Search Results - "Li, P. Jonathan"

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency by Nguyen, David N., Roth, Theodore L., Li, P. Jonathan, Chen, Peixin Amy, Apathy, Ryan, Mamedov, Murad R., Vo, Linda T., Tobin, Victoria R., Goodman, Daniel, Shifrut, Eric, Bluestone, Jeffrey A., Puck, Jennifer M., Szoka, Francis C., Marson, Alexander

“…Versatile and precise genome modifications are needed to create a wider range of adoptive cellular therapies 1 – 5 . Here we report two improvements that…”
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Recent Advances in Liver Transplantation for Hepatocellular Carcinoma by Li, P. Jonathan, Shah, Sachin, Mehta, Neil

“…Opinion Statement Liver transplantation for hepatocellular carcinoma (HCC) remains an evolving field. Major challenges HCC transplant patients face today…”
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Endothelial cells express NKG2D ligands and desensitize antitumor NK responses by Thompson, Thornton W, Kim, Alexander Byungsuk, Li, P Jonathan, Wang, Jiaxi, Jackson, Benjamin T, Huang, Kristen Ting Hui, Zhang, Lily, Raulet, David H

“…Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules and pro-inflammatory cytokines upon recognition of…”
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Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages by Thompson, Thornton W, Jackson, Benjamin T, Li, P Jonathan, Wang, Jiaxi, Kim, Alexander Byungsuk, Huang, Kristen Ting Hui, Zhang, Lily, Raulet, David H

“…NKG2D is an important immunoreceptor expressed on the surface of NK cells and some T cells. NKG2D recognizes a set of ligands typically expressed on infected…”
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Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models by Li, P Jonathan, Roose, Jeroen P, Jablons, David M, Kratz, Johannes R

“…3D models of cancer have the potential to improve basic, translational, and clinical studies. Patient-derived xenografts, spheroids, and organoids are broad…”
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287 Genomic and Immunologic Characterization of Lung Adenocarcinoma in Never Smokers vs. Smokers by Li, P. Jonathan, Tsui, Jessica, Ding, Vivianne W., Combes, Alexis J., Krummel, Matthew F., Jablons, David M., Kratz, Johannes R.

“…OBJECTIVES/GOALS: Smoking is a well-established risk factor for lung cancer, but never smokers account for up to 25% of lung cancer cases. There is mounting…”
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Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function by Shifrut, Eric, Carnevale, Julia, Tobin, Victoria, Roth, Theodore L., Woo, Jonathan M., Bui, Christina T., Li, P. Jonathan, Diolaiti, Morgan E., Ashworth, Alan, Marson, Alexander

“…Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug…”
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AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation by Norman, Joshua S., Li, P. Jonathan, Kotwani, Prashant, Shui, Amy M., Yao, Francis, Mehta, Neil

“…Alpha-fetoprotein (AFP) predicts hepatocellular carcinoma (HCC) recurrence after liver transplant (LT) but remains an imperfect biomarker. The role of DCP…”
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Reprogramming human T cell function and specificity with non-viral genome targeting by Roth, Theodore L., Puig-Saus, Cristina, Yu, Ruby, Shifrut, Eric, Carnevale, Julia, Li, P. Jonathan, Hiatt, Joseph, Saco, Justin, Krystofinski, Paige, Li, Han, Tobin, Victoria, Nguyen, David N., Lee, Michael R., Putnam, Amy L., Ferris, Andrea L., Chen, Jeff W., Schickel, Jean-Nicolas, Pellerin, Laurence, Carmody, David, Alkorta-Aranburu, Gorka, del Gaudio, Daniela, Matsumoto, Hiroyuki, Morell, Montse, Mao, Ying, Cho, Min, Quadros, Rolen M., Gurumurthy, Channabasavaiah B., Smith, Baz, Haugwitz, Michael, Hughes, Stephen H., Weissman, Jonathan S., Schumann, Kathrin, Esensten, Jonathan H., May, Andrew P., Ashworth, Alan, Kupfer, Gary M., Greeley, Siri Atma W., Bacchetta, Rosa, Meffre, Eric, Roncarolo, Maria Grazia, Romberg, Neil, Herold, Kevan C., Ribas, Antoni, Leonetti, Manuel D., Marson, Alexander

“…Decades of work have aimed to genetically reprogram T cells for therapeutic purposes 1 , 2 using recombinant viral vectors, which do not target transgenes to…”
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Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies by Roth, Theodore L., Li, P. Jonathan, Blaeschke, Franziska, Nies, Jasper F., Apathy, Ryan, Mowery, Cody, Yu, Ruby, Nguyen, Michelle L.T., Lee, Youjin, Truong, Anna, Hiatt, Joseph, Wu, David, Nguyen, David N., Goodman, Daniel, Bluestone, Jeffrey A., Ye, Chun Jimmie, Roybal, Kole, Shifrut, Eric, Marson, Alexander

“…Adoptive transfer of genetically modified immune cells holds great promise for cancer immunotherapy. CRISPR knockin targeting can improve cell therapies, but…”
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AFP-L3 and DCP are superior to AFP in predicting waitlist dropout in HCC patients: Results of a prospective study by Mehta, Neil, Kotwani, Prashant, Norman, Joshua, Shui, Amy, Li, P Jonathan, Saxena, Varun, Chan, Wesley, Yao, Francis Y

“…In patients with HCC awaiting liver transplantation (LT), there is a need to identify biomarkers that are superior to AFP in predicting prognosis. AFP-L3 and…”
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Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma by Balcerek, Joanna, Trejo, Evelin, Levine, Kendall, Couey, Paul, Kornberg, Zoe V, Rogine, Camille, Young, Charlotte, Li, P Jonathan, Shy, Brian R, Taylor, Jordan E, Bakhtary, Sara, Friedlander, Terence, Lynch, Kara L, Bern, Caryn, Esensten, Jonathan H

“…Abstract Objectives Serologic testing for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in potential donors of coronavirus disease…”
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Pooled Knock-In Targeting for Genome Engineering of Cellular Immunotherapies by Roth, Theodore L., Li, P. Jonathan, Blaeschke, Franziska, Nies, Jasper F., Apathy, Ryan, Mowery, Cody, Yu, Ruby, Nguyen, Michelle L.T., Lee, Youjin, Truong, Anna, Hiatt, Joseph, Wu, David, Nguyen, David N., Goodman, Daniel, Bluestone, Jeffrey A., Ye, Chun Jimmie, Roybal, Kole, Shifrut, Eric, Marson, Alexander

“…Adoptive transfer of genetically-modified immune cells holds great promise for cancer immunotherapy. CRISPR knock-in targeting can improve cell therapies, but…”
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