Search Results - "Li, Yinxiong"

COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment management by Li, Penghui, Liu, Ying, Cheng, Ziqi, Yu, Xiaorui, Li, Yinxiong

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global epidemic and poses a major…”
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A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes by Li, Qiuhong, Hutchins, Andrew P., Chen, Yong, Li, Shengbiao, Shan, Yongli, Liao, Baojian, Zheng, Dejin, Shi, Xi, Li, Yinxiong, Chan, Wai-Yee, Pan, Guangjin, Wei, Shicheng, Shu, Xiaodong, Pei, Duanqing

“…Reprogramming has been shown to involve EMT–MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to…”
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Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish by Zhao, Shaoyang, Xia, Jianhong, Wu, Xiuhua, Zhang, Leilei, Wang, Pengtao, Wang, Haiyun, Li, Heying, Wang, Xiaoshan, Chen, Yan, Agnetti, Jean, Li, Yinxiong, Pei, Duanqing, Shu, Xiaodong

“…The class III PI3-kinase (PIK3C3) is an enzyme responsible for the generation of phosphatidylinositol 3-phosphate (PI3P), a critical component of vesicular…”
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Transcriptome Analyses of Liver Sinusoidal Endothelial Cells Reveal a Consistent List of Candidate Genes Associated with Endothelial Dysfunction and the Fibrosis Progression by Li, Penghui, Xie, Wenjie, Wei, Hongjin, Yang, Fan, Chen, Yan, Li, Yinxiong

“…Liver fibrosis is an important step in the transformation of chronic liver disease into cirrhosis and liver cancer, and structural changes and functional…”
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Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site by Abbas, Nasir, You, Kai, Getachew, Anteneh, Wu, Feima, Hussain, Muzammal, Huang, Xinping, Chen, Yan, Pan, Tingcai, Li, Yinxiong

“…Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a…”
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Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle by Tao, Jiawang, Chen, Yan, Zhuang, Yuanqi, Wei, Ruzhi, Getachew, Anteneh, Pan, Tingcai, Yang, Fan, Li, Yinxiong

“…Liver regeneration is a complicated biological process orchestrated by various liver resident cells. Hepatic cell proliferation and reconstruction of the…”
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Generation of a TLR2 homozygous knockout human embryonic stem cell line WAe001-A-64 using CRISPR/Cas9 editing by Getachew, Anteneh, Yang, Zhen, Huang, Xinping, Wu, Feima, Liu, Yan Ying, Yan, Chen, Yang, Fan, Li, Yinxiong

“…Toll-like receptor 2 (TLR2) is a pattern recognition receptor which plays an important role in innate immune system. In humans it’s encoded by the TLR2 gene…”
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Smart Microneedle Arrays Integrating Cell‐Free Therapy and Nanocatalysis to Treat Liver Fibrosis by Xu, Yanteng, Zhang, Yixin, Tian, Hao, Zhong, Qingguo, Yi, Ke, Li, Fenfang, Xue, Tiantian, Wang, Haixia, Lao, Yeh‐Hsing, Xu, Yingying, Li, Yinxiong, Long, Ling, Li, Kai, Tao, Yu, Li, Mingqiang

“…Liver fibrosis is a chronic pathological condition lacking specific clinical treatments. Stem cells, with notable potential in regenerative medicine, offer…”
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HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6 by Yin, Menghui, Cheng, Meidie, Liu, Chengli, Wu, Keli, Xiong, Wei, Fang, Ji, Li, Yinxiong, Zhang, Biliang

“…The functional inactivation of tumor suppressor microRNA (miRNA) is closely related to the tumorigenesis of cancer. There are instances where the miRNA and the…”
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Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells by Sammad, Abdul, Ahmed, Tanveer, Ullah, Khair, Hu, Lirong, Luo, Hanpeng, Alphayo Kambey, Piniel, Faisal, Shah, Zhu, Huabin, Li, Yinxiong, Wang, Yachun

“…Heat stress-induced biochemical alterations in ovarian follicles compromise the function of granulosa cells (GCs) and the developmental competence of oocytes…”
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Where cell fate conversions meet Chinese philosophy by Zheng, Hui, Hutchins, Andrew Paul, Pan, Guangjin, Li, Yinxiong, Pei, Duanqing, Pei, Gang

