Search Results - "Li, Xiaoheng"

Drug Development for Alzheimer's Disease: Microglia Induced Neuroinflammation as a Target? by Dong, Yuan, Li, Xiaoheng, Cheng, Jinbo, Hou, Lin

“…Alzheimer's disease (AD) is one of the most common causes of dementia. Its pathogenesis is characterized by the aggregation of the amyloid-β (Aβ) protein in…”
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Toxicological Effects of Cadmium on Mammalian Testis by Zhu, Qiqi, Li, Xiaoheng, Ge, Ren-Shan

“…Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male…”
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Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells by Ye, Leping, Li, Xiaoheng, Li, Linxi, Chen, Haolin, Ge, Ren-Shan

“…Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to…”
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Cyclic cRGDfk peptide and Chlorin e6 functionalized silk fibroin nanoparticles for targeted drug delivery and photodynamic therapy by Mao, Baiping, Liu, Caixia, Zheng, Wenwen, Li, Xiaoheng, Ge, Renshan, Shen, Haifa, Guo, Xiaoling, Lian, Qingquan, Shen, Xian, Li, Chao

“…Regenerated silk fibroin (SF) is a natural biomacromolecule with excellent biocompatible and biodegradable properties. In this study, cyclic pentapeptide…”
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Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice by Li, Shuoshuo, Liao, Yajin, Dong, Yuan, Li, Xiaoheng, Li, Jun, Cheng, Yong, Cheng, Jinbo, Yuan, Zengqiang

“…Alteration of immune status in the central nervous system (CNS) has been implicated in the development of post-traumatic stress disorder (PTSD). However, the…”
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Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes by Li, Xiaoheng, Wang, Zhao, Jiang, Zhenming, Guo, Jingjing, Zhang, Yuxi, Li, Chenhao, Chung, Jinyong, Folmer, Janet, Liu, June, Lian, Qingquan, Ge, Renshan, Zirkin, Barry R., Chen, Haolin

“…Testicular Leydig cells are the primary source of testosterone in males. Adult Leydig cells have been shown to arise from stem cells present in the neonatal…”
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Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function by Yao, Rumeng, Pan, Ruiyuan, Shang, Chao, Li, Xiaoheng, Cheng, Jinbo, Xu, Jiangping, Li, Yunfeng

“…TSPO is mainly expressed in the mitochondrial outer membrane of microglia in the central nervous system, and its expression is greatly increased when microglia…”
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Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice by Dong, Yuan, Li, Shuoshuo, Lu, Yiming, Li, Xiaoheng, Liao, Yajin, Peng, Zhixin, Li, Yunfeng, Hou, Lin, Yuan, Zengqiang, Cheng, Jinbo

“…Abstract Background Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- and stress-related disorders such as…”
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Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior by Li, Xiaoheng, Peng, Zhixin, Jiang, Lingling, Zhang, Ping, Yang, Pin, Yuan, Zengqiang, Cheng, Jinbo

“…Major depression is one of the most common psychiatric disorders worldwide, inflicting suffering, significant reduction in life span, and financial burdens on…”
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Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling by Li, Xiaoheng, Fang, Yinghui, Chen, Lanlan, Quan, Hehua, Wang, Yiyan, Ge, Ren-Shan

“…Bone morphogenetic protein 4 (BMP4) is an important member of the transforming growth factor-β superfamily. BMP4 is expressed in the Leydig cell lineage. We…”
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Bisphenols and Leydig Cell Development and Function by Li, Xiaoheng, Wen, Zina, Wang, Yiyan, Mo, Jiaying, Zhong, Ying, Ge, Ren-Shan

“…Bisphenol A (BPA) is a ubiquitous environmental pollutant, mainly from the production and use of plastics and the degradation of wastes related to industrial…”
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Glucagon-like peptide-1 promotes Leydig cell regeneration from stem cells in rats by Li, Xiaoheng, Chen, Lanlan, Wang, Yiyan, Li, Huitao, Zhu, Qiqi, Ge, Ren-Shan

