Search Results - "Li, Qiji"
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1
MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer
Published in Theranostics (01-01-2021)“…Resistance to androgen-deprivation therapy (ADT) associated with metastatic progression remains a challenging clinical task in prostate cancer (PCa) treatment…”
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2
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer
Published in EMBO molecular medicine (01-12-2019)“…Resistance to tamoxifen is a clinically major challenge in breast cancer treatment. Although downregulation of estrogen receptor‐alpha (ERα) is the dominant…”
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3
Investigation of the Pharmacodynamic Components of Gastrodia elata Blume for Treatment of Type 2 Diabetes Mellitus through HPLC, Bioactivity, Network Pharmacology and Molecular Docking
Published in International journal of molecular sciences (01-10-2024)“…The occurrence of type 2 diabetes mellitus (T2DM), a worldwide chronic disease, is mainly caused by insufficient insulin production and places a huge burden on…”
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4
Neuroprotection of Kaji-Ichigoside F1 via the BDNF/Akt/mTOR Signaling Pathways against NMDA-Induced Neurotoxicity
Published in International journal of molecular sciences (18-12-2022)“…Kaji-ichigoside F1 (KF1), a natural oleanane-type triterpenoid saponin, is the main active constituent from . In the southwest regions of China, particularly…”
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5
Dynamic changes of differential metabolites and key metabolic pathways of Gastrodia elata Blume during fermentation
Published in International journal of food properties (31-12-2022)“…The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the…”
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6
PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway
Published in Journal of experimental & clinical cancer research (23-06-2017)“…PHF21B is newly identified to be involved in the tumor progression; however, its biological role and molecular mechanism in prostate cancer have not been…”
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Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling
Published in Journal of bone and mineral metabolism (2022)“…Introduction Heterotopic ossification of tendons and ligaments is a painful and debilitating disease with no effective treatment. Although aging has been…”
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8
Acidic extracellular pH promotes prostate cancer bone metastasis by enhancing PC-3 stem cell characteristics, cell invasiveness and VEGF-induced vasculogenesis of BM-EPCs
Published in Oncology reports (01-10-2016)“…Bone metastasis is a main cause of cancer-related mortality in patients with advanced prostate cancer. Emerging evidence suggests that the acidic extracellular…”
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9
Deletion of Wild-type p53 Facilitates Bone Metastatic Function by Blocking the AIP4 Mediated Ligand-Induced Degradation of CXCR4
Published in Frontiers in pharmacology (01-02-2022)“…Management of patients with prostate cancer and bone metastatic disease remains a major clinical challenge. Loss or mutation of p53 has been identified to be…”
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Erratum To: Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer
Published in EMBO molecular medicine (07-03-2022)Get full text
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11
Fermented Gastrodia elata Bl. Alleviates Cognitive Deficits by Regulating Neurotransmitters and Gut Microbiota in D-Gal/AlCl3-Induced Alzheimer’s Disease-like Mice
Published in Foods (08-07-2024)“…Alzheimer’s disease (AD) is a common neurological disease with recognition ability loss symptoms and a major contributor to dementia cases worldwide. Gastrodia…”
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12
N-cadherin promotes epithelial-mesenchymal transition and cancer stem cell-like traits via ErbB signaling in prostate cancer cells
Published in International journal of oncology (01-02-2016)“…N-cadherin has been reported to be upregulated and associated with metastasis and poor prognosis in prostate cancer patients, however the underlying mechanism…”
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13
Optimization of Extraction Process and Simultaneous Content Determination for Quality Marker from Rosa roxburghii
Published in Shipin gongye ke-ji (01-07-2022)“…Extraction process for Q-markers from Rosa roxburghii using response surface methodology was optimized and HPLC method was established for simultaneous…”
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14
Dabco-catalysed selective chlorination of aromatics
Published in Tetrahedron letters (17-02-2024)“…A Lewis base catalyst DABCO for highly efficient electrophilic aromatic chlorination using NCS was presented. The mild conditions, easy-availability and…”
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15
Anti-depressant-like effect of fermented Gastrodia elata Bl. by regulating monoamine levels and BDNF/NMDAR pathways in mice
Published in Journal of ethnopharmacology (30-01-2023)“…Gastrodia elata Blume (GE) is a Chinese medicinal herb commonly used to treat central nervous system-related diseases, including headaches, dizziness,…”
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16
Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis Acylphloroglucinol Meroterpenoids from Hypericum bellum Flowers
Published in Journal of agricultural and food chemistry (20-01-2021)“…In this work, 26 methylated acylphloroglucinol meroterpenoids with diverse skeletons, including 18 new ones (bellumones A-R, 1–18), were identified from the…”
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17
FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling
Published in Cancer letters (28-08-2017)“…Abstract Prostate cancer (PCa) is the second most frequently diagnosed cancer among men and exhibits a high propensity to metastasize to bone. Currently, bone…”
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18
Synthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells
Published in Bioorganic & medicinal chemistry (01-04-2022)“…[Display omitted] •Synthesis of 28 novel 1-phenyl-benzopyrrolizidin-3-one derivatives.•Compound 11 m has shown good neuroprotective effect on NMDA-induced…”
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Inhibitory effect of Incarvillea diffusa Royle extract in the formation of calcium oxalate nephrolithiasis by regulating ROS-induced Nrf2/HO-1 pathway in rats
Published in Journal of ethnopharmacology (10-05-2024)“…Calcium oxalate (CaOx) kidney stones are widely acknowledged as the most prevalent type of urinary stones, with high incidence and recurrence rates…”
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Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo
Published in Phytomedicine (Stuttgart) (20-07-2022)“…Spiropachysine A is the extracted compound of traditional Chinese ethnic medicine Pachysandra axillaries Franch. var. styiosa (Dunn) M. Cheng. Spiropachysine A…”
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