Search Results - "Li, Vivian"

A brief history of organoids by Corrò, Claudia, Novellasdemunt, Laura, Li, Vivian S W

“…In vitro cell cultures are crucial research tools for modeling human development and diseases. Although the conventional monolayer cell cultures have been…”
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Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture by Giobbe, Giovanni Giuseppe, Crowley, Claire, Luni, Camilla, Campinoti, Sara, Khedr, Moustafa, Kretzschmar, Kai, De Santis, Martina Maria, Zambaiti, Elisa, Michielin, Federica, Meran, Laween, Hu, Qianjiang, van Son, Gijs, Urbani, Luca, Manfredi, Anna, Giomo, Monica, Eaton, Simon, Cacchiarelli, Davide, Li, Vivian S. W., Clevers, Hans, Bonfanti, Paola, Elvassore, Nicola, De Coppi, Paolo

“…Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is…”
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Cell-type-specific signaling networks in heterocellular organoids by Qin, Xiao, Sufi, Jahangir, Vlckova, Petra, Kyriakidou, Pelagia, Acton, Sophie E., Li, Vivian S. W., Nitz, Mark, Tape, Christopher J.

“…Despite the widespread adoption of organoids as biomimetic tissue models, methods to comprehensively analyze cell-type-specific post-translational modification…”
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Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand by Boj, Sylvia F., van Es, Johan H., Huch, Meritxell, Li, Vivian S.W., José, Anabel, Hatzis, Pantelis, Mokry, Michal, Haegebarth, Andrea, van den Born, Maaike, Chambon, Pierre, Voshol, Peter, Dor, Yuval, Cuppen, Edwin, Fillat, Cristina, Clevers, Hans

“…Most studies on TCF7L2 SNP variants in the pathogenesis of type 2 diabetes (T2D) focus on a role of the encoded transcription factor TCF4 in β cells. Here, a…”
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Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms by Novellasdemunt, Laura, Antas, Pedro, Li, Vivian S W

“…The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic development and tissue homeostasis. Notably, comprehensive genetic…”
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Hallmarks of intestinal stem cells by Baulies, Anna, Angelis, Nikolaos, Li, Vivian S W

“…Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory…”
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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy by Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

“…Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in…”
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Modelling intestinal inflammation and infection using ‘mini-gut’ organoids by Li, Vivian S. W.

“…In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings…”
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Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds by Meran, Laween, Tullie, Lucinda, Eaton, Simon, De Coppi, Paolo, Li, Vivian S. W.

“…Tissue engineering is an interdisciplinary field that combines stem cells and matrices to form functional constructs that can be used to repair damaged tissues…”
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Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components by Meran, Laween, Li, Vivian S. W., Baulies, Anna

“…The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of…”
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Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon by Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans

“…Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5⁺) stem cells reside at crypt bottoms of the small and large intestine. Small…”
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Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer by Wang, Kai, Yuen, Siu Tsan, Xu, Jiangchun, Lee, Siu Po, Yan, Helen H N, Shi, Stephanie T, Siu, Hoi Cheong, Deng, Shibing, Chu, Kent Man, Law, Simon, Chan, Kok Hoe, Chan, Annie S Y, Tsui, Wai Yin, Ho, Siu Lun, Chan, Anthony K W, Man, Jonathan L K, Foglizzo, Valentina, Ng, Man Kin, Chan, April S, Ching, Yick Pang, Cheng, Grace H W, Xie, Tao, Fernandez, Julio, Li, Vivian S W, Clevers, Hans, Rejto, Paul A, Mao, Mao, Leung, Suet Yi

“…Suet Yi Leung, Mao Mao and colleagues report whole-genome sequencing of 100 gastric cancers and DNA copy number, gene expression and methylation profiling of…”
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Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex by Li, Vivian S.W., Ng, Ser Sue, Boersema, Paul J., Low, Teck Y., Karthaus, Wouter R., Gerlach, Jan P., Mohammed, Shabaz, Heck, Albert J.R., Maurice, Madelon M., Mahmoudi, Tokameh, Clevers, Hans

“…Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key regulated step of the Wnt pathway. It is incompletely understood how…”
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A mini-colon models colon cancer and its microenvironment by Hutton, Colin, Li, Vivian S W

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Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure by Meran, Laween, Massie, Isobel, Campinoti, Sara, Weston, Anne E., Gaifulina, Riana, Tullie, Lucinda, Faull, Peter, Orford, Michael, Kucharska, Anna, Baulies, Anna, Novellasdemunt, Laura, Angelis, Nikolaos, Hirst, Elizabeth, König, Julia, Tedeschi, Alfonso Maria, Pellegata, Alessandro Filippo, Eli, Susanna, Snijders, Ambrosius P., Collinson, Lucy, Thapar, Nikhil, Thomas, Geraint M. H., Eaton, Simon, Bonfanti, Paola, De Coppi, Paolo, Li, Vivian S. W.

“…Intestinal failure, following extensive anatomical or functional loss of small intestine, has debilitating long-term consequences for children 1 . The priority…”
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Yap in regeneration and symmetry breaking by Li, Vivian S. W.

“…Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of…”
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration by Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., Li, Vivian S. W., van de Wetering, Marc, Sato, Toshiro, Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Vries, Robert G., Grompe, Markus, Clevers, Hans

“…A mouse model of liver damage has identified a population of Lrg5 + liver stem cells that can generate hepatoctyes and bile ducts in vivo. Wake-up call for…”
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Building gut from scratch — progress and update of intestinal tissue engineering by Tullie, Lucinda, Jones, Brendan C., De Coppi, Paolo, Li, Vivian S. W.

“…Short bowel syndrome (SBS), a condition defined by insufficient absorptive intestinal epithelium, is a rare disease, with an estimated prevalence up to 0.4 in…”
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Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors by Kosinski, Cynthia, Li, Vivian S.W, Chan, Annie S.Y, Zhang, Ji, Ho, Coral, Tsui, Wai Yin, Chan, Tsun Leung, Mifflin, Randy C, Powell, Don W, Yuen, Siu Tsan, Leung, Suet Yi, Chen, Xin

“…Human colonic epithelial cell renewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways. To identify genetic…”
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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling by de Lau, Wim, Barker, Nick, Low, Teck Y., Koo, Bon-Kyoung, Li, Vivian S. W., Teunissen, Hans, Kujala, Pekka, Haegebarth, Andrea, Peters, Peter J., van de Wetering, Marc, Stange, D. E., van Es, J., Guardavaccaro, Daniele, Schasfoort, Richard B. M., Mohri, Yasuaki, Nishimori, Katsuhiko, Mohammed, Shabaz, Heck, Albert J. R., Clevers, Hans

“…The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments. We find that conditional deletion of…”
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