Search Results - "Li, Shanhe"

Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress by Lin, Xiaotong, Zhao, Yan, Li, Shanhe

“…Astaxanthin (AST) is a carotenoid that has been shown to have neuroprotective effects. In this study, it was found that AST significantly inhibited…”
Get full text

Hydrogel in the Treatment of Traumatic Brain Injury by Li, Shanhe, Xu, Jiajun, Qian, Yuqing, Zhang, Ruiping

“…The high prevalence of traumatic brain injury (TBI) poses an important global public health challenge. Current treatment modalities for TBI primarily involve…”
Get full text

Integrated microfluidic single-cell immunoblotting chip enables high-throughput isolation, enrichment and direct protein analysis of circulating tumor cells by Abdulla, Aynur, Zhang, Ting, Li, Shanhe, Guo, Wenke, Warden, Antony R., Xin, Yufang, Maboyi, Nokuzola, Lou, Jiatao, Xie, Haiyang, Ding, Xianting

“…Effective capture and analysis of a single circulating tumor cell (CTC) is instrumental for early diagnosis and personalized therapy of tumors. However, due to…”
Get full text

Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer by Gou, Yi, Chen, MeiRong, Li, Shanhe, Deng, JunGang, Li, Jinlong, Fang, GuiHua, Yang, Feng, Huang, GuoJin

“…Anticancer agents that present nonapoptotic cell death pathways are required for treating apoptosis-resistant pancreatic cancer. Here, we synthesized three…”
Get full text

Ferroptosis-inducing nanocomposite hydrogels: A multimodal platform for enhanced cancer therapeutics by Li, Shanhe, Qian, Yuqing, Zhang, Xuan, Xu, Jiajun, Zhang, Ruiping

“…The core of this review is to combine ferroptosis with nanocomposite hydrogels for a more targeted approach in cancer treatment. The basic principle of…”
Get full text

Developing an Anticancer Platinum(II) Compound Based on the Uniqueness of Human Serum Albumin by Zhang, Zhenlei, Zhang, Juzheng, Yang, Tongfu, Li, Shanhe, Xu, Gang, Liang, Hong, Yang, Feng

“…To develop the next-generation Pt drug with remarkable activity and low toxicity to maximally inhibit tumor growth, we optimized a Pt­(II) thiosemicarbazone…”
Get full text

Developing a Multitargeted Anticancer Palladium(II) Agent Based on the His-242 Residue in the IIA Subdomain of Human Serum Albumin by Li, Wenjuan, Li, Shanhe, Zhang, Zhenlei, Xu, Gang, Man, Xueyu, Yang, Feng, Liang, Hong

“…To obtain next-generation metal drugs that can overcome the deficiencies of platinum (Pt) drugs and treat cancer more effectively, we proposed to develop a…”
Get full text

Developing a Ruthenium(III) Complex to Trigger Gasdermin E‑Mediated Pyroptosis and an Immune Response Based on Decitabine and Liposomes: Targeting Inhibition of Gastric Tumor Growth and Metastasis by Li, Wenjuan, Li, Shanhe, Xu, Gang, Man, Xueyu, Yang, Tongfu, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…To develop next-generation metal drugs with high efficiency and low toxicity for targeting inhibition of gastric tumor growth and metastasis, we not only…”
Get full text

Developing a Gadolinium(III) Compound Based on Apoferritin for Targeted Magnetic Resonance Imaging and Dual-Modal Therapy of Cancer by Man, Xueyu, Yang, Tongfu, Li, Wenjuan, Li, Shanhe, Xu, Gang, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…To integrate targeted diagnosis and treatment of cancer, we proposed to develop a gadolinium (Gd) agent based on the properties of apoferritin (AFt). To this…”
Get full text

Developing a Novel Gold(III) Agent to Treat Glioma Based on the Unique Properties of Apoferritin Nanoparticles: Inducing Lethal Autophagy and Apoptosis by Zhang, Juzheng, Zhang, Zhenlei, Jiang, Ming, Li, Shanhe, Yuan, Haoliang, Sun, Hongbin, Yang, Feng, Liang, Hong

“…Effective delivery of anticancer agents across the blood–brain barrier (BBB) required innovative strategies to achieve glioma regression. To resolve this…”
Get full text

Developing a Novel Indium(III) Agent Based on Human Serum Albumin Nanoparticles: Integrating Bioimaging and Therapy by Zhang, Zhenlei, Yang, Tongfu, Zhang, Juzheng, Li, Wenjuan, Li, Shanhe, Sun, Hongbin, Liang, Hong, Yang, Feng

