Search Results - "Li, Shengying"

Expansion of chemical space for natural products by uncommon P450 reactions by Zhang, Xingwang, Li, Shengying

“…Covering: 2000 to 2017Cytochrome P450 enzymes (P450s) are the most versatile biocatalysts in nature. The catalytic competence of these extraordinary…”
Get more information

Redox Partners: Function Modulators of Bacterial P450 Enzymes by Li, Shengying, Du, Lei, Bernhardt, Rita

“…The superfamily of cytochrome P450 monooxygenases (P450s) is widespread in all kingdoms of life. Functionally versatile P450s are extensively involved in…”
Get full text

A novel and robust recombinant Pichia pastoris yeast whole cell biocatalyst with intracellular overexpression of a Thermomyces lanuginosus lipase: Preparation, characterization and application in biodiesel production by Yan, Jinyong, Zheng, Xianliang, Li, Shengying

“…•A novel and robust Pichia pastoris yeast whole cell biocatalyst is reported.•The short chain alcohol tolerant and easily scalable biocatalyst is…”
Get full text

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy by Zhao, Wei, Cong, Ying, Li, Hong-Mei, Li, Shengying, Shen, Yuemao, Qi, Qingsheng, Zhang, Youming, Li, Yue-Zhong, Tang, Ya-Jie

“…Covering: up to 2020As a main bioactive component of the Chinese, Indian, and American Podophyllum species, the herbal medicine, podophyllotoxin (PTOX)…”
Get more information

Functional expression and regulation of eukaryotic cytochrome P450 enzymes in surrogate microbial cell factories by Durairaj, Pradeepraj, Li, Shengying

“…Cytochrome P450 (CYP) enzymes play crucial roles during the evolution and diversification of ancestral monocellular eukaryotes into multicellular eukaryotic…”
Get full text

Compartmentalized biosynthesis of mycophenolic acid by Zhang, Wei, Du, Lei, Qu, Zepeng, Zhang, Xingwang, Li, Fengwei, Li, Zhong, Qi, Feifei, Wang, Xiao, Jiang, Yuanyuan, Men, Ping, Sun, Jingran, Cao, Shaona, Geng, Ce, Qi, Fengxia, Wan, Xiaobo, Liu, Changning, Li, Shengying

“…Mycophenolic acid (MPA) from filamentous fungi is the first natural product antibiotic to be isolated and crystallized, and a first-line immunosuppressive drug…”
Get full text

Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids by Pan, Yunjun, Li, Guobang, Liu, Ruxin, Guo, Jiawei, Liu, Yunjie, Liu, Mingyu, Zhang, Xingwang, Chi, Luping, Xu, Kangwei, Wu, Ruibo, Zhang, Yuzhong, Li, Yuezhong, Gao, Xiang, Li, Shengying

“…Cytochrome P450 enzymes play important roles in the biosynthesis of macrolide antibiotics by mediating a vast variety of regio- and stereoselective oxidative…”
Get full text

RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla by Gao, Xiaoyang, Su, Qixuan, Li, Jing, Yang, Wenjing, Yao, Baolin, Guo, Jiawei, Li, Shengying, Liu, Changning

“…Abstract Background Plants synthesize metabolites to adapt to a continuously changing environment. Metabolite biosynthesis often occurs in response to the…”
Get full text

Implementation and Performance Analysis of Constellation Dynamic Selection in Multi-Constellation RAIM by Meng, Qian, Zhuang, Yuan, Li, Shengying

“…Global navigation satellite system (GNSS) plays a crucial role in many fields, such as aerospace and transportation. Integrity is the measure of trust used in…”
Get full text

Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase by Li, Zhong, Zhang, Lilan, Xu, Kangwei, Jiang, Yuanyuan, Du, Jieke, Zhang, Xingwang, Meng, Ling-Hong, Wu, Qile, Du, Lei, Li, Xiaoju, Hu, Yuechan, Xie, Zhenzhen, Jiang, Xukai, Tang, Ya-Jie, Wu, Ruibo, Guo, Rey-Ting, Li, Shengying

“…Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also…”
Get full text

A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA by Li, Chun-Yang, Wang, Xiu-Juan, Chen, Xiu-Lan, Sheng, Qi, Zhang, Shan, Wang, Peng, Quareshy, Mussa, Rihtman, Branko, Shao, Xuan, Gao, Chao, Li, Fuchuan, Li, Shengying, Zhang, Weipeng, Zhang, Xiao-Hua, Yang, Gui-Peng, Todd, Jonathan D, Chen, Yin, Zhang, Yu-Zhong

