan, Grace Hwei Ching, Chia, Claramae Shulyn, Soo, Khee Chee, Ong, Chin-Ann Johnny, Teo, Melissa Ching Ching

“…Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significant perioperative morbidity and mortality. We aim…”
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An Optimised Protocol Harnessing Laser Capture Microdissection for Transcriptomic Analysis on Matched Primary and Metastatic Colorectal Tumours by Ong, Chin-Ann J., Tan, Qiu Xuan, Lim, Hui Jun, Shannon, Nicholas B., Lim, Weng Khong, Hendrikson, Josephine, Ng, Wai Har, Tan, Joey W. S., Koh, Kelvin K. N., Wasudevan, Seettha D., Ng, Cedric C. Y., Rajasegaran, Vikneswari, Lim, Tony Kiat Hon, Ong, Choon Kiat, Kon, Oi Lian, Teh, Bin Tean, Tan, Grace H. C., Chia, Claramae Shulyn, Soo, Khee Chee, Teo, Melissa C. C.

“…Generation of large amounts of genomic data is now feasible and cost-effective with improvements in next generation sequencing (NGS) technology. Ribonucleic…”
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Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer by Hou, Qingsong, Wu, Yong Hui, Grabsch, Heike, Zhu, Yansong, Leong, Siew Hong, Ganesan, Kumaresan, Cross, Debra, Tan, Lay Keng, Tao, Jiong, Gopalakrishnan, Veena, Tang, Bor Luen, Kon, Oi Lian, Tan, Patrick

“…Recurrent genomic amplifications and deletions are frequently observed in primary gastric cancers (GC). However, identifying specific oncogenes and tumor…”
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Durable engraftment of genetically modified FVIII‐secreting autologous bone marrow stromal cells in the intramedullary microenvironment by Lee, Sze Sing, Sivalingam, Jaichandran, Nirmal, Ajit J., Ng, Wai Har, Kee, Irene, Song, In Chin, Kiong, Chin Yong, Gales, Kristoffer A., Chua, Frederic, Pena, Edgar M., Ogden, Bryan E., Kon, Oi Lian

“…Genetically modified FVIII‐expressing autologous bone marrow‐derived mesenchymal stromal cells (BMSCs) could cure haemophilia A. However, culture‐expanded…”
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Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors by Tan, Qiu Xuan, Shannon, Nicholas B, Lim, Weng Khong, Teo, Jing Xian, Yap, Daniel R Y, Lek, Sze Min, Tan, Joey W S, Tan, Shih Jia J, Hendrikson, Josephine, Liu, Ying, Ng, Gillian, Chong, Clara Y L, Guo, Wanyu, Koh, Kelvin K N, Ng, Cedric C Y, Rajasegaran, Vikneswari, Wong, Jolene S M, Seo, Chin Jin, Ong, Choon Kiat, Lim, Tony K H, Teh, Bin Tean, Kon, Oi Lian, Chia, Claramae S, Soo, Khee Chee, Iyer, N Gopalakrishna, Ong, Chin-Ann J

“…Field cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that…”
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Author Correction: Artificial intelligence defines protein-based classification of thyroid nodules by Sun, Yaoting, Selvarajan, Sathiyamoorthy, Zang, Zelin, Liu, Wei, Zhu, Yi, Zhang, Hao, Chen, Wanyuan, Chen, Hao, Li, Lu, Cai, Xue, Gao, Huanhuan, Wu, Zhicheng, Zhao, Yongfu, Chen, Lirong, Teng, Xiaodong, Mantoo, Sangeeta, Lim, Tony Kiat-Hon, Hariraman, Bhuvaneswari, Yeow, Serene, Alkaff, Syed Muhammad Fahmy, Lee, Sze Sing, Ruan, Guan, Zhang, Qiushi, Zhu, Tiansheng, Hu, Yifan, Dong, Zhen, Ge, Weigang, Xiao, Qi, Wang, Weibin, Wang, Guangzhi, Xiao, Junhong, He, Yi, Wang, Zhihong, Sun, Wei, Qin, Yuan, Zhu, Jiang, Zheng, Xu, Wang, Linyan, Zheng, Xi, Xu, Kailun, Shao, Yingkuan, Zheng, Shu, Liu, Kexin, Aebersold, Ruedi, Guan, Haixia, Wu, Xiaohong, Luo, Dingcun, Tian, Wen, Li, Stan Ziqing, Kon, Oi Lian, Iyer, Narayanan Gopalakrishna, Guo, Tiannan

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Characterization of Insulin-Secreting Porcine Bone Marrow Stromal Cells Ex Vivo and Autologous Cell Therapy In Vivo by Do, Hai Van Thi, Loke, Wan Ting, Kee, Irene, Liang, Vivienne, David, Sebastian J, Gan, Shu Uin, Lee, Sze Sing, Ng, Wai Har, Koong, Heng Nung, Ong, Hock Soo, Lee, Kok Onn, Calne, Roy Y, Kon, Oi Lian

“…Cell therapy could potentially meet the need for pancreas and islet transplantations in diabetes mellitus that far exceeds the number of available donors. Bone…”
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Human liver-derived cells stably modified for regulated proinsulin secretion function as bioimplants in vivo by Chen, Xiang, Patil, Jawahar G., Lok, Serene H. L., Lian Kon, Oi

“…Background Insulin deficiency is currently treated with pharmacological insulin secretagogues, insulin injections or islet transplants. Secondary failure of…”
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Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model by Chen, Nelson K F, Wong, Jen San, Kee, Irene H C, Lai, Siang Hui, Thng, Choon Hua, Ng, Wai Har, Ng, Robert T H, Tan, Soo Yong, Lee, Shu Yen, Tan, Mark E H, Sivalingam, Jaichandran, Chow, Pierce K H, Kon, Oi Lian

“…Current gene- and cell-based therapies have significant limitations which impede widespread clinical application. Taking diabetes mellitus as a paradigm, we…”
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