Search Results - "Li, Wenbao"
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Hydrogen isotope records of long-chain alkanes from the monsoon boundary zone over the last 2400 years in North China
Published in Journal of hydrology (Amsterdam) (01-04-2024)“…•The δDwax-C31 value can be used as a proxy for the regional precipitation in the monsoon boundary zone (MBZ).•Over the past 2400 years, precipitation in the…”
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Seasonal dynamics shaping bacterial community structure and networks in a Multi Geomorphological Unit System (MGUS) within the eastern Ulansuhai Lake Basin, North China
Published in Catena (Giessen) (01-12-2024)“…•MGUS displayed an overarching pattern of “macro-stability and micro-variability”•Water improved the connectivity among geomorphic units.•Soil properties, not…”
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Characterization of bacterial community dynamics dominated by salinity in lakes of the Inner Mongolian Plateau, China
Published in Frontiers in microbiology (21-08-2024)“…Microorganisms in lakes are sensitive to salinity fluctuations. Despite extensive prior research on bacterial communities, our understanding of their…”
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Middle to Late Quaternary changes in ice rafting and deep current transport on the Alpha Ridge, central Arctic Ocean and their responses to climatic cyclicities
Published in Global and planetary change (01-01-2023)“…To address the Arctic Ocean response to the Quaternary climate change, three sediment cores from the Alpha Ridge, central Arctic Ocean, were analyzed for…”
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Composition, interaction networks, and nitrogen metabolism patterns of bacterioplankton communities in a grassland type Lake: a case of Hulun Lake, China
Published in Frontiers in microbiology (2023)“…The composition of bacterial communities in freshwater ecosystems is influenced by numerous factors including environmental conditions and biological…”
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Lake-level variation of Dali Lake in mid-east of inner Mongolia since the Late Holocene
Published in Quaternary international (10-05-2021)“…In recent years, the area of Dali Lake has shrunk significantly, resulting in extremely serious ecological and environmental problems. Combining records from…”
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Analyzing the Vertical Recharge Mechanism of Groundwater Using Ion Characteristics and Water Quality Indexes in Lake Hulun
Published in Water (Basel) (01-06-2024)“…The water level of Lake Hulun has changed dramatically in recent years. The interannual interaction between groundwater and lake water is an important factor…”
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Characteristics of palaeosalinity and palaeoredox records in sediment from Dali Lake: Climate change in North China from 0 to 2100 cal BP
Published in Quaternary geochronology (01-10-2020)“…To understand the salinity, redox characteristics, and climatology of Dali Lake during the late Holocene, we analysed trace element records from a…”
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Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy
Published in Marine drugs (29-11-2022)“…Phenylahistin is a naturally occurring marine product with a diketopiperazine structure that can bind to the colchicine site of microtubulin as a possible…”
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Combination of a novel microtubule inhibitor MBRI-001 and gemcitabine synergistically induces cell apoptosis by increasing DNA damage in pancreatic cancer cell lines
Published in Investigational new drugs (01-10-2020)“…Summary Pancreatic cancer (PC) is a highly malignant cancer with poor prognosis. Although gemcitabine (GEM; 2′,2′-difluoro-deoxycytidine) has been used as the…”
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Characterizing Free-Living and Particle-Attached Bacterial Communities of a Shallow Lake on the Inner Mongolia-Xinjiang Plateau, China
Published in Water (Basel) (01-03-2023)“…Bacteria play a critical role in the material and energy-cycling processes of lake ecosystems. To understand the characteristics of the bacterial community in…”
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Status and analysis of undetected plague cases in Yunnan Province, China
Published in Frontiers in public health (04-09-2024)“…The virulence of strains in the plague focus is relatively low. The purpose of this study was to investigate the undetected, sporadic plague cases in plague…”
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SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine
Published in Toxicology and applied pharmacology (01-08-2012)“…SL-01, an oral gemcitabine derivative, was synthesized by introducing the moiety of 3-(dodecyloxycarbonyl)pyrazine-2-carbonyl at the N4-position on the…”
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Pharmacokinetics and metabolism of SL-01, a prodrug of gemcitabine, in rats
Published in Cancer chemotherapy and pharmacology (01-06-2013)“…Purpose SL-01, dodecyl-3-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl) carbamoyl)…”
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Synthesis and Pharmacokinetic Property Improvement of Deuterated Plinabulin 9
Published in Journal of Ocean University of China (01-04-2017)“…Plinabulin, a potent microtubule-targeting agent, is derived from marine natural diketopiperazine ‘phenylahistin’. To develop novel plinabulin analogue that…”
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SL1122-37, a novel derivative of sorafenib, has greater effects than sorafenib on the inhibition of human hepatocellular carcinoma (HCC) growth and prevention of angiogenesis
Published in BioScience Trends (01-01-2013)“…SL1122-37 is a novel derivative of sorafenib that was characterized by introducing trifluoromethyl on the 4-position of indazole. We aimed to evaluate the…”
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Effects of Polymer Supports on the Kinetics of Solid-Phase Organic Reactions: A Comparison of Polystyrene- and TentaGel-Based Resins
Published in Journal of organic chemistry (12-06-1998)“…A quantitative comparison of kinetics of seven solid-phase organic reactions on two commonly used resin supports, polystyrene (PS)- and Tentagel (TG)-based…”
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Exploring environment-specific regulation: Characterizing bacterioplankton community dynamics in a typical lake of Inner Mongolia, China
Published in Environmental research (15-07-2024)“…Lakes serve as heterogeneous ecosystems with rich microbiota. Although previous studies on bacterioplankton have advanced our understanding, there are gaps in…”
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Study on the Preparation and Antileukemic Activity of New Lipophilic 1-β-D-arabinofuranosylcytosine Derivatives
Published in Journal of Ocean University of China (01-04-2018)“…Cytarabine (1-β-D-arabinofuranosylcytosine, Ara-C), isolated from a Caribbean sponge species Tethyacrypta , is the first antitumor drug from a marine resource…”
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Novel derivatives of capsaicin as a potent hypolipidemic and anti-obesity agent
Published in Molecular diversity (24-10-2024)“…Capsaicin is a natural product with multiple biological activities, such as anti-inflammatory, analgesic, weight loss, anti-cancer and cardiovascular disease…”
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