Search Results - "Liére, P"

Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors by Schumacher, M, Mattern, C, Ghoumari, A, Oudinet, J P, Liere, P, Labombarda, F, Sitruk-Ware, R, De Nicola, A F, Guennoun, R

“…Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone…”
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Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection by Guennoun, R., Labombarda, F., Gonzalez Deniselle, M.C., Liere, P., De Nicola, A.F., Schumacher, M.

“…•Multiple receptors contribute to the progesterone effects.•Progesterone and allopregnanolone are neuroprotective.•Local biosynthesis of neurosteroids…”
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Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and stroke by Gaignard, P., Fréchou, M., Liere, P., Thérond, P., Schumacher, M., Slama, A., Guennoun, R.

“…Steroids are neuroprotective and a growing body of evidence indicates that mitochondria are a potential target of their effects. The mitochondria are the site…”
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P.2.b.013 Social isolation and "depressed" Flinders Sensitive Line rats: behaviour, steroids, and neuronal plasticity markers by Bianchi, M, Ladurelle, N, Liére, P, Pianos, A, Mathé, A.A, Baulieu, E.E

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Steroid Profiling in Brain and Plasma of Male and Pseudopregnant Female Rats after Traumatic Brain Injury: Analysis by Gas Chromatography/Mass Spectrometry by Meffre, D, Pianos, A, Liere, P, Eychenne, B, Cambourg, A, Schumacher, M, Stein, D. G, Guennoun, R

“…Steroids in brain arise from the peripheral endocrine glands and local synthesis. In traumatic brain injury (TBI), the endogenous circulating hormones at the…”
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Steroidome and metabolome analysis in gilt saliva to identify potential biomarkers of boar effect receptivity by Goudet, G., Prunier, A., Nadal-Desbarats, L., Grivault, D., Ferchaud, S., Pianos, A., Haddad, L., Montigny, F., Douet, C., Savoie, J., Maupertuis, F., Roinsard, A., Boulot, S., Liere, P.

“…Optimal management of gilt reproduction requires oestrus synchronization. Hormonal treatments are used for this purpose, but there is a growing demand for…”
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Injury Elicited Increase in Spinal Cord Neurosteroid Content Analyzed by Gas Chromatography Mass Spectrometry by Labombarda, F, Pianos, A, Liere, P, Eychenne, B, Gonzalez, S, Cambourg, A, De Nicola, A. F, Schumacher, M, Guennoun, R

“…The effects of spinal cord injury (SCI), combined with castration and adrenalectomy, and of progesterone (PROG) treatment on neurosteroid levels and…”
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Steroid hormones and neurosteroids in normal and pathological aging of the nervous system by Schumacher, M, Weill-Engerer, S, Liere, P, Robert, F, Franklin, R J M, Garcia-Segura, L M, Lambert, J J, Mayo, W, Melcangi, R C, Parducz, A, Suter, U, Carelli, C, Baulieu, E E, Akwa, Y

“…Without medical progress, dementing diseases such as Alzheimer's disease will become one of the main causes of disability. Preventing or delaying them has thus…”
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Pregnenolone sulfate in the brain: A controversial neurosteroid by Schumacher, Michael, Liere, Philippe, Akwa, Yvette, Rajkowski, Krzysztof, Griffiths, William, Bodin, Karl, Sjövall, Jan, Baulieu, Etienne-Emile

“…Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic…”
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The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain by Verleye, Marc, Akwa, Yvette, Liere, Philippe, Ladurelle, Nathalie, Pianos, Antoine, Eychenne, Bernard, Schumacher, Michael, Gillardin, Jean-Marie

“…The peripheral benzodiazepine receptors (PBR) might be involved in certain pathophysiological events, such as anxiety, by stimulating the production of…”
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SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair by Ferzaz, Badia, Brault, Emmanuel, Bourliaud, Genevieve, Robert, Jean-Pierre, Poughon, Gilles, Claustre, Yves, Marguet, Franck, Liere, Philippe, Schumacher, Michael, Nowicki, Jean-Pierre, Fournier, Jacqueline, Marabout, Benoit, Sevrin, Mireille, George, Pascal, Soubrie, Philippe, Benavides, Jesus, Scatton, Bernard

