Search Results - "Lian, B J"

Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions by Akech, J, Wixted, J J, Bedard, K, van der Deen, M, Hussain, S, Guise, T A, van Wijnen, A J, Stein, J L, Languino, L R, Altieri, D C, Pratap, J, Keller, E, Stein, G S, Lian, J B

“…Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly metastatic prostate cancer cells. Here, we identified the functional…”
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Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance by Browne, G, Nesbitt, H, Ming, L, Stein, G S, Lian, J B, McKeown, S R, Worthington, J

“…Background: We have previously shown that hypoxia selects for more invasive, apoptosis-resistant LNCaP prostate cancer cells, with upregulation of the…”
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Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease by Kang, B H, Tavecchio, M, Goel, H L, Hsieh, C-C, Garlick, D S, Raskett, C M, Lian, J B, Stein, G S, Languino, L R, Altieri, D C

“…Background: The molecular chaperone heat shock protein-90 (Hsp90) is a promising cancer drug target, but current Hsp90-based therapy has so far shown limited…”
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Gut-derived serotonin contributes to bone deficits in colitis by Lavoie, B., Roberts, J.A., Haag, M.M., Spohn, S.N., Margolis, K.G., Sharkey, K.A., Lian, J.B., Mawe, G.M.

“…[Display omitted] Osteoporosis and bone fractures occur at higher frequency in patients with inflammatory bowel disease (IBD), and decreased bone mass is…”
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Transcriptional control of osteoblast growth and differentiation by Stein, G S, Lian, J B, Stein, J L, Van Wijnen, A J, Montecino, M

“…Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the…”
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Stage-Specific Expression of Dlx-5 during Osteoblast Differentiation: Involvement in Regulation of Osteocalcin Gene Expression by Ryoo, H. M, Hoffmann, H. M, Beumer, T, Frenkel, B, Towler, D. A, Stein, G. S, Stein, J. L, van Wijnen, A. J, Lian, J. B

“…Two homeotic genes, Dlx and Msx, appear to regulate development of mineralized tissues, including bone, cartilage, and tooth. Expression of Msx-1 and Msx-2 has…”
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Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells by BARNES, George L, JAVED, Amjad, STEIN, Gary S, GERSTENFELD, Louis C, WALLER, Sylvan M, KAMAL, Mohammad H, HEBERT, Kerri E, HASSAN, Mohammad Q, BELLAHCENE, Akeila, VAN WIJNEN, Andre J, YOUNG, Marian F, LIAN, Jane B

“…Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of…”
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Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone by Hauschka, P V, Lian, J B, Cole, D E, Gundberg, C M

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runt Homology Domain Transcription Factors (Runx, Cbfa, and AML) Mediate Repression of the Bone Sialoprotein Promoter: Evidence for Promoter Context-Dependent Activity of Cbfa Proteins by Javed, Amjad, Barnes, George L., Jasanya, B. O., Stein, Janet L., Gerstenfeld, Louis, Lian, Jane B., Stein, Gary S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene by Zaidi, S K, Javed, A, Choi, J Y, van Wijnen, A J, Stein, J L, Lian, J B, Stein, G S

“…Key components of DNA replication and the basal transcriptional machinery as well as several tissue-specific transcription factors are compartmentalized in…”
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Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation by McCabe, L R, Banerjee, C, Kundu, R, Harrison, R J, Dobner, P R, Stein, J L, Lian, J B, Stein, G S

“…Developmental studies of oncogene expression implicate the Fos and Jun family of transcription factors in the regulation of bone growth and differentiation…”
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Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone by Pratap, J, Lian, J B, Javed, A, Barnes, G L, van Wijnen, A J, Stein, J L, Stein, G S

“…The three mammalian Runt homology domain transcription factors (Runx1, Runx2, Runx3) support biological control by functioning as master regulatory genes for…”
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DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo by Isaac, J, Erthal, J, Gordon, J, Duverger, O, Sun, H-W, Lichtler, A C, Stein, G S, Lian, J B, Morasso, M I

“…Human mutations and in vitro studies indicate that DLX3 has a crucial function in bone development, however, the in vivo role of DLX3 in endochondral…”
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Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells by Aronow, M A, Gerstenfeld, L C, Owen, T A, Tassinari, M S, Stein, G S, Lian, J B

“…Rat calvaria osteoblasts derived from 21-day-old fetal rat pups undergo a temporal expression of markers of the osteoblast phenotype during a 5 week culture…”
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Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation by Stein, G S, Lian, J B, Owen, T A

“…The relationship of cell proliferation to the temporal expression of genes characterizing a developmental sequence associated with bone cell differentiation…”
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Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes by Shalhoub, V, Conlon, D, Tassinari, M, Quinn, C, Partridge, N, Stein, G S, Lian, J B

“…To understand the mechanisms by which glucocorticoids promote differentiation of fetal rat calvaria derived osteoblasts to produce bone-like mineralized…”
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Nuclear structure-gene expression interrelationships : Implications for aberrant gene expression in cancer by STEIN, G. S, MONTECINO, M, VAN WIJNEN, A. J, STEIN, J. L, LIAN, J. B

“…There is long-standing recognition that transformed and tumor cells exhibit striking alterations in nuclear morphology as well as in the representation and…”
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Osteocalcin. Biochemical considerations and clinical applications by Lian, J B, Gundberg, C M

“…The vitamin K-dependent protein of bone, osteocalcin (bone Gla protein) is a specific product of the osteoblast. A small fraction of that synthesized does not…”
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Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer by Fritz, A.J., Gillis, N.E., Gerrard, D.L., Rodriguez, P.D., Hong, D., Rose, J.T., Ghule, P.N., Bolf, E.L., Gordon, J.A., Tye, C.E., Boyd, J.R., Tracy, K.M., Nickerson, J.A., Wijnen, A.J., Imbalzano, A.N., Heath, J.L., Frietze, S.E., Zaidi, S.K., Carr, F.E., Lian, J.B., Stein, J.L., Stein, G.S.

“…Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this…”
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A Runx2 threshold for the cleidocranial dysplasia phenotype by Lou, Yang, Javed, Amjad, Hussain, Sadiq, Colby, Jennifer, Frederick, Dana, Pratap, Jitesh, Xie, Ronglin, Gaur, Tripti, van Wijnen, Andre J., Jones, Stephen N., Stein, Gary S., Lian, Jane B., Stein, Janet L.

“…Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2…”
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