Search Results - "Li, Wanren"

Iron chelator research: past, present, and future by Tam, Tim F, Leung-Toung, Regis, Li, Wanren, Wang, Yingsheng, Karimian, Khashayar, Spino, Michael

“…The occurrence of in vivo iron toxicity in the human body can be categorized into iron overload and non-iron overload conditions. Iron overload conditions are…”
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Thiol-dependent enzymes and their inhibitors: a review by Leung-Toung, Regis, Li, Wanren, Tam, Tim F, Karimian, Khashayar

“…Biological thiol-dependent enzymes have recently received extensive attention in the literature because of their involvement in a variety of physiopathological…”
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Thiol proteases: inhibitors and potential therapeutic targets by Leung-Toung, Regis, Zhao, Yanqing, Li, Wanren, Tam, Tim F, Karimian, Khashayar, Spino, Michael

“…A better understanding of the biological roles and the pathological consequences of thiol-dependent enzymes has emerged in recent years, and hence considerable…”
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Synthesis of 3-Substituted Bicyclic Imidazo[1,2-d][1,2,4]thiadiazoles and Tricyclic Benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazoles by Leung-Toung, Regis, Tam, Tim F, Zhao, Yanqing, Simpson, Craig D, Li, Wanren, Desilets, Denis, Karimian, Khashayar

“…A versatile synthetic route to potentially useful fused-ring [1,2,4]thiadiazole scaffolds (e.g., 7a and 10b) via exchange reactions of the precursor…”
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Medicinal chemistry and properties of 1,2,4-thiadiazoles by Tam, Tim Fat, Leung-Toung, Regis, Li, Wanren, Spino, Michael, Karimian, Khashayar

“…1,2,4-Thiadiazole is a distinctive class of small heterocyclic thiol trapping agents that serve as an interesting pharmacophore in the design of inhibitors…”
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1,2,4-Thiadiazole: A novel Cathepsin B inhibitor by Leung-Toung, Regis, Wodzinska, Jolanta, Li, Wanren, Lowrie, Jayme, Kukreja, Rahul, Desilets, Denis, Karimian, Khashayar, Tam, Tim Fat

“…A novel class of Cathepsin B inhibitors has been developed with a 1,2,4-thiadiazole heterocycle as the thiol trapping pharmacophore. Several compounds with…”
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