“…Dimethylsulfoniopropionate (DMSP) is an abundant and ubiquitous organosulfur molecule in marine environments with important roles in global sulfur and nutrient…”
Get full text

A new method of evaluating energy efficiency of public buildings in China by Guo, Chunmei, Bian, Chenhang, Liu, Qinghua, You, Yuwen, Li, Shengying, Wang, Leilei

“…Traditional building energy evaluation methods usually adopt a single energy use indicator as the benchmark. However, such single-indicator based methods often…”
Get full text

Deciphering the late steps of rifamycin biosynthesis by Qi, Feifei, Lei, Chao, Li, Fengwei, Zhang, Xingwang, Wang, Jin, Zhang, Wei, Fan, Zhen, Li, Weichao, Tang, Gong-Li, Xiao, Youli, Zhao, Guoping, Li, Shengying

“…Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of…”
Get full text

Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis by Wang, Yan, Wang, Peng, Cao, Hai-Yan, Ding, Hai-Tao, Su, Hai-Nan, Liu, Shi-Cheng, Liu, Guangfeng, Zhang, Xia, Li, Chun-Yang, Peng, Ming, Li, Fuchuan, Li, Shengying, Chen, Yin, Chen, Xiu-Lan, Zhang, Yu-Zhong

“…The collagenases of Vibrio species, many of which are pathogens, have been regarded as an important virulence factor. However, there is little information on…”
Get full text

New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners by Zhang, Wei, Liu, Yi, Yan, Jinyong, Cao, Shaona, Bai, Fali, Yang, Ying, Huang, Shaohua, Yao, Lishan, Anzai, Yojiro, Kato, Fumio, Podust, Larissa M, Sherman, David H, Li, Shengying

“…Cytochrome P450 enzymes are capable of catalyzing a great variety of synthetically useful reactions such as selective C–H functionalization. Surrogate redox…”
Get full text

Biochemical Characterization of NotB as an FAD-Dependent Oxidase in the Biosynthesis of Notoamide Indole Alkaloids by Li, Shengying, Finefield, Jennifer M, Sunderhaus, James D, McAfoos, Timothy J, Williams, Robert M, Sherman, David H

“…Notoamides produced by Aspergillus spp. bearing the bicyclo[2.2.2]diazaoctane core structure with unusual structural diversity represent a compelling system to…”
Get full text

Effects of timber infill walls on the seismic behavior of traditional Chinese timber frames by Xie, Qifang, Zhang, Baozhuang, Li, Shengying, Wu, Fanfan, Yang, Huifeng

“…This study investigates the enhanced effect of timber infill walls on the seismic behavior of traditional Chinese timber frames. Two 1/2 scaled traditional…”
Get full text

Substrate Conformational Switch Enables the Stereoselective Dimerization in P450 NascB: Insights from Molecular Dynamics Simulations and Quantum Mechanical/Molecular Mechanical Calculations by Zhou, Tai-Ping, Feng, Jianqiang, Wang, Yongchao, Li, Shengying, Wang, Binju

“…P450 NascB catalyzes the coupling of cyclo-(l-tryptophan-l-proline) (1) to generate (−)-naseseazine C (2) through intramolecular C–N bond formation and…”
Get full text

Improving the Secretory Expression of an -Galactosidase from Aspergillus niger in Pichia pastoris by Zheng, Xianliang, Fang, Bo, Han, Dongfei, Yang, Wenxia, Qi, Feifei, Chen, Hui, Li, Shengying

“…α-Galactosidases are broadly used in feed, food, chemical, pulp, and pharmaceutical industries. However, there lacks a satisfactory microbial cell factory that…”
Get full text

Efficient Preparation of Bafilomycin A1 from Marine Streptomyces lohii Fermentation Using Three-Phase Extraction and High-Speed Counter-Current Chromatography by Yuan, Ye, He, Xiaoping, Wang, Tingting, Zhang, Xingwang, Li, Zhong, Xu, Xiaoqing, Zhang, Weiyan, Yan, Xiaojun, Li, Shengying, He, Shan

“…An efficient strategy was developed for the rapid separation and enrichment of bafilomycin A1 (baf A1) from a crude extract of the marine microorganism…”
Get full text