Search Results - "Li, Yun R"

Stress granules as crucibles of ALS pathogenesis by Li, Yun R, King, Oliver D, Shorter, James, Gitler, Aaron D

“…Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting primarily motor neurons. Two RNA-binding proteins, TDP-43 and FUS,…”
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Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations by Li, Yun R, Keating, Brendan J

“…Genome-wide association studies (GWASs) are the method most often used by geneticists to interrogate the human genome, and they provide a cost-effective way to…”
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The missense of smell: functional variability in the human odorant receptor repertoire by Mainland, Joel D, Keller, Andreas, Li, Yun R, Zhou, Ting, Trimmer, Casey, Snyder, Lindsey L, Moberly, Andrew H, Adipietro, Kaylin A, Liu, Wen Ling L, Zhuang, Hanyi, Zhan, Senmiao, Lee, Somin S, Lin, Abigail, Matsunami, Hiroaki

“…In this study, Mainland and colleagues de-orphan 18 human odorant receptors and find that 68% of these receptors exhibit polymorphisms that affect their…”
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Breast cancer subtype distribution is different in normal weight, overweight, and obese women by Gershuni, Victoria, Li, Yun R., Williams, Austin D., So, Alycia, Steel, Laura, Carrigan, Elena, Tchou, Julia

“…Purpose Obesity is associated with tumor promoting pathways related to insulin resistance and chronic low-grade inflammation which have been linked to various…”
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Genomic risk scores for juvenile idiopathic arthritis and its subtypes by Cánovas, Rodrigo, Cobb, Joanna, Brozynska, Marta, Bowes, John, Li, Yun R, Smith, Samantha Louise, Hakonarson, Hakon, Thomson, Wendy, Ellis, Justine A, Abraham, Gad, Munro, Jane E, Inouye, Michael

“…Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. Diagnosis of JIA is based purely on clinical…”
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Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma by Meng, Fan, Li, Tiane, Singh, Anup K., Wang, Yingying, Attiyeh, Marc, Kohram, Fatemeh, Feng, Qianhua, Li, Yun R., Shen, Binghui, Williams, Terence, Liu, Yilun, Raoof, Mustafa

“…Oncogenic mutations (such as in KRAS) can dysregulate transcription and replication, leading to transcription-replication conflicts (TRCs). Here, we…”
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Human olfactory receptor responses to odorants by Mainland, Joel D, Li, Yun R, Zhou, Ting, Liu, Wen Ling L, Matsunami, Hiroaki

“…Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by…”
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Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling by Elia, Josephine, Ungal, Grace, Kao, Charlly, Ambrosini, Alexander, De Jesus-Rosario, Nilsa, Larsen, Lene, Chiavacci, Rosetta, Wang, Tiancheng, Kurian, Christine, Titchen, Kanani, Sykes, Brian, Hwang, Sharon, Kumar, Bhumi, Potts, Jacqueline, Davis, Joshua, Malatack, Jeffrey, Slattery, Emma, Moorthy, Ganesh, Zuppa, Athena, Weller, Andrew, Byrne, Enda, Li, Yun R., Kraft, Walter K., Hakonarson, Hakon

“…The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind,…”
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Pan-Cancer Survival Classification With Clinicopathological and Targeted Gene Expression Features by Zhao, Daniel, Kim, Daniel Y, Chen, Peter, Yu, Patrick, Ho, Sophia, Cheng, Stephanie W, Zhao, Cindy, Guo, Jimmy A, Li, Yun R

“…Prognostication for patients with cancer is important for clinical planning and management, but remains challenging given the large number of factors that can…”
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Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations by Cyrus, Cyril, Al-Mueilo, Samir, Vatte, Chittibabu, Chathoth, Shahanas, Li, Yun R, Qutub, Hatem, Al Ali, Rudaynah, Al-Muhanna, Fahad, Lanktree, Matthew B, Alkharsah, Khaled Riyad, Al-Rubaish, Abdullah, Kim-Mozeleski, Brian, Keating, Brendan, Al Ali, Amein

