Search Results - "Li, Zhangqiang"

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution by Shen, Huaizong, Zhou, Qiang, Pan, Xiaojing, Li, Zhangqiang, Wu, Jianping, Yan, Nieng

“…Voltage-gated sodium (Na ) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of…”
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Structure of the voltage-gated calcium channel Cav1.1 complex by Wu, Jianping, Yan, Zhen, Li, Zhangqiang, Yan, Chuangye, Lu, Shan, Dong, Mengqiu, Yan, Nieng

“…The voltage-gated calcium channel Ca(v)1.1 is engaged in the excitation-contraction coupling of skeletal muscles. The Ca(v)1.1 complex consists of the…”
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Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
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Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution by Wu, Jianping, Yan, Zhen, Li, Zhangqiang, Qian, Xingyang, Lu, Shan, Dong, Mengqiu, Zhou, Qiang, Yan, Nieng

“…The voltage-gated calcium (Ca v ) channels convert membrane electrical signals to intracellular Ca 2+ -mediated events. Among the ten subtypes of Ca v channel…”
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Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA by Pan Xiaojing, Li Zhangqiang, Huang Xiaoshuang, Huang Gaoxingyu, Gao Shuai, Shen Huaizong, Liu, Lei, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
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Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1 by Pan Xiaojing, Li Zhangqiang, Zhou, Qiang, Shen Huaizong, Wu, Kun, Huang Xiaoshuang, Chen Jiaofeng, Zhang Juanrong, Zhu Xuechen, Lei Jianlin, Xiong, Wei, Gong Haipeng, Xiao Bailong, Nieng, Yan

“…Structures of voltage-gated sodium channelsIn “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit…”
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The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening by Bai, Xiao-Chen, Yan, Zhen, Wu, Jianping, Li, Zhangqiang, Yan, Nieng

“…The ryanodine receptors （RyRs） are intracellular calcium channels responsible for rapid release of Ca^2＋ from the sarcoplasmic/endoplasmic reticulum （SR/ER） to…”
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Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine by Li, Zhangqiang, Jin, Xueqin, Wu, Tong, Huang, Gaoxingyu, Wu, Kun, Lei, Jianlin, Pan, Xiaojing, Yan, Nieng

“…Nav1.5, the primary voltage‐gated Na+ (Nav) channel in heart, is a major target for class I antiarrhythmic agents. Here we present the cryo‐EM structure of…”
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Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome by Li, Zhangqiang, Jin, Xueqin, Wu, Tong, Zhao, Xin, Wang, Weipeng, Lei, Jianlin, Pan, Xiaojing, Yan, Nieng

“…Nav1.5 is the primary voltage-gated Na⁺ (Nav) channel in the heart. Mutations of Nav1.5 are associated with various cardiac disorders exemplified by the type 3…”
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A structural atlas of druggable sites on Nav channels by Li, Zhangqiang, Wu, Qiurong, Yan, Nieng

“…Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological…”
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Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution by Yan, Zhen, Bai, Xiao-chen, Yan, Chuangye, Wu, Jianping, Li, Zhangqiang, Xie, Tian, Peng, Wei, Yin, Chang-cheng, Li, Xueming, Scheres, Sjors H. W., Shi, Yigong, Yan, Nieng

“…The ryanodine receptors (RyRs) are high-conductance intracellular Ca 2+ channels that play a pivotal role in the excitation–contraction coupling of skeletal…”
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Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies by Pan, Xiaojing, Li, Zhangqiang, Jin, Xueqin, Zhao, Yanyu, Huang, Gaoxingyu, Huang, Xiaoshuang, Shen, Zilin, Cao, Yong, Dong, Mengqiu, Lei, Jianlin, Yan, Nieng

“…Among the nine subtypes of human voltage-gated sodium (Nav) channels, the brain and cardiac isoforms, Nav1.1 and Nav1.5, each carry more than 400 missense…”
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A Review of Top‐Down Strategies for the Production of Quantum‐Sized Materials by Chen, Zhexue, Zhao, Ce, Zhou, Xuanping, Xiao, Liuyang, Li, Zhangqiang, Zhang, Yong

“…Nanoscience and technology have made significant achievements in the past few decades. Quantum‐sized materials, as a key component of nanomaterials, have…”
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A structural atlas of druggable sites on Na v channels by Li, Zhangqiang, Wu, Qiurong, Yan, Nieng

“…Voltage-gated sodium (Na ) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological…”
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Interaction with teichoic acids contributes to highly effective antibacterial activity of graphene oxide on Gram-positive bacteria by Wang, Meizhen, Li, Zhangqiang, Zhang, Yunyun, Li, Yue, Li, Na, Huang, Dan, Xu, Baile

“…Graphene oxide (GO) has high-efficient antibacterial activity to diverse pathogenic bacteria. However, the detailed antibacterial mechanism of GO is not fully…”
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Prevalence of fluoroquinolone, macrolide and sulfonamide-related resistance genes in landfills from East China, mainly driven by MGEs by Yao, Lihua, Li, Yue, Li, Zhangqiang, Shen, Dongsheng, Feng, Huajun, Zhou, Huihua, Wang, Meizhen

“…Landfills are one of the most important reservoirs of antibiotic resistance genes (ARGs), and ARG pollution in landfills has been well investigated. However,…”
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Size-dependent and support-enhanced electrocatalysis of 2H-MoS2 for hydrogen evolution by Chen, Zhexue, Chang, Jinquan, Liang, Cheng, Wang, Weibiao, Li, Yueqi, Li, Zhangqiang, Zhang, Yong

“…Both theoretical and experimental investigations have shown that two-dimensional (2D) materials present intriguing electrocatalytic activity due to their…”
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CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy by Wang, Tongtong, Li, Zhangqiang, Xu, Kui, Huang, Wenze, Huang, Gaoxingyu, Zhang, Qiangfeng Cliff, Yan, Nieng

“…Structural biology is experiencing a paradigm shift from targeted structural determination to structure-guided discovery of previously uncharacterized…”
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Platinum Nanoparticles Prevent the Resistance of Pseudomonas aeruginosa to Ciprofloxacin and Imipenem: Mechanism Insights by Zhou, Zhiruo, Lian, Yulu, Zhu, Lin, Zhang, Haibo, Li, Zhangqiang, Wang, Meizhen

“…Metal nanoparticles (MNPs) have recently gained extensive attention due to their broad-spectrum prospect, particularly in biomedical application. Here, we…”
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Dissection of the structure–function relationship of Nav channels by Li, Zhangqiang, Wu, Qiurong, Huang, Gaoxingyu, Jin, Xueqin, Li, Jiaao, Pan, Xiaojing, Yan, Nieng

“…Voltage-gated sodium channels (Nav) undergo conformational shifts in response to membrane potential changes, a mechanism known as the electromechanical…”
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