Search Results - "Li, Xaria X"

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity by Li, Xaria X, Lee, John D, Kemper, Claudia, Woodruff, Trent M

“…Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors,…”
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C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages by Li, Xaria X, Clark, Richard J, Woodruff, Trent M

“…The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly recognized as an immune modulator. C5a acts through two C5a…”
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Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation by Li, Xaria X., Woodruff, Trent M.

“…The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we present a protocol to screen the effects of different agonists and…”
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The "C3aR Antagonist" SB290157 is a Partial C5aR2 Agonist by Li, Xaria X, Kumar, Vinod, Clark, Richard J, Lee, John D, Woodruff, Trent M

“…Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR,…”
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TLQP-21 is a low potency partial C3aR activator on human primary macrophages by Li, Xaria X, Lee, John D, Lee, Han S, Clark, Richard J, Woodruff, Trent M

“…TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and…”
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Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2 by Brennan, Faith H, Jogia, Trisha, Gillespie, Ellen R, Blomster, Linda V, Li, Xaria X, Nowlan, Bianca, Williams, Gail M, Jacobson, Esther, Osborne, Geoff W, Meunier, Frederic A, Taylor, Stephen M, Campbell, Kate E, MacDonald, Kelli Pa, Levesque, Jean-Pierre, Woodruff, Trent M, Ruitenberg, Marc J

“…Traumatic spinal cord injury (SCI) triggers an acute-phase response that leads to systemic inflammation and rapid mobilization of bone marrow (BM) neutrophils…”
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Emerging Insights into the Structure and Function of Complement C5a Receptors by Pandey, Shubhi, Maharana, Jagannath, Li, Xaria X., Woodruff, Trent M., Shukla, Arun K.

“…Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via…”
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Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors by Pandey, Shubhi, Kumari, Punita, Baidya, Mithu, Kise, Ryoji, Cao, Yubo, Dwivedi-Agnihotri, Hemlata, Banerjee, Ramanuj, Li, Xaria X., Cui, Cedric S., Lee, John D., Kawakami, Kouki, Maharana, Jagannath, Ranjan, Ashutosh, Chaturvedi, Madhu, Jhingan, Gagan Deep, Laporte, Stéphane A., Woodruff, Trent M., Inoue, Asuka, Shukla, Arun K.

“…G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors (7TMRs), typically interact with two distinct signal-transducers, i.e., G…”
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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein by Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J., Khromykh, Alexander A., Chappell, Keith J., Watterson, Daniel, Woodruff, Trent M.

“…Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also…”
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Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function by Li, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A.B., Clark, Richard J., Woodruff, Trent M.

“…[Display omitted] The complement fragment C5a is a core effector of complement activation. C5a, acting through its major receptor C5aR1, exerts powerful…”
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Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing by Li, Xaria X, Fung, Jenny N, Clark, Richard J, Lee, John D, Woodruff, Trent M

“…The complement factor C5a is a core effector product of complement activation. C5a, acting through its receptors C5aR1 and C5aR2, exerts pleiotropic…”
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Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists by Li, Xaria X., Clark, Richard J., Woodruff, Trent M.

“…•Peptides EP54, EP67 and C5apep are widely used in complement C5a research.•EP54, EP67 and C5apep have off-target activities at C5aR2 and C3aR.•EP54 and EP67…”
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New concepts on the therapeutic control of complement anaphylatoxin receptors by Hawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J., Woodruff, Trent M.

“…•Complement underlies the pathogenesis of a vast number of inflammatory disorders.•Driving the complement inflammatory response are the anaphylatoxins, C5a and…”
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Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors by Yadav, Manish K., Maharana, Jagannath, Yadav, Ravi, Saha, Shirsha, Sarma, Parishmita, Soni, Chahat, Singh, Vinay, Saha, Sayantan, Ganguly, Manisankar, Li, Xaria X., Mohapatra, Samanwita, Mishra, Sudha, Khant, Htet A., Chami, Mohamed, Woodruff, Trent M., Banerjee, Ramanuj, Shukla, Arun K., Gati, Cornelius

“…The complement system is a critical part of our innate immune response, and the terminal products of this cascade, anaphylatoxins C3a and C5a, exert their…”
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Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1 by Pandey, Shubhi, Li, Xaria X., Srivastava, Ashish, Baidya, Mithu, Kumari, Punita, Dwivedi, Hemlata, Chaturvedi, Madhu, Ghosh, Eshan, Woodruff, Trent M., Shukla, Arun K.

