Search Results - "Li, Peter Yiqing"
-
1
A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse Heart
Published in Circulation research (30-09-2016)“…RATIONALE:Cardiovascular disease represents a global pandemic. The advent of and recent advances in mouse genomics, epigenomics, and transgenics offer…”
Get full text
Journal Article -
2
Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy
Published in Cardiovascular research (01-12-2019)“…Abstract Aims We and others have previously described the expression landscape of circular RNA (circRNA) in mouse and human hearts. However, the functional…”
Get full text
Journal Article -
3
Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy
Published in Molecular therapy (03-06-2020)“…Circular RNAs (circRNAs) sequester microRNAs (miRNAs) and repress their endogenous activity. We hypothesized that artificial circRNA sponges (circmiRs) can be…”
Get full text
Journal Article -
4
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy
Published in Nature communications (05-08-2021)“…Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with a cardiomyocyte-specific Lmna deletion develop…”
Get full text
Journal Article -
5
Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress–Gene Response
Published in Circulation (New York, N.Y.) (16-04-2019)“…BACKGROUND:The human genome folds in 3 dimensions to form thousands of chromatin loops inside the nucleus, encasing genes and cis-regulatory elements for…”
Get full text
Journal Article -
6
8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction
Published in Oxidative medicine and cellular longevity (2022)“…Doxorubicin is an anthracycline widely used for the treatment of various cancers; however, the drug has a common deleterious side effect, namely a…”
Get full text
Journal Article -
7
FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy
Published in International journal of cardiology (15-09-2015)“…Abstract Background Congestive heart failure (CHF) is a significant health care burden in developed countries. However, the molecular events leading from…”
Get full text
Journal Article -
8
Dimethyl sulfoxide (DMSO) enhances direct cardiac reprogramming by inhibiting the bromodomain of coactivators CBP/p300
Published in Journal of molecular and cellular cardiology (01-11-2021)“…Direct cardiac reprogramming represents an attractive way to reversing heart damage caused by myocardial infarction because it removes fibroblasts, while also…”
Get full text
Journal Article -
9
Genetic Admixture in the Culturally Unique Peranakan Chinese Population in Southeast Asia
Published in Molecular biology and evolution (01-10-2021)“…Abstract The Peranakan Chinese are culturally unique descendants of immigrants from China who settled in the Malay Archipelago ∼300–500 years ago. Today, among…”
Get full text
Journal Article