“…In the present study, we have investigated the potential neuroprotective effects of a novel peripheral benzodiazepine binding site (PBR) ligand,…”
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Mutation of palmitoylation site of Estrogen Receptor ER alpha in vivo reveals tissue-specific roles for membrane versus genomic effects of estrogens by Adlanmerini, M, Solinhac, R, Abot, A, Fabre, A, Raymond-Letron, I, Boudou, F, Kim, S.H, Lière, P, Fontaine, C, Krust, A, Chambon, P, Katzenellenbogen, J.A, Gourdy, P, Shaul, P.W, Henrion, D, Arnal, J.F, Lenfant, F

“…Introduction Estradiol (E2) binds to Estrogen Receptor alpha (ERα) activation functions (AF-1 and -2) and regulates gene transcription. A fraction of ERa is…”
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S.24.03 Neuroactive steroids as enhancers of neuroregeneration by Schumacher, M, Labombarda, F, Liere, P, De Nicola, A.F, Guennoun, R

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Characterization and regulation of the 3β‐hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve by Coirini, H., Gouézou, M., Delespierre, B., Liere, P., Pianos, A., Eychenne, B., Schumacher, M., Guennoun, R.

“…In the peripheral nervous system, progesterone (PROG) has a stimulatory effect on myelination. It could be derived from local synthesis, as Schwann cells in…”
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3β-Hydroxysteroid dehydrogenase expression in rat spinal cord by Coirini, H, Gouézou, M, Liere, P, Delespierre, B, Pianos, A, Eychenne, B, Schumacher, M, Guennoun, R

“…In adult male rats, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD) expressing cells were identified in the spinal cord from the cervical to the…”
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The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination by HUSSAIN, Rashad, GHOUMARI, Abdel M, TRONCHE, François, SITRUK-WARE, Regine, SCHUMACHER, Michael, SAID GHANDOUR, M, BIELECKI, Bartosz, STEIBEL, Jérôme, BOEHM, Nelly, LIERE, Philippe, MACKLIN, Wendy B, KUMAR, Narender, HABERT, René, MHAOUTY-KODJA, Sakina

“…Myelin regeneration is a major therapeutic goal in demyelinating diseases, and the failure to remyelinate rapidly has profound consequences for the health of…”
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Conditional Inactivation of Androgen Receptor Gene in the Nervous System: Effects on Male Behavioral and Neuroendocrine Responses by Raskin, Kalina, de Gendt, Karel, Duittoz, Anne, Liere, Philippe, Verhoeven, Guido, Tronche, Francois, Mhaouty-Kodja, Sakina

“…Testosterone (T) profoundly influences central sexual differentiation and functions. In the brain, T signals either directly through androgen receptor (AR) or…”
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Progesterone Receptors: A Key for Neuroprotection in Experimental Stroke by Liu, Ailing, Margaill, Isabelle, Zhang, Shaodong, Labombarda, Florencia, Coqueran, Bérard, Delespierre, Brigitte, Liere, Philippe, Marchand-Leroux, Catherine, O'Malley, Bert W, Lydon, John P, De Nicola, Alejandro F, Sitruk-Ware, Regine, Mattern, Claudia, Plotkine, Michel, Schumacher, Michael, Guennoun, Rachida

“…Progesterone receptors (PR) are expressed throughout the brain. However, their functional significance remains understudied. Here we report a novel role of PR…”
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Influence of ion activation and thermalization effects on reaction rate constants in a quadrupole ion trap mass spectrometer by Liere, P., Steiner, V., Jennings, K.R., March, R.E., Tabet, J.C.

“…The insertion of a ‘cooling’ time period following ionization in a quadruple ion trap mass spectrometer, so as to cool ion spatial and kinetic energy…”
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Influence of trapping parameters on ion injection and dissociation efficiencies in a quadrupole mass filter/ion trap tandem instrument by Steiner, V., Beaugrand, C., Liere, P., Tabet, J.-C.

“…Investigations on ion injection into a laboratory‐built quadrupole/ion trap tandem instrument (Nermag R10‐10/ITMS Finnigan) with a 90° geometry are described…”
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