Search Results - "Liam Lee"

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival by Lee, Chih-Shia, Lee, Liam C., Yuan, Tina L., Chakka, Sirisha, Fellmann, Christof, Lowe, Scott W., Caplen, Natasha J., McCormick, Frank, Luo, Ji

“…Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors…”
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Development of siRNA payloads to target KRAS-mutant cancer by Yuan, Tina L, Fellmann, Christof, Lee, Chih-Shia, Ritchie, Cayde D, Thapar, Vishal, Lee, Liam C, Hsu, Dennis J, Grace, Danielle, Carver, Joseph O, Zuber, Johannes, Luo, Ji, McCormick, Frank, Lowe, Scott W

“…RNAi is a powerful tool for target identification and can lead to novel therapies for pharmacologically intractable targets such as KRAS. RNAi therapy must…”
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CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance by Park, Kang-Seo, Raffeld, Mark, Moon, Yong Wha, Xi, Liqiang, Bianco, Caterina, Pham, Trung, Lee, Liam C, Mitsudomi, Tetsuya, Yatabe, Yasushi, Okamoto, Isamu, Subramaniam, Deepa, Mok, Tony, Rosell, Rafael, Luo, Ji, Salomon, David S, Wang, Yisong, Giaccone, Giuseppe

“…The majority of non-small cell lung cancer (NSCLC) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase…”
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The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status by Trigg, Ricky M., Lee, Liam C., Prokoph, Nina, Jahangiri, Leila, Reynolds, C. Patrick, Amos Burke, G. A., Probst, Nicola A., Han, Miaojun, Matthews, Jamie D., Lim, Hong Kai, Manners, Eleanor, Martinez, Sonia, Pastor, Joaquin, Blanco-Aparicio, Carmen, Merkel, Olaf, de los Fayos Alonso, Ines Garces, Kodajova, Petra, Tangermann, Simone, Högler, Sandra, Luo, Ji, Kenner, Lukas, Turner, Suzanne D.

“…Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired…”
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Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma by Pucci, Perla, Lee, Liam C., Han, Miaojun, Matthews, Jamie D., Jahangiri, Leila, Schlederer, Michaela, Manners, Eleanor, Sorby-Adams, Annabel, Kaggie, Joshua, Trigg, Ricky M., Steel, Christopher, Hare, Lucy, James, Emily R., Prokoph, Nina, Ducray, Stephen P., Merkel, Olaf, Rifatbegovic, Firkret, Luo, Ji, Taschner-Mandl, Sabine, Kenner, Lukas, Burke, G. A. Amos, Turner, Suzanne D.

“…Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK -expressing malignancies including neuroblastoma, but…”
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Biomarker Testing Journey Among Patients with Advanced Solid Tumors and Treatment Patterns by Homologous Recombination Repair Status: A Clinico-Genomic Database Study by Shao, Changxia, Ren, Yixin, Zhou, Heng, Lee, Liam C., Chen, Cai, Dettman, Elisha J., Cristescu, Razvan, Gozman, Alexander, Jin, Fan, Zhou, Wei

“…Introduction Defects in the homologous recombination repair (HRR) pathway can include mutations in BRCA1 and BRCA2 (BRCAm) and other HRR genes (HRRm). These…”
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Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9 by Yu, Bing, Swatkoski, Stephen, Holly, Alesia, Lee, Liam C., Giroux, Valentin, Lee, Chih-Shia, Hsu, Dennis, Jordan, L. Smith, Yuen, Garmen, Yue, Junqiu, Ann, David K., Simpson, R. Mark, Creighton, Chad J., Figg, William D., Gucek, Marjan, Luo, Ji

“…Significance Currently there are no targeted therapies for KRAS mutant cancer. Our study uncovers a critical role of the small ubiquitin-like modifier (SUMO)…”
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IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma by Prokoph, Nina, Probst, Nicola A., Lee, Liam C., Monahan, Jack M., Matthews, Jamie D., Liang, Huan-Chang, Bahnsen, Klaas, Montes-Mojarro, Ivonne A., Karaca-Atabay, Elif, Sharma, Geeta G., Malik, Vikas, Larose, Hugo, Forde, Sorcha D., Ducray, Stephen P., Lobello, Cosimo, Wang, Qi, Luan, Shi-Lu, Pospíšilová, Šárka, Gambacorti-Passerini, Carlo, Burke, G. A. Amos, Pervez, Shahid, Attarbaschi, Andishe, Janíková, Andrea, Pacquement, Hélène, Landman-Parker, Judith, Lambilliotte, Anne, Schleiermacher, Gudrun, Klapper, Wolfram, Jauch, Ralf, Woessmann, Wilhelm, Vassal, Gilles, Kenner, Lukas, Merkel, Olaf, Mologni, Luca, Chiarle, Roberto, Brugières, Laurence, Geoerger, Birgit, Barbieri, Isaia, Turner, Suzanne D.

“…Anaplastic large cell lymphoma (ALCL) is a T-cell malignancy predominantly driven by a hyperactive anaplastic lymphoma kinase (ALK) fusion protein. ALK…”
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Paediatric Burkitt lymphoma patient‐derived xenografts capture disease characteristics over time and are a model for therapy by Forde, Sorcha, Matthews, Jamie D., Jahangiri, Leila, Lee, Liam C., Prokoph, Nina, Malcolm, Tim I.M., Giger, Olivier T., Bell, Natalie, Blair, Helen, O'Marcaigh, Aengus, Smith, Owen, Kenner, Lukas, Bomken, Simon, Burke, Gladstone A. A., Turner, Suzanne D.