“…Genome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular…”
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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS by Kim, Hong Joo, Kim, Nam Chul, Wang, Yong-Dong, Scarborough, Emily A., Moore, Jennifer, Diaz, Zamia, MacLea, Kyle S., Freibaum, Brian, Li, Songqing, Molliex, Amandine, Kanagaraj, Anderson P., Carter, Robert, Boylan, Kevin B., Wojtas, Aleksandra M., Rademakers, Rosa, Pinkus, Jack L., Greenberg, Steven A., Trojanowski, John Q., Traynor, Bryan J., Smith, Bradley N., Topp, Simon, Gkazi, Athina-Soragia, Miller, Jack, Shaw, Christopher E., Kottlors, Michael, Kirschner, Janbernd, Pestronk, Alan, Li, Yun R., Ford, Alice Flynn, Gitler, Aaron D., Benatar, Michael, King, Oliver D., Kimonis, Virginia E., Ross, Eric D., Weihl, Conrad C., Shorter, James, Taylor, J. Paul

“…Algorithms designed to identify canonical yeast prions predict that around 250 human proteins, including several RNA-binding proteins associated with…”
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Stampede to Cure by Li, Yun R., Roach, Mack

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An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection by Shaked, Abraham, Chang, Bao‐Li, Barnes, Michael R., Sayre, Peter, Li, Yun R., Asare, Smita, DesMarais, Michele, Holmes, Michael V., Guettouche, Toumy, Keating, Brendan J.

“…The ability to noninvasively diagnose acute cellular rejection (ACR) with high specificity and sensitivity would significantly advance personalized liver…”
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Understanding the genetic and epigenetic basis of common variable immunodeficiency disorder through omics approaches by Li, Jin, Wei, Zhi, Li, Yun R., Maggadottir, S. Melkorka, Chang, Xiao, Desai, Akshatha, Hakonarson, Hakon

“…Common variable immunodeficiency disorder (CVID) is the most frequently encountered symptomatic primary immunodeficiency, characterized by highly heterogeneous…”
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Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci by Tragante, Vinicius, Barnes, Michael R., Ganesh, Santhi K., Franceschini, Nora, Johnson, Toby, Karczewski, Konrad J., Almoguera, Berta, Barnard, John, Baumert, Jens, Chang, Yen-Pei Christy, Elbers, Clara C., Fischer, Mary E., Gaunt, Tom R., Gho, Johannes M.I.H., Gieger, Christian, Goel, Anuj, Gong, Yan, Kleber, Marcus E., Leach, Irene Mateo, McDonough, Caitrin W., Meijs, Matthijs F.L., Melander, Olle, Nolte, Ilja M., Pankratz, Nathan, Price, Tom S., Shah, Sonia, Tomaszewski, Maciej, van der Most, Peter J., Van Iperen, Erik P.A., Vonk, Judith M., Witkowska, Kate, Wong, Caroline O.L., Beitelshees, Amber L., Berenson, Gerald S., Brown, Morris, Cooper-DeHoff, Rhonda M., Connell, John M., Cruickshanks, Karen J., Davey-Smith, George, Delles, Christian, Gansevoort, Ron T., Guo, Xiuqing, Haiqing, Shen, Hastie, Claire E., Hofker, Marten H., Kim, Daniel S., Kirkland, Susan A., Klein, Barbara E., Klein, Ronald, Newton-Cheh, Christopher, O’Brien, Eoin T., Onland-Moret, N. Charlotte, Palmas, Walter, Parsa, Afshin, Penninx, Brenda W., Vasan, Ramachandran S., M Ridker, Paul, Rose, Lynda M., Sever, Peter, Shimbo, Daichi, Steele, Laura, Thorand, Barbara, Trip, Mieke D., van Duijn, Cornelia M., Wyatt, Sharon, Young, J. Hunter, Zwinderman, Aeilko H., Bezzina, Connie R., Boerwinkle, Eric, Casas, Juan P., Caulfield, Mark J., Chakravarti, Aravinda, Chasman, Daniel I., Doevendans, Pieter A., FitzGerald, Garret A., Fornage, Myriam, Hakonarson, Hakon, Halder, Indrani, Hillege, Hans L., Illig, Thomas, Johnson, Julie A., März, Winfried, O’Connell, Jeffery R., Oldehinkel, Albertine J., Pankow, James S., Rader, Daniel J., Reilly, Muredach P., Schadt, Eric E., Kottke-Marchant, Kandice, Snieder, Harold, Stanton, Alice V., Tobin, Martin D., Samani, Nilesh J., Watkins, Hugh, Johnson, Andrew D., Reiner, Alex P., Zhu, Xiaofeng, de Bakker, Paul I.W., Asselbergs, Folkert W., Munroe, Patricia B.