“…Accumulating evidence indicates that the mesenehymal-epithelial transition （MET） and epithelial-mesenchymal transition （EMT） are basic mechanisms for cell fate…”
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SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury by Getachew, Anteneh, Abbas, Nasir, You, Kai, Yang, Zhen, Hussain, Muzammal, Huang, Xinping, Cheng, Ziqi, Tan, Shenglin, Tao, Jiawang, Yu, Xiaorui, Chen, Yan, Yang, Fan, Pan, Tingcai, Xu, Yingying, Xu, Guosheng, Zhuang, Yuanqi, Wu, FeiMa, Li, Yinxiong

“…Hepatic stellate cells (HSCs) are crucial for liver injury repair and cirrhosis. However, the mechanism of chemotactic recruitment of HSCs into injury loci is…”
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Retaining mTeSR1 Medium during Hepatic Differentiation Facilitates Hepatocyte-Like Cell Survival by Decreasing Apoptosis by Hou, Jian, Long, Yan, Hu, Bo, Huang, Shaojie, Xu, Guangtao, Gao, Tesheng, Wu, Fenfang, Li, Yinxiong, Wu, Zhong-Kai

“…Background/Aims: Hepatocyte-like cells derived from human pluripotent stem cells could be an important cell source for hepatocyte transplantation. The present…”
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A Cured Coronavirus Disease 2019 Case of an 86-Year-Old With 13 Chronic Diseases: A Case Report by Tu, Yanhong, Fang, Ji, Yin, Menghui, Yu, Weizhong, Li, Yinxiong

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Relationship between birth size and coronary heart disease in China by Fan, Zhongjie, Zhang, Zhen-Xin, Li, Yinxiong, Wang, Zishi, Xu, Tao, Gong, Xiaomin, Zhou, Xioaling, Wen, Hongbo, Zeng, Yi

“…Clinical epidemiological studies suggested a link between fetal growth conditions and later coronary heart disease (CHD) in adult life. However, no such…”
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Toll-like receptor 2 signaling in liver pathophysiology by Getachew, Anteneh, Hussain, Muzammal, Huang, Xinping, Li, Yinxiong

“…Chronic liver diseases (CLD) are among the major cause of mortality and morbidity worldwide. Despite current achievements in the area of hepatitis virus,…”
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Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury by You, Kai, Wang, Yan, Chen, Xiaoxia, Yang, Zhen, Chen, Yan, Tan, Shenglin, Tao, Jiawang, Getachew, Anteneh, Pan, Tingcai, Xu, Yingying, Zhuang, Yuanqi, Yang, Fan, Lin, Xianhua, Li, Yinxiong

“…Serum amyloid A (SAA) is an acute response protein that mainly produced by hepatocytes, and it can promote endothelial dysfunction via a pro-inflammatory and…”
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Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity by Xiong, Yue, Chen, Yan, Huang, Xinping, Yang, Zhen, Zhang, Jiaye, Yu, Xiaorui, Fang, Ji, Tao, Jiawang, You, Kai, Cheng, Ziqi, Tan, Shenglin, Xu, Yingying, Yuan, Fang, Liu, Ying, Zhuang, Yuanqi, Yang, Fan, Li, Yinxiong

“…This study aimed to reveal the effects of icaritin (ICT) on lipotoxicity induced by palmitate (PA) in hepatic cells and steatosis in high-fat diet (HFD)-fed…”
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Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors by Jiang, Zhiwu, Cheng, Lin, Wu, Zhiping, Zhou, Linfu, Wang, Haitao, Hong, Qilan, Wu, Qiting, Long, Youguo, Huang, Yunlin, Xu, Gaoqi, Yao, Yao, Tang, Zhaoyang, Zhang, Zhenfeng, Yang, Lili, Luo, Wei, Yang, Jie, Gong, Likun, Liu, Pentao, Chen, Xinwen, Cui, Shuzhong, Zhang, Qi, Li, Yinxiong, Li, Peng

“…Our understanding of human hepatocellular carcinoma (HCC) development and progression has been hampered by the lack of in vivo models. We performed a genetic…”
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Calcitriol promotes the maturation of hepatocyte-like cells derived from human pluripotent stem cells by Yuan, Fang, Wang, Ning, Chen, Yan, Huang, Xinping, Yang, Zhen, Xu, Yingying, You, Kai, Zhang, Jiaye, Wang, Guodong, Zhuang, Yuanqi, Pan, Tingcai, Xiong, Yue, Yu, Xiaorui, Yang, Fan, Li, Yinxiong

“…•Calcitriol promoted the functionalities of hPSCs-derived HLCs in P450 activity, urea production, and albumin secretion.•Calcitriol enhanced the mitochondrial…”
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