Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet

•Coffee is one of the most widely consumed beverages in the Western world.•Coffee intake has been associated with reduced risk of many chronic diseases, including cardiovascular disease.•Green coffee bean extract did not protect against features of the metabolic syndrome in mice fed a high-fat diet....

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Published in:	Archives of biochemistry and biophysics Vol. 559; pp. 46 - 52
Main Authors:	Li Kwok Cheong, J.D., Croft, K.D., Henry, P.D., Matthews, V., Hodgson, J.M., Ward, N.C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-10-2014
Subjects:	Animals Aorta, Abdominal - drug effects Aorta, Abdominal - physiopathology Atherosclerosis Body Weight - drug effects Chlorogenic acid Coffee Coffee - chemistry Diet, High-Fat - adverse effects Endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Glucose Tolerance Test Insulin Resistance Male Metabolic syndrome Metabolic Syndrome - drug therapy Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Mice Mice, Inbred C57BL Oxidative Stress - drug effects Polyphenols - isolation & purification Polyphenols - pharmacology Polyphenols - therapeutic use Vasodilation - drug effects Endothelial dysfunction Chlorogenic acid Metabolic syndrome Coffee Atherosclerosis
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Summary:	•Coffee is one of the most widely consumed beverages in the Western world.•Coffee intake has been associated with reduced risk of many chronic diseases, including cardiovascular disease.•Green coffee bean extract did not protect against features of the metabolic syndrome in mice fed a high-fat diet. We have investigated the effects of the major polyphenol in coffee, chlorogenic acid (CGA), on obesity, glucose intolerance, insulin resistance, systemic oxidative stress and endothelial dysfunction in a mouse model of the metabolic syndrome. Thirty C57BL6 mice were randomly divided into (n=10/group) (i) normal diet (ND), (ii) high fat diet (HFD), or (iii) high fat diet supplemented with 0.5% w/w green coffee bean extract (GCE) rich in chlorogenic acid (HFD+GCE). The high fat diet consisted of 28% fat and all animals were maintained on their diets for 12weeks. The mice fed a HFD and HFD+GCE displayed symptoms of the metabolic syndrome compared to their normal fed counterparts, although no endothelial dysfunction was detected in the abdominal aortas after 12weeks. GCE did not attenuate HFD-induced obesity, glucose intolerance, insulin resistance or systemic oxidative stress. Furthermore, GCE did not protect against ex vivo oxidant (hypochlorous acid)-induced endothelial dysfunction.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-9861 1096-0384
DOI:	10.1016/j.abb.2014.02.005