“…In brief Glucagon-like peptide-1 stimulates stem Leydig cell development. Glucagon-like peptide-1 stimulates stem Leydig cell differentiation without affecting…”
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The role and regulatory mechanism of m6A methylation in the nervous system by Jiang, Lingling, Li, Xiaoheng, Wang, Shasha, Yuan, Zengqiang, Cheng, Jinbo

“…N6-methyladenosine (m 6 A) modification regulates RNA translation, splicing, transport, localization, and stability at the post-transcriptional level. The m 6…”
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Bisphenol H exposure disrupts Leydig cell function in adult rats via oxidative stress-mediated m6A modifications: Implications for reproductive toxicity by Wang, Shaowei, Lu, Han, Su, Ming, He, Jiayi, Tang, Yunbing, Ying, Yingfen, Chen, Zhuoqi, Zhu, Qiqi, Ge, Ren-Shan, Li, Huitao, Li, Xiaoheng

“…Bisphenol H (BPH) has emerged as a potential alternative to bisphenol A (BPA), which has been curtailed for use due to concerns over its reproductive and…”
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A green deprotection strategy: Removing acid-labile protecting groups using lemon juice/ethanol as the solvent by Wang, Weiding, Chen, Yinzhe, Li, Xiaoheng, Zhang, Qian

“…Lemon juice has been studied and reported as an efficient catalyst or green medium in organic synthesis. The present digest paper shows the successful and…”
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Prenatal diethylhexylphthalate exposure disturbs adult Leydig cell function via epigenetic downregulation of METTL4 expression in male rats by Zhu, Qiqi, Zhu, Shanshan, Li, Qiyao, Hu, Chunnan, Pan, Chengshuang, Li, Huitao, Zhu, Yang, Li, Xiaoheng, Tang, Yunbing, Ge, Ren-shan

“…Prenatal exposure to diethylhexyl phthalate (DEHP) has been linked with a decline in testosterone levels in adult male rats, but the underlying mechanism…”
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The impact of tetrachlorobisphenol A exposure during puberty: Altered Leydig cell development and induced endoplasmic reticulum stress in male mice by Yao, Zhiang, Tao, Shanhui, Lai, Yingji, Yu, Yang, Wang, Hong, Sang, Jianmin, Yang, Jin, Li, Huitao, Li, Xiaoheng, Li, Yang, Ning, Yangyang, Ge, Ren-Shan, Li, Shijun

“…Tetrachlorobisphenol A (TCBPA), a halogenated flame retardant and endocrine disruptor, has been detected in human urine and serum. While previous research has…”
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Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies by Wang, Yiyan, Ni, Chaobo, Li, Xiaoheng, Lin, Zhenkun, Zhu, Qiqi, Li, Linxi, Ge, Ren-Shan

“…Male fetal Leydig cells in the testis secrete androgen and insulin-like 3, determining the sexual differentiation. The abnormal development of fetal Leydig…”
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PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules by Li, Linxi, Gao, Sheng, Wang, Lingling, Bu, Tiao, Chu, Jinjin, Lv, Lixiu, Tahir, Anam, Mao, Baiping, Li, Huitao, Li, Xiaoheng, Wang, Yiyan, Wu, Xiaolong, Ge, Renshan, Cheng, C Yan

“…Inversin is an integrated component of the Frizzled (Fzd)/Dishevelled (Dvl)/Diversin planar cell polarity (PCP) complex that is known to work in concert with…”
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Knowledge, Attitude, and Practice towards Influenza Vaccination among Older Adults in Southern China during the COVID-19 Pandemic by You, Yating, Li, Xiaoheng, Chen, Binglin, Zou, Xuan, Liu, Gang, Han, Xinxin

“…Influenza is prevalent globally, leading to severe morbidity and mortality. During the pandemic, knowledge, attitude, and practice (KAP) towards influenza…”
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