Search Results - "Li, Rick Z."
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
Published in Immunity (Cambridge, Mass.) (16-06-2020)“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Heterogeneity of HSCs in a Mouse Model of NASH
Published in Hepatology (Baltimore, Md.) (01-08-2021)“…Background and Aims In clinical and experimental NASH, the origin of the scar‐forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to…”
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TIANA: transcription factors cooperativity inference analysis with neural attention
Published in BMC bioinformatics (22-08-2024)“…Growing evidence suggests that distal regulatory elements are essential for cellular function and states. The sequences within these distal elements,…”
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4
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Published in Immunity (Cambridge, Mass.) (09-08-2022)“…Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of…”
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Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs
Published in eLife (20-01-2022)“…Regulation of gene expression requires the combinatorial binding of sequence-specific transcription factors (TFs) at promoters and enhancers. Prior studies…”
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Human microglia maturation is underpinned by specific gene regulatory networks
Published in Immunity (Cambridge, Mass.) (12-09-2023)“…Microglia phenotypes are highly regulated by the brain environment, but the transcriptional networks that specify the maturation of human microglia are poorly…”
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Heterogeneity of hepatic stellate cells in a mouse model of non-alcoholic steatohepatitis (NASH)
Published in Hepatology (Baltimore, Md.) (01-08-2021)“…In clinical and experimental non-alcoholic steatohepatitis (NASH), the origin of the scar-forming myofibroblast is the hepatic stellate cell (HSC). We used…”
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Journal Article -
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Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
Published in Immunity (Cambridge, Mass.) (01-05-2020)“…Tissue resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
Get full text
Journal Article