Search Results - "Li, Lauri"

Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS by Flanagan, Ken, Fitzgerald, Kent, Baker, Jeanne, Regnstrom, Karin, Gardai, Shyra, Bard, Frederique, Mocci, Simonetta, Seto, Pui, You, Monica, Larochelle, Catherine, Prat, Alexandre, Chow, Samuel, Li, Lauri, Vandevert, Chris, Zago, Wagner, Lorenzana, Carlos, Nishioka, Christopher, Hoffman, Jennifer, Botelho, Raquel, Willits, Christopher, Tanaka, Kevin, Johnston, Jennifer, Yednock, Ted

“…TH17 cells enter tissues to facilitate pathogenic autoimmune responses, including multiple sclerosis (MS). However, the adhesion molecules involved in the…”
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Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer by Lum, Amy M, Wang, Bruce B, Beck-Engeser, Gabriele B, Li, Lauri, Channa, Namitha, Wabl, Matthias

“…GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of…”
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Activation of an Oncogenic MicroRNA Cistron by Provirus Integration by Wang, Clifford L., Wang, Bruce B., Bartha, Gábor, Li, Lauri, Channa, Namitha, Klinger, Mark, Killeen, Nigel, Wabl, Matthias

“…Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine…”
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Retroviral activation of the mir-106a microRNA cistron in T lymphoma by Lum, Amy M, Wang, Bruce B, Li, Lauri, Channa, Namitha, Bartha, Gabor, Wabl, Matthias

“…Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic…”
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PRX012 induces microglia‐mediated clearance of pyroglutamate‐modified Aβ in Alzheimer’s Disease brain tissue by Tam, Stephen, Zhang, Gang, Li, Lauri, Elmaarouf, Abderrahman, Skov, Michael, Dolan, Philip, Kinney, Gene G, Campbell, Brian, Zago, Wagner M

“…Background Alzheimer’s disease (AD) is a devastating neurodegenerative disorder featuring hallmark Aβ plaques that spread throughout the brain as the disease…”
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Aggregated Light Chain Increases Brain Natriuretic Peptide Expression and Induces Oxidative Stress Response in Cardiomyocytes by Tam, Stephen J., Li, Lauri, Renz, Mark, Dolan, Philip J., Nijjar, Tarlochan, Goldbach, Erich, Kinney, Gene G., Zago, Wagner

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017 - Aggregated Light Chain Increases Brain Natriuretic Peptide Expression and Induces Oxidative Stress Response in Cardiomyocytes by Tam, Stephen J., Li, Lauri, Renz, Mark, Dolan, Philip J., Nijjar, Tarlochan, Goldbach, Erich, Kinney, Gene G., Zago, Wagner

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2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis by Renz, Mark, Torres, Ronald, Dolan, Philip J., Tam, Stephen J., Tapia, Jose R., Li, Lauri, Salmans, Joshua R., Barbour, Robin M., Shughrue, Paul J., Nijjar, Tarlochan, Schenk, Dale, Kinney, Gene G., Zago, Wagner

“…Amyloid light chain (AL) amyloidosis is characterized by misfolded light chain (LC) (amyloid) deposition in various peripheral organs, leading to progressive…”
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Abstract 1681: Inhibition of tumor growth in vivo through neutralization of the interaction of MCAM with laminin alpha 4 by Flanagan, Ken, Li, Lauri W., Lorenzana, Carlos, Tam, Stephen J., Liu, Yue, Dolan, Philip J., Alexander, Lana, Salmans, Josh, Barbour, Robin M., Higaki, Jeffrey N., Nijjar, Tarlochan, Zago, Wagner, Yednock, Ted A., Kinney, Gene

“…Abstract Melanoma cell adhesion molecule (MCAM/CD146) is highly expressed on a subset of many tumor types including melanoma and glioblastoma, and expression…”
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Abstract 355: A monoclonal antibody against laminin alpha 4 inhibits both MCAM and integrin-a6b1 binding, blocks tumor cell adhesion in vitro and slows melanoma tumor growth in vivo by Tam, Stephen J., Li, Lauri E., Lorenzana, Carlos, Liu, Yue, Flanagan, Ken, Dolan, Philip J., Alexander, Lana, Salmans, Josh, Barbour, Robin M., Higaki, Jeffrey N., Nijjar, Tarlochan, Zago, Wagner, Yednock, Ted A., Kinney, Gene

“…Abstract Laminin is an extracellular matrix molecule that is secreted as a trimeric protein composed of an α, β and γ chain. There are five distinct laminin α…”
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Anti-Mcam Monoclonal Antibody PRX003 Inhibits the Unique Migratory Potential of Pathogenic IL-17–Producing T Cells by Flanagan, Kenneth, Tam, Stephen J, Li, Lauri, Dolan, Philip J, Barbour, Robin M, Higaki, Jeffrey N, Liu, Yue, Nijjar, Tarlochan, Skov, Michael, Zago, Wagner, Yednock, Ted A, Kinney, Gene F, Ness, Dan

“…Rationale Melanoma cell adhesion molecule (MCAM) expression on a small subset of memory CD4+/CD8+ T cells defines their ability to secrete IL-17 and identifies…”
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Retroviral activation of the mir-106a microRNA cistron in T lymphoma by Lum, Amy M, Wang, Bruce B, Li, Lauri, Channa, Namitha, Bartha, Gabor, Wabl, Matthias

“…Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic…”
Get full text