Search Results - "Li, Stephen K.H."

Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored by Li, Stephen K.H, Martin, Alberto

“…Colorectal cancer (CRC) remains one of the most prevalent cancers worldwide. In sporadic CRC, mutations frequently occur in the DNA mismatch repair (MMR)…”
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An automated approach to high-plex cytometric immunophenotyping with CyTOF XT by Li, Stephen K.H., Zabinyakov, Nick, Bouzekri, Alexandre, Straus, Rita, Jong, Raymond, Sullivan, Michael, Loboda, Alexander, Majonis, Daniel, Loh, Christina

“…Abstract CyTOF® mass cytometry is a single-cell analysis platform that uses isotope-tagged antibodies to resolve 50-plus markers in a single tube without…”
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Expanding the capabilities of the Maxpar Direct Immune Profiling Assay with additional markers, and customization of the analysis model in Maxpar Pathsetter by Li, Stephen K.H., Mujib, Shariq, Cohen, Michael, Yao, Huihui, Majonis, Daniel, Loh, Christina

“…Abstract Mass cytometry, which utilizes CyTOF® technology, is a single-cell analysis platform that uses metal-tagged antibodies. CyTOF can resolve more than 50…”
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A robust human immunophenotyping workflow using CyTOF technology coupled with Maxpar Pathsetter, an automated data analysis software by Li, Stephen K.H., Majonis, Daniel, Bagwell, C. Bruce, Hunsberger, Benjamin C., Baranov, Vladimir, Ornatsky, Olga

“…Abstract Mass cytometry, which utilizes CyTOF® technology, is a single-cell analysis platform that uses metal-tagged antibodies. An advantage of CyTOF is its…”
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Customizing Maxpar Direct Immune Profiling Assay with Additional Surface Marker and Intracellular Cytokine Staining Workflows for Expanded Mass Cytometry Panels by Petes, Carlene, Li, Stephen K H, Mujib, Shariq, Poulin, Michelle M, Saederup, Noah, Quong, Andrew A, Loh, Christina

“…Mass cytometry, or cytometry by time-of-flight (the basis for Fluidigm CyTOF technology), is a system for single-cell detection using antibodies tagged with…”
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An efficient human whole blood workflow using CyTOF technology: a lyophilized 30-plex antibody panel coupled with automated data analysis by Li, Stephen K.H., Majonis, Daniel, Bagwell, C. Bruce, Hunsberger, Benjamin C., Baranov, Vladimir, Ornatsky, Olga

“…Abstract CyTOF® mass cytometry is a highly multiplexed, single-cell analysis platform that uses metal-tagged antibodies. A significant advantage of this…”
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PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development by Batista, Carolina R, Li, Stephen K H, Xu, Li S, Solomon, Lauren A, DeKoter, Rodney P

“…B cell development and Ig rearrangement are governed by cell type- and developmental stage-specific transcription factors. PU.1 and Spi-B are…”
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Abstract 2098: Genome-wide comparison of PU.1 and Spi-B binding sites in a mouse B lymphoma cell line by Solomon, Lauren A., Li, Stephen K.h., Piskorz, Jan, Xu, Li S., DeKoter, Rodney P.

“…Abstract Background. The E26-transformation-specific (ETS) transcription factor Spi-B is required for the survival of Activated B Cell-type Diffuse Large B…”
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Abstract 3908: A streamlined and automated approach to high-content cytometric immunophenotyping with CyTOF XT by Selvanantham, Thiru, Li, Stephen K.H., Zabinyakov, Nick, Bouzekri, Alexandre, Jong, Raymond, Sullivan, Michael, Laboda, Alexander, Majonis, Daniel, Loh, Christina

“…Abstract High-parameter immune profiling is crucial in translational and clinical research to quantify changes in immune cell populations over time. CyTOF®…”
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Genome-wide comparison of PU.1 and Spi-B binding sites in a mouse B lymphoma cell line by Solomon, Lauren A, Li, Stephen K H, Piskorz, Jan, Xu, Li S, DeKoter, Rodney P

“…Spi-B and PU.1 are highly related members of the E26-transformation-specific (ETS) family of transcription factors that have similar, but not identical, roles…”
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PU.1 opposes IL-7-dependent proliferation of developing B cells with involvement of the direct target gene bruton tyrosine kinase by Christie, Darah A, Xu, Li S, Turkistany, Shereen A, Solomon, Lauren A, Li, Stephen K H, Yim, Edmund, Welch, Ian, Bell, Gillian I, Hess, David A, DeKoter, Rodney P

“…Deletion of genes encoding the E26 transformation-specific transcription factors PU.1 and Spi-B in B cells (CD19-CreΔPB mice) leads to impaired B cell…”
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Nfkb1 Activation by the E26 Transformation-Specific Transcription Factors PU.1 and Spi-B Promotes Toll-Like Receptor-Mediated Splenic B Cell Proliferation by Li, Stephen K. H., Abbas, Ali K., Solomon, Lauren A., Groux, Gaëlle M. N., DeKoter, Rodney P.

“…Generation of antibodies against T-independent and T-dependent antigens requires Toll-like receptor (TLR) engagement on B cells for efficient responses…”
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Identification of a negative regulatory role for spi-C in the murine B cell lineage by Li, Stephen K H, Solomon, Lauren A, Fulkerson, Patricia C, DeKoter, Rodney P

“…Spi-C is an E26 transformation-specific family transcription factor that is highly related to PU.1 and Spi-B. Spi-C is expressed in developing B cells, but its…”
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Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia by Sokalski, Kristen M., Li, Stephen K.H., Welch, Ian, Cadieux-Pitre, Heather-Anne T., Gruca, Marek R., DeKoter, Rodney P.

“…The E26 transformation-specific (Ets) transcription factor PU.1 is required to generate lymphoid progenitor cells from hematopoietic stem cells, but it is not…”
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PU.1 and Spi-B Oppose Transformation Of Pre-B Cells Through Activation Of Key Genes Involved In B Cell Receptor Signalling by Christie, Darah A., Turkistany, Shereen A., Xu, Li S., Li, Stephen K.H., Welch, Ian, Broughton, Heather C., Bell, Gillian I., Hess, David A., DeKoter, Rodney P.

“…B cell development is controlled by stage-specific expression of transcription factors. Aberrant expression of such factors can lead to B cell acute…”
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