Search Results - "Li, King Lun"

Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex by Schlecht, William, Li, King-Lun, Hu, Dehong, Dong, Wenji

“…Calcium sensitizers enhance the transduction of the Ca2+ signal into force within the heart and have found use in treating heart failure. However the…”
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Direct interaction between troponin and myosin enhances the ATPase activity of heavy meromyosin by Ghashghaee, Nazanin Bohlooli, Li, King-Lun, Dong, Wen-Ji

“…Contractility of the heart muscle is a result of sliding movements between thick and thin filaments, produced by interactions between actin and myosin during…”
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Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving by He, Yi, Wang, Junshi, Li, King-Lun, Wang, Yao Q, Freyberg, Zachary, Dong, Yan

“…After drug withdrawal, a key factor triggering relapse is progressively intensified cue-associated drug craving, termed incubation of drug craving. After…”
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Nucleus accumbens feedforward inhibition circuit promotes cocaine self-administration by Yu, Jun, Yan, Yijin, Li, King-Lun, Wang, Yao, Huang, Yanhua H., Urban, Nathaniel N., Nestler, Eric J., Schlüter, Oliver M., Dong, Yan

“…The basolateral amygdala (BLA) sends excitatory projections to the nucleus accumbens (NAc) and regulates motivated behaviors partially by activating NAc medium…”
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Cocaine Triggers Astrocyte-Mediated Synaptogenesis by Wang, Junshi, Li, King-Lun, Shukla, Avani, Beroun, Ania, Ishikawa, Masago, Huang, Xiaojie, Wang, Yao, Wang, Yao Q., Yang, Yue, Bastola, Noah D., Huang, Hugh H., Kramer, Lily E., Chao, Terry, Huang, Yanhua H., Sesack, Susan R., Nestler, Eric J., Schlüter, Oliver M., Dong, Yan

“…Synaptogenesis is essential in forming new neurocircuits during development, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and…”
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Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking by Schall, Terra A., Li, King-Lun, Qi, Xiguang, Lee, Brian T., Wright, William J., Alpaugh, Erin E., Zhao, Rachel J., Liu, Jianwei, Li, Qize, Zeng, Bo, Wang, Lirong, Huang, Yanhua H., Schlüter, Oliver M., Nestler, Eric J., Nieh, Edward H., Dong, Yan

“…The nucleus accumbens (NAc) regulates reward-motivated behavior, but the temporal dynamics of NAc neurons that enable “free-willed” animals to obtain rewards…”
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In Situ Time-Resolved FRET Reveals Effects of Sarcomere Length on Cardiac Thin-Filament Activation by Li, King-Lun, Rieck, Daniel, Solaro, R. John, Dong, Wenji

“…During cardiac thin-filament activation, the N-domain of cardiac troponin C (N-cTnC) binds to Ca2+ and interacts with the actomyosin inhibitory troponin I…”
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Sarcomere length dependent effects on the interaction between cTnC and cTnI in skinned papillary muscle strips by Li, King-Lun, Ghashghaee, Nazanin Bohlooli, Solaro, R. John, Dong, Wenji

“…Sarcomere length dependent activation (LDA) of myocardial force development is the cellular basis underlying the Frank-Starling law of the heart, but it is…”
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Role of the C-terminus mobile domain of cardiac troponin I in the regulation of thin filament activation in skinned papillary muscle strips by Bohlooli Ghashghaee, Nazanin, Li, King-Lun, Solaro, R. John, Dong, Wen-Ji

“…The C-terminus mobile domain of cTnI (cTnI-MD) is a highly conserved region which stabilizes the actin-cTnI interaction during the diastole. Upon Ca2+-binding…”
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Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin by Li, King-Lun, Methawasin, Mei, Tanner, Bertrand C.W., Granzier, Henk L., Solaro, R. John, Dong, Wen-Ji

“…Cardiac performance is tightly regulated at the cardiomyocyte level by sarcomere length, such that increases in sarcomere length lead to sharply enhanced force…”
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Structural Dynamics of C-domain of Cardiac Troponin I Protein in Reconstituted Thin Filament by Zhou, Zhiqun, Li, King-Lun, Rieck, Daniel, Ouyang, Yexin, Chandra, Murali, Dong, Wen-Ji

“…The regulatory function of cardiac troponin I (cTnI) involves three important contiguous regions within its C-domain: the inhibitory region (IR), the…”
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FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation by Schlecht, William, Zhou, Zhiqun, Li, King-Lun, Rieck, Daniel, Ouyang, Yexin, Dong, Wen-Ji

“…•cTnT phosphorylation by PKC was mimicked in in vitro thin filaments.•I–C switching was monitored by FRET for these phospho-mimics.•Phospho-mimics altered I–C…”
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Structural basis for the in situ Ca2+ sensitization of cardiac troponin C by positive feedback from force-generating myosin cross-bridges by Rieck, Daniel C., Li, King-Lun, Ouyang, Yexin, Solaro, R. John, Dong, Wen-Ji

“…[Display omitted] •FRET was used to monitor Ca2+-dependent N-cTnC opening in skinned myocardial fibers.•Inhibition of strong cross-bridges reduced the maximal…”
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Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin I by Zhou, Zhiqun, Rieck, Daniel, Li, King-Lun, Ouyang, Yexin, Dong, Wen-Ji

“…[Display omitted] ► FRET study of effects of HCM-related cTnI mutations in reconstituted thin filaments. ► R146G/Q and R163W each uniquely impact interactions…”
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Sarcomere Length Dependent Effects on Ca2+-Induced Troponin Regulation within Chemically Skinned Cardiac Muscle Fibers by Li, King-Lun, Solaro, R. John, Dong, Wenji

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Direct Troponin-Myosin Interaction Enhances ATPase Activity of Cardiac HMM by Bohlooli Ghashghaee, Nazanin, Li, King-Lun, Dong, Wen-Ji

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Sarcomere Lengthdependent Effects on the Ca2+-Troponin Regulation in Skinned Myocardial Fiber from Titin RBM20 Deletion Mice by Li, King-Lun, Methawasin, Mei, Granzier, Henk, John Solaro, Ross, Tanner, Bertrand, Dong, Wen-Ji

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Sarcomere Lengthdependent Effects on the Ca 2+ -Troponin Regulation in Skinned Myocardial Fiber from Titin RBM20 Deletion Mice by Li, King-Lun, Methawasin, Mei, Granzier, Henk, John Solaro, Ross, Tanner, Bertrand, Dong, Wen-Ji

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Sarcomere length–dependent effects on Ca^sup 2+^-troponin regulation in myocardium expressing compliant titin by Li, King-Lun, Methawasin, Mei, Tanner, Bertrand CW, Granzier, Henk L, Solaro, R John, Dong, Wen-Ji

“…Cardiac performance is tightly regulated at the cardiomyocyte level by sarcomere length, such that increases in sarcomere length lead to sharply enhanced force…”
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Kinetic and Structural Characterization of Calcium Sensitizer Action on Thin Filament Function using FRET by Schlecht, William D., Dong, Wenji, Li, King Lun

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