“…To effectively integrate diagnosis and therapy for tumors, we proposed to develop an indium (In) agent based on the unique property of human serum albumin…”
Get full text

Designing a Mitochondria-Targeted Theranostic Cyclometalated Iridium(III) Complex: Overcoming Cisplatin Resistance and Inhibiting Tumor Metastasis through Necroptosis and Immune Response by Li, Wenjuan, Li, Ting, Pan, Ying, Li, Shanhe, Xu, Gang, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…To develop a potential theranostic metal agent to reverse the resistance of cancer cells to cisplatin and effectively inhibit tumor growth and metastasis, we…”
Get full text

Developing a Novel Anticancer Gold(III) Agent to Integrate Chemotherapy and Immunotherapy by Zhang, Juzheng, Jiang, Ming, Li, Shanhe, Zhang, Zhenlei, Sun, Hongbin, Yang, Feng, Liang, Hong

“…To effectively treat gastric cancer, we innovatively attempted to develop a metal agent to integrate immunotherapy and chemotherapy by dual targeting the…”
Get full text

Label-free Separation of Circulating Tumor Cells Using a Self-Amplified Inertial Focusing (SAIF) Microfluidic Chip by Abdulla, Aynur, Zhang, Ting, Ahmad, Khan Zara, Li, Shanhe, Lou, Jiatao, Ding, Xianting

“…Circulating tumor cells (CTCs) are rare cells existing in the bloodstream with a relatively low number, which facilitate as a predictor of cancer progress…”
Get full text

Developing a Copper(II) Isopropyl 2‑Pyridyl Ketone Thiosemicarbazone Compound Based on the IB Subdomain of Human Serum Albumin–Indomethacin Complex: Inhibiting Tumor Growth by Remodeling the Tumor Microenvironment by Man, Xueyu, Li, Shanhe, Xu, Gang, Li, Wenjuan, Zhu, Minghui, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…To develop a next-generation metal agent and dual-agent multitargeted combination therapy, we developed a copper (Cu) compound based on the properties of the…”
Get full text

Novel mono-, bi-, tri- and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis by Wang, Xiaojun, Zhu, Minghui, Li, Shanhe, Xu, Gang, Zhang, Zhenlei, Yang, Feng

“…To develop the next-generation metal agents for efficiently inhibiting tumor growth, a series of novel mononuclear, binuclear and trinuclear copper (Cu)…”
Get full text

Anticancer Tetranuclear Cu(I) Complex Catalyzes a Click Reaction to Synthesize a Chemotherapeutic Agent in situ to Achieve Targeted Dual-Agent Combination Therapy for Cancer by Man, Xueyu, Li, Wenjuan, Zhu, Minghui, Li, Shanhe, Xu, Gang, Zhang, Zhenlei, Yang, Feng, Liang, Hong

“…To develop next-generation metal-based drugs and dual-drug combination therapy for cancer, we proposed to develop a copper (Cu) complex that exerts anticancer…”
Get full text

Developing a Rhodium(III) Complex to Reprogram the Tumor Immune and Metabolic Microenvironments: Overcoming Multidrug Resistance and Metastasis in Non-Small Cell Lung Cancer by Li, Wenjuan, Li, Shanhe, Zhu, Minghui, Xu, Gang, Man, Xueyu, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…To effectively inhibit the growth and metastasis of non-small cell lung cancer (NSCLC) and overcome its multidrug resistance (MDR), we designed and synthesized…”
Get full text

Rational Design of a Hetero-multinuclear Gadolinium(III)-Copper(II) Complex: Integrating Magnetic Resonance Imaging, Photoacoustic Imaging, Mild Photothermal Therapy, Chemotherapy and Immunotherapy of Cancer by Man, Xueyu, Li, Wenjuan, Zhu, Minghui, Li, Shanhe, Xu, Gang, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…For more accurate diagnosis and effective treatment of cancer, we proposed to develop a hetero-multinuclear metal complex based on the property of apoferritin…”
Get full text

Developing a Hetero-Trinuclear Erbium(III)-Copper(II) Complex Based on Apoferritin: Targeted Photoacoustic Imaging and Multimodality Therapy of Tumor by Zhu, Minghui, Man, Xueyu, Tongfu, Yang, Li, Wenjuan, Li, Shanhe, Xu, Gang, Zhang, Zhenlei, Liang, Hong, Yang, Feng

“…For the integration of targeted diagnosis and treatment of tumor, we innovatively designed and synthesized a single-molecule hetero-multinuclear Er(III)-Cu(II)…”
Get full text