“…Summary Burkitt lymphoma (BL) accounts for almost two‐thirds of all B‐cell non‐Hodgkin lymphoma (B‐NHL) in children and adolescents and is characterised by a…”
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Association Between Homologous Recombination Repair Biomarkers and Survival in Patients With Solid Tumors by Shao, Changxia, Ren, Yixin, Zhou, Heng, Chen, Cai, Dettman, Elisha J, Lee, Liam C, Cristescu, Razvan, Gozman, Alexander, Jin, Fan, Zhou, Wei

“…Mutations in and/or (BRCAm), other homologous recombination repair genes (HRRm), and homologous recombination deficiency (HRD) lead to an accumulation of…”
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Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation by Ulferts, Rachel, Marcassa, Elena, Timimi, Lewis, Lee, Liam Changwoo, Daley, Andrew, Montaner, Beatriz, Turner, Suzanne Dawn, Florey, Oliver, Baillie, John Kenneth, Beale, Rupert

“…Although commonly associated with autophagosomes, LC3 can also be recruited to membranes by covalent lipidation in a variety of non-canonical contexts. These…”
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Understanding the performance and reliability of NLP tools: a comparison of four NLP tools predicting stroke phenotypes in radiology reports by Casey, Arlene, Davidson, Emma, Grover, Claire, Tobin, Richard, Grivas, Andreas, Zhang, Huayu, Schrempf, Patrick, O'Neil, Alison Q, Lee, Liam, Walsh, Michael, Pellie, Freya, Ferguson, Karen, Cvoro, Vera, Wu, Honghan, Whalley, Heather, Mair, Grant, Whiteley, William, Alex, Beatrice

“…Natural language processing (NLP) has the potential to automate the reading of radiology reports, but there is a need to demonstrate that NLP methods are…”
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One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation by Smith, Jordan L, Lee, Liam C, Read, Abigail, Li, Qiuning, Yu, Bing, Lee, Chih-Shia, Luo, Ji

“…The ability to transform normal human cells into cancer cells with the introduction of defined genetic alterations is a valuable method for understanding the…”
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Differential Effector Engagement by Oncogenic KRAS by Yuan, Tina L., Amzallag, Arnaud, Bagni, Rachel, Yi, Ming, Afghani, Shervin, Burgan, William, Fer, Nicole, Strathern, Leslie A., Powell, Katie, Smith, Brian, Waters, Andrew M., Drubin, David, Thomson, Ty, Liao, Rosy, Greninger, Patricia, Stein, Giovanna T., Murchie, Ellen, Cortez, Eliane, Egan, Regina K., Procter, Lauren, Bess, Matthew, Cheng, Kwong Tai, Lee, Chih-Shia, Lee, Liam Changwoo, Fellmann, Christof, Stephens, Robert, Luo, Ji, Lowe, Scott W., Benes, Cyril H., McCormick, Frank

“…KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3′ kinase,…”
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Impact of olfactory disorders on personal safety and well-being: a cross-sectional observational study by Lee, Liam, Luke, Louis, Boak, Duncan, Philpott, Carl

“…Objectives Investigate safety perceptions, quantify hazardous events, and analyse their manifestations in individuals with olfactory dysfunction through an…”
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Physician-reported barriers and strategies to using tumor mutational burden (TMB) testing in oncology care: An interview based study by Jones, Gieira S, Szamreta, Elizabeth A., Lee, Liam, Iyer, Radhika, Jackson, Bianca, Ning, Ning, Stephens, Jennifer, Hussain, Arif

“…e15063 Background: Despite the availability of genomic technologies to inform treatment for oncology patients, widespread adoption of genomic testing in the…”
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Phenotypic differences related to homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) treated in routine care settings in the United States (US) by Sillah, Arthur, Adeboyeje, Gboyega, Lee, Liam, Gart, Mike, Saunders, William M., Wang, Brandon, Dave, Poras, English, Sandy, Blanc, Simon

“…e17047 Background: Recent evidence suggests mutations in HRR genes predict clinical benefit from treatment with PARP inhibitors in patients (pts) with mCRPC…”
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Assessing the role of vascular risk factors in dementia: Mendelian randomization meta-analysis and comparison with observational estimates [version 1; peer review: 1 approved] by Lee, Liam, Walker, Rosie, Whiteley, William

“…Background:  Although observational studies demonstrate that higher levels of vascular risk factors are associated with an increased risk of dementia, these…”
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Plan for Developing a Cost-Effective and Sustainable Sago Machine to Increase Productivity and Ingenuity by Iniovaine Lekakali, Reichi Taniyaola, Liam Lee, Ora Renagi, Aezeden Mohamed

“…This paper describes the creativity, design, and construction of a customized sago machine with a kneading pipe, filter, storage tank, and shredder. The main…”
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Investigations and Outcomes for Olfactory Disorders by Luke, Louis, Lee, Liam, Jegatheeswaran, Lavandan, Philpott, Carl

“…Purpose of Review To provide a detailed overview of the investigations and core outcome measures for olfactory disorders. Recent Findings Olfactory disorders…”
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