Search Results - "Li, Jin Billy"

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers by Han, Leng, Diao, Lixia, Yu, Shuangxing, Xu, Xiaoyan, Li, Jie, Zhang, Rui, Yang, Yang, Werner, Henrica M.J., Eterovic, A. Karina, Yuan, Yuan, Li, Jun, Nair, Nikitha, Minelli, Rosalba, Tsang, Yiu Huen, Cheung, Lydia W.T., Jeong, Kang Jin, Roszik, Jason, Ju, Zhenlin, Woodman, Scott E., Lu, Yiling, Scott, Kenneth L., Li, Jin Billy, Mills, Gordon B., Liang, Han

“…Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not…”
Get full text

Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila by Ren, Xingjie, Yang, Zhihao, Xu, Jiang, Sun, Jin, Mao, Decai, Hu, Yanhui, Yang, Su-Juan, Qiao, Huan-Huan, Wang, Xia, Hu, Qun, Deng, Patricia, Liu, Lu-Ping, Ji, Jun-Yuan, Li, Jin Billy, Ni, Jian-Quan

“…The CRISPR/Cas9 system has recently emerged as a powerful tool for functional genomic studies in Drosophila melanogaster. However, single-guide RNA (sgRNA)…”
Get full text

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila by Deng, Patricia, Khan, Anzer, Jacobson, Dionna, Sambrani, Nagraj, McGurk, Leeanne, Li, Xianghua, Jayasree, Aswathy, Hejatko, Jan, Shohat-Ophir, Galit, O’Connell, Mary A., Li, Jin Billy, Keegan, Liam P.

“…ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent…”
Get full text

Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis by Liu, Xin, Sun, Tao, Shcherbina, Anna, Li, Qin, Jarmoskaite, Inga, Kappel, Kalli, Ramaswami, Gokul, Das, Rhiju, Kundaje, Anshul, Li, Jin Billy

“…Adenosine-to-inosine (A-to-I) RNA editing catalyzed by ADAR enzymes occurs in double-stranded RNAs. Despite a compelling need towards predictive understanding…”
Get full text

RADAR: a rigorously annotated database of A-to-I RNA editing by Ramaswami, Gokul, Li, Jin Billy

“…We present RADAR--a rigorously annotated database of A-to-I RNA editing (available at http://RNAedit.com). The identification of A-to-I RNA editing sites has…”
Get full text

Reliable Identification of Genomic Variants from RNA-Seq Data by Piskol, Robert, Ramaswami, Gokul, Li, Jin Billy

“…Identifying genomic variation is a crucial step for unraveling the relationship between genotype and phenotype and can yield important insights into human…”
Get full text

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing by Li, Jin Billy, Levanon, Erez Y., Yoon, Jung-Ki, Aach, John, Xie, Bin, LeProust, Emily, Zhang, Kun, Gao, Yuan, Church, George M.

“…Adenosine-to-inosine (A-to-I) RNA editing leads to transcriptome diversity and is important for normal brain function. To date, only a handful of functional…”
Get full text

Cis Regulatory Effects on A-to-I RNA Editing in Related Drosophila Species by Sapiro, Anne L., Deng, Patricia, Zhang, Rui, Li, Jin Billy

“…Adenosine-to-inosine RNA editing modifies maturing mRNAs through the binding of adenosine deaminase acting on RNA (Adar) proteins to double-stranded RNA…”
Get full text

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs by Walkley, Carl R, Li, Jin Billy

“…One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR…”
Get full text

Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity by Jarmoskaite, Inga, Li, Jin Billy

“…Innate immunity must be tightly regulated to enable sensitive pathogen detection while averting autoimmunity triggered by pathogen-like host molecules. A…”
Get full text

Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides by Merkle, Tobias, Merz, Sarah, Reautschnig, Philipp, Blaha, Andreas, Li, Qin, Vogel, Paul, Wettengel, Jacqueline, Li, Jin Billy, Stafforst, Thorsten

“…Site-directed RNA editing might provide a safer or more effective alternative to genome editing in certain clinical scenarios. Until now, RNA editing has…”
Get full text

Identification of human RNA editing sites: A historical perspective by Ramaswami, Gokul, Li, Jin Billy

“…•Historical review of methods to identify A-to-I RNA editing sites.•Our ability to identify editing sites is heavily dependent on the DNA sequencing…”
Get full text

Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs by Vogel, Paul, Moschref, Matin, Li, Qin, Merkle, Tobias, Selvasaravanan, Karthika D., Li, Jin Billy, Stafforst, Thorsten

“…Molecular tools that target RNA at specific sites allow recoding of RNA information and processing. SNAP-tagged deaminases guided by a chemically stabilized…”
Get full text

Deciphering the functions and regulation of brain-enriched A-to-I RNA editing by Li, Jin Billy, Church, George M

“…Brain enriched RNA editing of Adenosine-to-Inosine (A-to-I) increases the amount of information encoded in the genome and diversifies the transcriptome. Here…”
Get full text

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself by Liddicoat, Brian J., Piskol, Robert, Chalk, Alistair M., Ramaswami, Gokul, Higuchi, Miyoko, Hartner, Jochen C., Li, Jin Billy, Seeburg, Peter H., Walkley, Carl R.

“…Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA)…”
Get full text

Accurate identification of human Alu and non-Alu RNA editing sites by Ramaswami, Gokul, Lin, Wei, Piskol, Robert, Tan, Meng How, Davis, Carrie, Li, Jin Billy

“…A computational framework is reported for the accurate and sensitive identification of RNA editing sites from whole-genome DNA and RNA sequences from the same…”
Get full text

Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses by George, Cyril X., Ramaswami, Gokul, Li, Jin Billy, Samuel, Charles E.

“…Adenosine deaminases acting on double-stranded RNA (ADARs) catalyze the deamination of adenosine (A) to produce inosine (I) in double-stranded (ds) RNA…”
Get full text

The evolution and adaptation of A-to-I RNA editing by Yablonovitch, Arielle L, Deng, Patricia, Jacobson, Dionna, Li, Jin Billy

“…Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein…”
Get full text

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes by Bazak, Lily, Haviv, Ami, Barak, Michal, Jacob-Hirsch, Jasmine, Deng, Patricia, Zhang, Rui, Isaacs, Farren J, Rechavi, Gideon, Li, Jin Billy, Eisenberg, Eli, Levanon, Erez Y

“…RNA molecules transmit the information encoded in the genome and generally reflect its content. Adenosine-to-inosine (A-to-I) RNA editing by ADAR proteins…”
Get full text

Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing by Zhang, Rui, Deng, Patricia, Jacobson, Dionna, Li, Jin Billy

“…Adenosine-to-inosine RNA editing diversifies the transcriptome and promotes functional diversity, particularly in the brain. A plethora of editing sites has…”
Get full text