“…The human complement component, C5a, binds two different seven-transmembrane receptors termed C5aR1 and C5aR2. C5aR1 is a prototypical G-protein–coupled…”
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Unexpected Off-Target Activities for Recombinant C5a in Human Macrophages by Li, Xaria X, Gorman, Declan M, Lee, John D, Clark, Richard J, Woodruff, Trent M

“…The anaphylatoxin C5a is core effector of complement activation. C5a exerts potent proinflammatory and immunomodulatory actions through interacting with its…”
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Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity by Gorman, Declan M, Li, Xaria X, Lee, John D, Fung, Jenny N, Cui, Cedric S, Lee, Han Siean, Rolfe, Barbara E, Woodruff, Trent M, Clark, Richard J

“…The anaphylatoxin C5a is a complement peptide associated with immune-related disorders. C5a binds with equal potency to two GPCRs, C5aR1 and C5aR2. Multiple…”
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C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma by Nabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., Akhir, Fazrena N. M., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M., Rolfe, Barbara E.

“…ABSTRACT The canonical complement component 5a (C5a) receptor (C5aR) 1 has well‐described roles in tumorigenesis but the contribution of the second receptor,…”
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Development of Synthetic Human and Mouse C5a: Application to Binding and Functional Assays In Vitro and In Vivo by Gorman, Declan M, Li, Xaria X, Payne, Colton D, Cui, Cedric S, Lee, John D, Rosengren, K. Johan, Woodruff, Trent M, Clark, Richard J

“…The complement activation peptide C5a is a key mediator of inflammation that is associated with numerous immune disorders. C5a binds and activates two…”
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors by Alexander, Stephen PH, Davenport, Anthony P, Peters, John A, Veale, Emma L, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M., Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner‐Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P., Ceruti, Stefania, Chazot, Paul, Chini, Bice, Cianciulli, Antonia, Couture, Réjean, Dent, Gordon, Douglas, Steven D., Eguchi, Satoru, Escher, Emanuel, Fong, Tung, Gasparo, Marc de, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L., Gregory, Karen J., Gundlach, Andrew L., Hamann, Jörg, Hanson, Julien, Hauger, Richard L., Hay, Debbie L., Heinemann, Akos, Hollenberg, Morley D., Holliday, Nicholas D., Horiuchi, Mastgugu, Husain, Ahsan, Jacobson, Kenneth A., Jensen, Robert T., Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kennedy, Charles, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans‐Jürgen, Leeman, Susan E., Leprince, Jérôme, Li, Xaria X., Williams, Tom Lloyd, Macrae, Robyn, Maguire, Janet, McArdle, Craig A., Melmed, Shlomo, Mitolo, Vincenzo, Müller, Christa E., Murphy, Philip, Nahon, Jean‐Louis, Norel, Xavier, Nyimanu, Duuamene, Pertwee, Roger G., Pin, Jean‐Philippe, Prossnitz, Eric R., Quinn, Mark, Ramachandran, Rithwik, Rondard, Philippe, Ruzza, Chiara, Sanger, Gareth J., Schöneberg, Torsten, Schulz, Stefan, Segaloff, Deborah L., Serhan, Charles N., Stoddart, Leigh A., Summers, Roger, Tan, Valerie P., Thal, David, Thomas, Walter (Wally), Timmermans, Pieter B. M. W. M., Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Walker, Christopher S., Ward, Donald T., Ye, Richard D.

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
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