“…Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean…”
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Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review by Mercier, Benjamin D, Tizpa, Eemon, Philip, Errol J, Feng, Qianhua, Huang, Ziyi, Thomas, Reeny M, Pal, Sumanta K, Dorff, Tanya B, Li, Yun R

“…Chemotherapy and radiotherapy are first-line treatments in the management of advanced solid tumors. Whereas these treatments are directed at eliminating cancer…”
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Mesothelin expression is associated with poor outcomes in breast cancer by Li, Yun R., Xian, Rena R., Ziober, Amy, Conejo-Garcia, Jose, Perales-Puchalt, Alfredo, June, Carl H., Zhang, Paul J., Tchou, Julia

“…Mesothelin is a potential therapeutic target and prognostic marker in breast cancer. However, results on its prognostic value in breast cancer have been…”
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A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma by Rice, Stephanie R., Li, Yun R., Busch, Theresa M., Kim, Michele M., McNulty, Sally, Dimofte, Andrea, Zhu, Timothy C., Cengel, Keith A., Simone, Charles B.

“…Malignant pleural mesothelioma remains difficult to treat, with high failure rates despite optimal therapy. We present a novel prospective trial combining…”
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ANKRD11 variants: KBG syndrome and beyond by Parenti, Ilaria, Mallozzi, Mark B., Hüning, Irina, Gervasini, Cristina, Kuechler, Alma, Agolini, Emanuele, Albrecht, Beate, Baquero‐Montoya, Carolina, Bohring, Axel, Bramswig, Nuria C., Busche, Andreas, Dalski, Andreas, Guo, Yiran, Hanker, Britta, Hellenbroich, Yorck, Horn, Denise, Innes, A. Micheil, Leoni, Chiara, Li, Yun R., Lynch, Sally Ann, Mariani, Milena, Medne, Livija, Mikat, Barbara, Milani, Donatella, Onesimo, Roberta, Ortiz‐Gonzalez, Xilma, Prott, Eva Christina, Reutter, Heiko, Rossier, Eva, Selicorni, Angelo, Wieacker, Peter, Wilkens, Alisha, Wieczorek, Dagmar, Zackai, Elaine H., Zampino, Giuseppe, Zirn, Birgit, Hakonarson, Hakon, Deardorff, Matthew A., Gillessen‐Kaesbach, Gabriele, Kaiser, Frank J.

“…Mutations affecting the transcriptional regulator Ankyrin Repeat Domain 11 (ANKRD11) are mainly associated with the multisystem developmental disorder known as…”
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The impact of aspirin use on breast cancer subtype and clinical course by Williams, Austin D., Li, Yun R., So, Alycia, Steel, Laura, Carrigan, Elena, Ro, Vicky, Nguyen, Jenny, Tchou, Julia

“…The use of aspirin has been associated with improved survival in patients with breast cancer, but the results have been mixed. We aim to analyze the impact of…”
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